Department of Pharmacy

Department of Pharmacy Research Pharmacokinetics and Pharmacodynamics Translational pharmacokinetics / ... Publications

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Recent publications

Brain barriers virtual: an interim solution or future opportunity?

Holder, Brianna M.; Tolan, Shaina E.; Heinrich, Kaleb K.; Miller, Kaitlin C. et al.

Part of Fluids and Barriers of the CNS, 2022.

DOI for Brain barriers virtual: an interim solution or future opportunity? Download full text (pdf) of Brain barriers virtual: an interim solution or future opportunity?

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Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure

Backstrom, E.; Erngren, T.; Fihn, B-M; Sadiq, M. W. et al.

Part of Journal of Pharmaceutical Sciences, p. 852-858, 2022.

DOI for Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure
Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Part of Pharmaceutical research, p. 1283-1289, 2022.

DOI for Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics
Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Part of Pharmaceutical research, p. 1291-1296, 2022.

DOI for Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor
Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Part of Pharmaceutical research, p. 1321-1341, 2022.

DOI for Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development Download full text (pdf) of Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

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Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

de Lange, Elizabeth C. M.; Hammarlund-Udenaes, Margareta

Part of Clinical Pharmacology and Therapeutics, p. 758-773, 2022.

DOI for Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics Download full text (pdf) of Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

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Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya et al.

Part of IEEE journal of biomedical and health informatics, p. 371-380, 2021.

DOI for Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images Download full text (pdf) of Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

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Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Sadiq, Muhammad Waqas; Holz, Olaf; Ellinghusen, Birthe D.; Faulenbach, Cornelia et al.

Part of British Journal of Pharmacology, p. 4440-4451, 2021.

DOI for Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Open access
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Part of Molecular Psychiatry, p. 7732-7745, 2021.

DOI for Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier. Download full text (pdf) of Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Open access
Brain Distribution of Drugs:: Pharmacokinetic Considerations

Loryan, Irena; Hammarlund-Udenaes, Margareta; Syvänen, Stina

Part of Handbook of Experimental Pharmacology, 2020.

DOI for Brain Distribution of Drugs:: Pharmacokinetic Considerations
In Vivo Studies of Drug BBB Transport:: Translational Challenges and the Role of Brain Imaging

Syvänen, Stina; Hammarlund-Udenaes, Margareta; Loryan, Irena

Part of Handbook of Experimental Pharmacology, 2020.

DOI for In Vivo Studies of Drug BBB Transport:: Translational Challenges and the Role of Brain Imaging
Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

Nyman, Elin; Lindh, Maria; Lövfors, William; Simonsson, Christian et al.

Part of CPT, p. 707-717, 2020.

DOI for Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling Download full text (pdf) of Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

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Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Andronis, Christos; Silva, João Pedro; Lekka, Eftychia; Virvilis, Vassilis et al.

Part of Archives of Toxicology, p. 2829-2845, 2020.

DOI for Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis Download full text (pdf) of Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Open access
Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment

Hu, Yang; Hammarlund-Udenaes, Margareta

Part of Molecular Pharmaceutics, p. 4029-4039, 2020.

DOI for Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment Download full text (pdf) of Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment

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Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

Hamm, Gregory R.; Bäckström, Erica; Brülls, Mikael; Nilsson, Anna et al.

Part of Journal of Aerosol Medicine, p. 43-53, 2020.

DOI for Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging
A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Sulku, Johanna; Jansson, Christer; Melhus, Håkan; Malinovschi, Andrei et al.

Part of The International Journal of Chronic Obstructive Pulmonary Disease, p. 2451-2460, 2019.

DOI for A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden Download full text (pdf) of A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

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Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Mantas, Athanasios; Labbe, Valentine; Loryan, Irena; Mihranyan, Albert

Part of Pharmaceutics, 2019.

DOI for Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility Download full text (pdf) of Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

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Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Colcloughl, Nicola; Chen, Kan; Johnstrom, Peter; Fridén, Markus et al.

Part of Drug Discovery Today, p. 1067-1073, 2019.

DOI for Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery
Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Ganguly, Koustav; Carlander, Ulrika; Garessus, Estella D. G.; Fridén, Markus et al.

Part of Critical reviews in toxicology, p. 160-173, 2019.

DOI for Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data Download full text (pdf) of Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

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Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Part of Scientific Reports, 2019.

DOI for Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development Download full text (pdf) of Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Open access
Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C. M.; Auriola, Seppo et al.

Part of Molecular Pharmaceutics, p. 3261-3274, 2019.

DOI for Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

Schou, Magnus; Ewing, Par; Cselenyi, Zsolt; Fridén, Markus et al.

Part of EJNMMI Research, 2019.

DOI for Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator Download full text (pdf) of Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

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Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Yusof, Siti R; Mohd Uzid, Mahathir; Teh, Eng-Huat; Hanapi, Nur Aziah et al.

Part of Addiction Biology, p. 935-945, 2019.

DOI for Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Open access
Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?

Hu, Yang; Gaillard, Pieter J.; De lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta

Part of European journal of pharmaceutics and biopharmaceutics, p. 197-204, 2019.

DOI for Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?
Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling.

Hu, Yang; Hammarlund-Udenaes, Margareta; Fridén, Markus

Part of Journal of Pharmaceutical Sciences, p. 3425-3433, 2019.

DOI for Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling.
Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Part of Neuropharmacology, p. 1-9, 2018.

DOI for Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy Download full text (pdf) of Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

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In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine

Hu, Yang; Gaillard, Pieter J.; Rip, Jaap; De lange, Elizabeth C.M. et al.

Part of Molecular Pharmaceutics, p. 5493-5500, 2018.

DOI for In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine
Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

Gustafsson, Sofia; Lindström, Veronica; Ingelsson, Martin; Hammarlund-Udenaes, Margareta et al.

Part of Neuropharmacology, p. 482-491, 2018.

DOI for Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology Download full text (pdf) of Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

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Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Part of European Journal of Pharmaceutical Sciences, p. 77-84, 2018.

DOI for Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Boger, Elin; Fridén, Markus

Part of Journal of Aerosol Medicine, p. 1-12, 2018.

DOI for Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms
Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Part of European Journal of Pharmaceutical Sciences, p. 182-187, 2018.

DOI for Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State
Uncovering the regional localization of inhaled salmeterol retention in the lung

Bäckström, Erica; Hamm, Gregory; Nilsson, Anna; Fihn, Britt-Marie et al.

Part of Drug Delivery, p. 838-845, 2018.

DOI for Uncovering the regional localization of inhaled salmeterol retention in the lung Download full text (pdf) of Uncovering the regional localization of inhaled salmeterol retention in the lung

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Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Ericsson, Therese; Fridén, Markus; Kärrman-Mårdh, Carina; Dainty, Ian et al.

Part of Pharmaceutical research, p. 2557-2567, 2017.

DOI for Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data
Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Gustafsson, Sofia; Eriksson, Jonas; Syvänen, Stina; Eriksson, Olof et al.

Part of NeuroImage, p. 177-186, 2017.

DOI for Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations
Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

Ehrhardt, Carsten; Backman, Per; Couet, William; Edwards, Chris et al.

Part of Journal of Pharmaceutical Sciences, p. 2234-2244, 2017.

DOI for Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Greenwood, John; Hammarlund-Udenaes, Margareta; Jones, Hazel C.; Stitt, Alan W. et al.

Part of Fluids and Barriers of the CNS, 2017.

DOI for Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017 Download full text (pdf) of Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

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Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

Chen, Xiaomei; Keep, Richard F.; Liang, Yan; Zhu, Hao-Jie et al.

Part of Biochemical Pharmacology, p. 89-97, 2017.

DOI for Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study
Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review

Hammarlund-Udenaes, Margareta

Part of AAPS Journal, p. 1294-1303, 2017.

DOI for Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review Download full text (pdf) of Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review

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Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

Kusuhara, Hiroyuki; Obach, R. Scott; Rostami-Hodjegan, Amin; Pang, K. Sandy et al.

Part of Journal of Pharmaceutical Sciences, p. 2188-2194, 2017.

DOI for Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist
Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Loryan, Irena; Hoppe, Edmund; Hansen, Klaus; Held, Felix et al.

Part of Molecular Pharmaceutics, p. 4362-4373, 2017.

DOI for Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development
Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

Agrawal, Mukta; Ajazuddin, A; Tripathi, Dulal K.; Saraf, Swarnlata et al.

Part of Journal of Controlled Release, p. 61-77, 2017.

DOI for Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease
Revisiting atenolol as a low passive permeability marker

Chen, Xiaomei; Slättengren, Tim; de Lange, Elizabeth C. M.; Smith, David E. et al.

Part of Fluids and Barriers of the CNS, 2017.

DOI for Revisiting atenolol as a low passive permeability marker Download full text (pdf) of Revisiting atenolol as a low passive permeability marker

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The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study

Hu, Yang; Rip, Jaap; Gaillard, Pieter J.; de lange, Elizabeth C. M. et al.

Part of Journal of Pharmaceutical Sciences, p. 2606-2613, 2017.

DOI for The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study
Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Bäckström, Erica; Lundqvist, Anders; Boger, Elin; Svanberg, Petter et al.

Part of Journal of Pharmaceutical Sciences, p. 838-845, 2016.

DOI for Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds
Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

Lindqvist, Annika; Jönsson, Siv; Hammarlund-Udenaes, Margareta

Part of Molecular Pharmaceutics, p. 1258-1266, 2016.

DOI for Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling
Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

Melander, Erik; Eriksson, Camilla; Jansson, Britt; Göransson, Ulf et al.

Part of Biopolymers, p. 910-916, 2016.

DOI for Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate Download full text (pdf) of Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

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In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes

Lindqvist, Annika; Rip, Jaap; van Kregten, Joan; Gaillard, Pieter J et al.

Part of Pharmaceutical research, p. 177-185, 2016.

DOI for In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes
In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Part of Molecular Psychiatry, p. 1527-1536, 2016.

DOI for In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy
Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Bäckström, Erica; Boger, Elin; Lundqvist, Anders; Hammarlund-Udenaes, Margareta et al.

Part of Journal of Pharmaceutical Sciences, p. 3432-3439, 2016.

DOI for Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices
Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Lindqvist, Annika; Fridén, Markus; Hammarlund-Udenaes, Margareta

Part of European Journal of Pharmaceutical Sciences, p. 173-182, 2016.

DOI for Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Last modified: 2022-10-10