Recent publications
Publications
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Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)
Part of BMJ Open, 2022.
DOI for Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP) Download full text (pdf) of Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)
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Large-scale WGS of carbapenem-resistant Acinetobacter baumannii isolates reveals patterns of dissemination of ST clades associated with antibiotic resistance
Part of Journal of Antimicrobial Chemotherapy, p. 934-943, 2022.
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Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab
Part of Clinical Cancer Research, p. 1363-1371, 2022.
DOI for Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab Download full text (pdf) of Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab
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Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis
Part of Pharmaceutics, 2022.
DOI for Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis Download full text (pdf) of Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis
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Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial
Part of American Journal of Respiratory and Critical Care Medicine, p. 1228-1235, 2022.
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In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections
Part of Clinical Microbiology and Infection, p. 73-78, 2022.
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Pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following nebulisation of CMS among patients with ventilator-associated pneumonia
Part of International Journal of Antimicrobial Agents, 2022.
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Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial
Part of EClinicalMedicine, 2022.
DOI for Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial Download full text (pdf) of Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial
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Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics
Part of Clinical Microbiology and Infection, p. 448.e1-448.e7, 2022.
DOI for Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics Download full text (pdf) of Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics
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Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application
Part of CPT, p. 991-1001, 2022.
DOI for Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application Download full text (pdf) of Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application
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Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients
Part of Pharmaceutical research, p. 1779-1787, 2022.
DOI for Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients Download full text (pdf) of Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients
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Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin
Part of Pharmaceutics, 2022.
DOI for Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin Download full text (pdf) of Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin
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Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings
Part of Antibiotics, 2022.
DOI for Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings Download full text (pdf) of Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings
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A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study
Part of CPT, p. 628-639, 2022.
DOI for A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study Download full text (pdf) of A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study
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Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance
Part of Scientific Reports, 2022.
DOI for Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance Download full text (pdf) of Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance
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Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma
Part of Journal of clinical pharmacology, p. 905-917, 2022.
DOI for Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma Download full text (pdf) of Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma
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Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data
Part of Journal of Infectious Diseases, p. 1876-1885, 2022.
DOI for Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data Download full text (pdf) of Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data
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Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue: Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations
Part of Pharmaceutical research, p. 1633-1643, 2022.
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Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections
Part of Frontiers in Microbiology, 2022.
DOI for Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections Download full text (pdf) of Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
Part of BMJ Open, 2022.
DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia
Part of Clinical Microbiology and Infection, p. 1367-1374, 2022.
DOI for Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia Download full text (pdf) of Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia
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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose
Part of Journal of Antimicrobial Chemotherapy, p. 2718-2728, 2022.
DOI for Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose Download full text (pdf) of Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose
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Research priorities towards precision antibiotic therapy to improve patient care
Part of LANCET MICROBE, p. e795-e802, 2022.
DOI for Research priorities towards precision antibiotic therapy to improve patient care Download full text (pdf) of Research priorities towards precision antibiotic therapy to improve patient care
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Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia
Part of Journal of Antimicrobial Chemotherapy, p. 2479-2488, 2022.
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Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug
Part of CPT, p. 1628-1637, 2022.
DOI for Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug Download full text (pdf) of Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug
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Pharmacometrics in tuberculosis: progress and opportunities
Part of International Journal of Antimicrobial Agents, 2022.
DOI for Pharmacometrics in tuberculosis: progress and opportunities Download full text (pdf) of Pharmacometrics in tuberculosis: progress and opportunities
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Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects
Part of International Journal of Antimicrobial Agents, 2022.
DOI for Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects Download full text (pdf) of Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects
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Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data
Part of AAPS Journal, 2021.
DOI for Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data Download full text (pdf) of Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data
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A Time-to-Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations
Part of Clinical Pharmacology and Therapeutics, p. 416-423, 2021.
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Model-Informed Drug Development for Anti-Infectives: State of the Art and Future
Part of Clinical Pharmacology and Therapeutics, p. 867-891, 2021.
DOI for Model-Informed Drug Development for Anti-Infectives: State of the Art and Future Download full text (pdf) of Model-Informed Drug Development for Anti-Infectives: State of the Art and Future
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Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity
Part of BMC Infectious Diseases, 2021.
DOI for Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity Download full text (pdf) of Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity
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Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety
Part of Pharmaceutical research, p. 593-605, 2021.
DOI for Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety Download full text (pdf) of Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety
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Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial
Part of AAPS Journal, 2021.
DOI for Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial Download full text (pdf) of Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial
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CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision
Part of CPT, p. 649-657, 2021.
DOI for CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision Download full text (pdf) of CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision
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Pivotal Role of Translation in Anti-Infective Development
Part of Clinical Pharmacology and Therapeutics, p. 856-866, 2021.
DOI for Pivotal Role of Translation in Anti-Infective Development Download full text (pdf) of Pivotal Role of Translation in Anti-Infective Development
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Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
Part of Clinical Pharmacology and Therapeutics, p. 1063-1073, 2021.
DOI for Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin Download full text (pdf) of Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
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Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.
Part of European Respiratory Journal, 2021.
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Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice
Part of Clinical Microbiology and Infection, p. 1315-1321, 2021.
DOI for Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice Download full text (pdf) of Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice
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Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model
Part of Journal of Infectious Diseases, p. 1039-1047, 2021.
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Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer
Part of Frontiers in Pharmacology, 2021.
DOI for Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer Download full text (pdf) of Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer
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Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial
Part of Journal of Antimicrobial Chemotherapy, p. 3237-3246, 2021.
DOI for Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial
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Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel
Part of CPT, p. 1255-1266, 2021.
DOI for Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel Download full text (pdf) of Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel
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Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel
Part of CPT, p. 511-521, 2021.
DOI for Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel Download full text (pdf) of Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel
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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
Part of EBioMedicine, 2021.
DOI for Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis Download full text (pdf) of Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
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Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium
Part of Clinical Pharmacology in Drug Development, p. 220-228, 2021.
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Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
Part of Cancer Reports, 2021.
DOI for Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever Download full text (pdf) of Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
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Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy
Part of International Journal of Infectious Diseases, p. 133-140, 2020.
DOI for Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy Download full text (pdf) of Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy