Department of Pharmacy

Department of Pharmacy Research Pharmacometrics Publications

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Recent publications

Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

Ekqvist, David; Bornefall, Anna; Augustinsson, Daniel; Sönnerbrandt, Martina et al.

Part of BMJ Open, 2022.

DOI for Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP) Download full text (pdf) of Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

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Large-scale WGS of carbapenem-resistant Acinetobacter baumannii isolates reveals patterns of dissemination of ST clades associated with antibiotic resistance

Frenk, Sammy; Temkin, Elizabeth; Lurie-Weinberger, Mor N.; Keren-Paz, Alona et al.

Part of Journal of Antimicrobial Chemotherapy, p. 934-943, 2022.

DOI for Large-scale WGS of carbapenem-resistant Acinetobacter baumannii isolates reveals patterns of dissemination of ST clades associated with antibiotic resistance
Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab

Grisic, Ana-Marija; Xiong, Wenyuan; Tanneau, Lénaïg; Jönsson, Siv et al.

Part of Clinical Cancer Research, p. 1363-1371, 2022.

DOI for Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab Download full text (pdf) of Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab

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Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Mockeliunas, Laurynas; Keutzer, Lina; Sturkenboom, Marieke G. G.; Bolhuis, Mathieu S. et al.

Part of Pharmaceutics, 2022.

DOI for Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis Download full text (pdf) of Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

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Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial

De Jager, Veronique; Gupte, Nikhil; Nunes, Silvia; Barnes, Grace L. et al.

Part of American Journal of Respiratory and Critical Care Medicine, p. 1228-1235, 2022.

DOI for Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial
In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections

Nutman, Amir; Temkin, Elizabeth; Lellouche, Jonathan; Rakovitsky, Nadya et al.

Part of Clinical Microbiology and Infection, p. 73-78, 2022.

DOI for In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections
Pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following nebulisation of CMS among patients with ventilator-associated pneumonia

Gkoufa, Aikaterini; Sou, Tomas; Karaiskos, Ilias; Routsi, Christina et al.

Part of International Journal of Antimicrobial Agents, 2022.

DOI for Pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following nebulisation of CMS among patients with ventilator-associated pneumonia
Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial

Upton, Caryn M.; Van Wijk, Rob C; Mockeliunas, Laurynas; Simonsson, Ulrika S. H. et al.

Part of EClinicalMedicine, 2022.

DOI for Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial Download full text (pdf) of Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double- blind, randomised, controlled, phase 3 trial

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Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics

Ruth, Mike Marvin; Raaijmakers, Jelmer; van den Hombergh, Erik; Aarnoutse, Rob et al.

Part of Clinical Microbiology and Infection, p. 448.e1-448.e7, 2022.

DOI for Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics Download full text (pdf) of Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics

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Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application

Van Wijk, Rob C; Simonsson, Ulrika S. H.

Part of CPT, p. 991-1001, 2022.

DOI for Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application Download full text (pdf) of Finding the right hazard function for time-to-event modeling: A tutorial and Shiny application

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Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients

Llanos-Paez, Carolina C.; Ambery, Claire; Yang, Shuying; Beerahee, Misba et al.

Part of Pharmaceutical research, p. 1779-1787, 2022.

DOI for Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients Download full text (pdf) of Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients

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Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

Keutzer, Lina; You, Huifang; Farnoud, Ali; Nyberg, Joakim et al.

Part of Pharmaceutics, 2022.

DOI for Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin Download full text (pdf) of Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

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Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings

Minichmayr, Iris; Kappetein, Suzanne; Brill, Margreke J. E.; Friberg, Lena

Part of Antibiotics, 2022.

DOI for Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings Download full text (pdf) of Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings

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A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

Keutzer, Lina; Akhondipour, Yasamin; Forsman, Lina Davies; Simonsson, Ulrika S. H.

Part of CPT, p. 628-639, 2022.

DOI for A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study Download full text (pdf) of A modeling-based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

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Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance

Yin, Anyue; van Hasselt, Johan G. C.; Guchelaar, Henk-Jan; Friberg, Lena et al.

Part of Scientific Reports, 2022.

DOI for Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance Download full text (pdf) of Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance

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Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma

Kotani, Naoki; Dolton, Michael; Svensson, Robin J.; Ribbing, Jakob et al.

Part of Journal of clinical pharmacology, p. 905-917, 2022.

DOI for Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma Download full text (pdf) of Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma

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Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

Mudde, Saskia E.; Ayoun Alsoud, Rami; van der Meijden, Aart; Upton, Anna M. et al.

Part of Journal of Infectious Diseases, p. 1876-1885, 2022.

DOI for Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data Download full text (pdf) of Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data

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Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue: Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations

Öbrink-Hansen, Kristina; Pham, Anh Duc; Bue, Mats; Hanberg, Pelle et al.

Part of Pharmaceutical research, p. 1633-1643, 2022.

DOI for Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue: Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations
Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Part of Frontiers in Microbiology, 2022.

DOI for Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections Download full text (pdf) of Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

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Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1

Sánchez, Javier; Nicolini, Valeria; Fahrni, Linda; Waldhauer, Inja et al.

Part of AAPS Journal, 2022.

DOI for Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1
Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022.

DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival Download full text (pdf) of Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

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Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Aranzana-Climent, Vincent; Hughes, Diarmaid; Cao, Sha; Tomczak, Magdalena et al.

Part of Clinical Microbiology and Infection, p. 1367-1374, 2022.

DOI for Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia Download full text (pdf) of Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

Zhao, Chenyan; Chirkova, Anna; Rosenborg, Staffan; Palma Villar, Rodrigo et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2718-2728, 2022.

DOI for Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose Download full text (pdf) of Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

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Research priorities towards precision antibiotic therapy to improve patient care

Bulman, Zackery P.; Wicha, Sebastian G.; Nielsen, Elisabet I.; Lenhard, Justin R. et al.

Part of LANCET MICROBE, p. e795-e802, 2022.

DOI for Research priorities towards precision antibiotic therapy to improve patient care Download full text (pdf) of Research priorities towards precision antibiotic therapy to improve patient care

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Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia

Dreesen, Erwin; Gijsen, Matthias; Elkayal, Omar; Annaert, Pieter et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2479-2488, 2022.

DOI for Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia
Bayesian forecasting of tumor size metrics and overall survival

Krishnan, Sreenath M.; Friberg, Lena E.

Part of CPT, p. 1604-1613, 2022.

DOI for Bayesian forecasting of tumor size metrics and overall survival Download full text (pdf) of Bayesian forecasting of tumor size metrics and overall survival

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Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

Faraj, Alan; Knudsen, Tom; Desai, Shraddha; Neuman, Linda et al.

Part of CPT, p. 1628-1637, 2022.

DOI for Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug Download full text (pdf) of Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

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Pharmacometrics in tuberculosis: progress and opportunities

Wilkins, Justin J.; Svensson, Elin; Ernest, Jacqueline P.; Savic, Radojka M. et al.

Part of International Journal of Antimicrobial Agents, 2022.

DOI for Pharmacometrics in tuberculosis: progress and opportunities Download full text (pdf) of Pharmacometrics in tuberculosis: progress and opportunities

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Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects

Minichmayr, Iris; Aranzana-Climent, Vincent; Friberg, Lena

Part of International Journal of Antimicrobial Agents, 2022.

DOI for Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects Download full text (pdf) of Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects

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Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.

Part of AAPS Journal, 2021.

DOI for Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data Download full text (pdf) of Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

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A Time-to-Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations

Germovsek, Eva; Hansson, Anna; Karlsson, Mats O.; Westin, Ake et al.

Part of Clinical Pharmacology and Therapeutics, p. 416-423, 2021.

DOI for A Time-to-Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations

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Model-Informed Drug Development for Anti-Infectives: State of the Art and Future

Rayner, Craig R.; Smith, Patrick F.; Andes, David; Andrews, Kayla et al.

Part of Clinical Pharmacology and Therapeutics, p. 867-891, 2021.

DOI for Model-Informed Drug Development for Anti-Infectives: State of the Art and Future Download full text (pdf) of Model-Informed Drug Development for Anti-Infectives: State of the Art and Future

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Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity

Daitch, Vered; Paul, Mical; Daikos, George L.; Durante-Mangoni, Emanuele et al.

Part of BMC Infectious Diseases, 2021.

DOI for Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity Download full text (pdf) of Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity

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Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

Minichmayr, Iris K.; Karlsson, Mats O.; Jönsson, Siv

Part of Pharmaceutical research, p. 593-605, 2021.

DOI for Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety Download full text (pdf) of Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

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Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial

Llanos-Paez, Carolina; Ambery, Claire; Yang, Shuying; Tabberer, Maggie et al.

Part of AAPS Journal, 2021.

DOI for Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial Download full text (pdf) of Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial

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CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision

Rowland Yeo, Karen; Hennig, Stefanie; Krishnaswami, Sriram; Strydom, Natasha et al.

Part of CPT, p. 649-657, 2021.

DOI for CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision Download full text (pdf) of CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision

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Pivotal Role of Translation in Anti-Infective Development

Friberg, Lena E.

Part of Clinical Pharmacology and Therapeutics, p. 856-866, 2021.

DOI for Pivotal Role of Translation in Anti-Infective Development Download full text (pdf) of Pivotal Role of Translation in Anti-Infective Development

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Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria et al.

Part of Clinical Pharmacology and Therapeutics, p. 1063-1073, 2021.

DOI for Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin Download full text (pdf) of Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

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Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin et al.

Part of European Respiratory Journal, 2021.

DOI for Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

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Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna et al.

Part of Clinical Microbiology and Infection, p. 1315-1321, 2021.

DOI for Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice Download full text (pdf) of Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

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Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel

van Doorn, Leni; van Rosmalen, Mandy M.; van der Deure, Wendy M.; Oomen-de Hoop, Esther et al.

Part of Cancers, 2021.

DOI for Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel Download full text (pdf) of Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel

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Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model

Pieterman, Elise D.; Keutzer, Lina; van der Meijden, Aart; van den Berg, Sanne et al.

Part of Journal of Infectious Diseases, p. 1039-1047, 2021.

DOI for Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model
Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

van Eerden, Ruben A. G.; van Doorn, Leni; de Man, Femke M.; Heersche, Niels et al.

Part of Frontiers in Pharmacology, 2021.

DOI for Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer Download full text (pdf) of Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer

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Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial

Garcia-Prats, Anthony J.; Svensson, Elin; Winckler, Jana; Draper, Heather R. et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3237-3246, 2021.

DOI for Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial
Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel

Krishnan, Sreenath M.; Friberg, Lena E.; Bruno, René; Beyer, Ulrich et al.

Part of CPT, p. 1255-1266, 2021.

DOI for Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel Download full text (pdf) of Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel

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Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel

Krishnan, Sreenath Madathil; Laarif, Sofiene S.; Bender, Brendan C.; Quartino, Angelica L. et al.

Part of CPT, p. 511-521, 2021.

DOI for Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel Download full text (pdf) of Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel

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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Becker, Katja; Cao, Sha; Nilsson, Anna; Erlandsson, Maria et al.

Part of EBioMedicine, 2021.

DOI for Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis Download full text (pdf) of Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

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Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium

Sharan, Satish; Fang, Lanyan; Lukacova, Viera; Chen, Xiaomei et al.

Part of Clinical Pharmacology in Drug Development, p. 220-228, 2021.

DOI for Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium
Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Maarbjerg, Sabine F.; Thorsted, Anders; Friberg, Lena; Nielsen, Elisabet I. et al.

Part of Cancer Reports, 2021.

DOI for Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever Download full text (pdf) of Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

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Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy

Bue, Mats; Sou, Tomás; Okkels, Anna S. L.; Hanberg, Pelle et al.

Part of International Journal of Infectious Diseases, p. 133-140, 2020.

DOI for Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy Download full text (pdf) of Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy

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