Publications from the Bergström group

Early recognition of absorption challenges of contemporary targets:: key molecular properties and in silico tools

Bergström, Christel A S

Part of Bulletin Technique Gattefossé, p. 50-57, 2013.

Computational modeling to predict the functions and impact of drug transporters

Matsson, Pär; Bergström, Christel A S

Part of In silico pharmacology, 2015.

DOI for Computational modeling to predict the functions and impact of drug transporters Download full text (pdf) of Computational modeling to predict the functions and impact of drug transporters

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Persson, Linda C.; Bergström, Christel A S

Part of Current molecular biology reports, p. 141-147, 2015.

DOI for Models for Predicting Drug Absorption From Oral Lipid-Based Formulations Download full text (pdf) of Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Fagerberg, Jonas H; Bergström, Christel A S

Part of Therapeutic delivery, p. 935-959, 2015.

DOI for Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Alhalaweh, Amjad; Alzghoul, Ahmad; Mahlin, Denny; Bergström, Christel A. S.

Part of International Journal of Pharmaceutics, p. 312-317, 2015.

DOI for Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Download full text (pdf) of Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Alzghoul, Ahmad; Alhalaweh, Amjad; Mahlin, Denny; Bergström, Christel A. S.

Part of JOURNAL OF CHEMICAL INFORMATION AND MODELING, p. 3396-3403, 2014.

DOI for Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pedersen, Christian; Slepenkin, Anatoly; Andersson, Sara B. E.; Fagerberg, Jonas H. et al.

Part of PLOS ONE, p. e110918-, 2014.

DOI for Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis Download full text (pdf) of Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna et al.

Part of Journal of Medicinal Chemistry, p. 6393-6402, 2014.

DOI for Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Alhalaweh, Amjad; Alzghoul, Ahmad; Kaialy, Waseem; Mahlin, Denny et al.

Part of Molecular Pharmaceutics, p. 3123-3132, 2014.

DOI for Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014.

DOI for Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Is the full potential of the biopharmaceutics classification system reached?

Bergström, Christel A. S.; Andersson, Sara B. E.; Fagerberg, Jonas H.; Ragnarsson, Gert et al.

Part of European Journal of Pharmaceutical Sciences, p. 224-231, 2014.

DOI for Is the full potential of the biopharmaceutics classification system reached?

Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Fagerberg, Jonas H.; Karlsson, Eva; Ulander, Johan; Hanisch, Gunilla et al.

Part of Pharmaceutical research, p. 578-589, 2015.

DOI for Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid Download full text (pdf) of Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 12-20, 2015.

DOI for Concomitant intake of alcohol may increase the absorption of poorly soluble drugs Download full text (pdf) of Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Persson, Linda C.; Porter, Christopher J. H.; Charman, William N.; Bergström, Christel A. S.

Part of Pharmaceutical research, p. 3225-3237, 2013.

DOI for Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Download full text (pdf) of Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Warren, Dallas B.; Bergström, Christel A. S.; Benameur, Hassan; Porter, Christopher J. H. et al.

Part of Molecular Pharmaceutics, p. 2823-2848, 2013.

DOI for Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Part of Toxicological Sciences, p. 328-343, 2013.

DOI for Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Download full text (pdf) of Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Early drug development predictions of glass-forming ability and physical stability of drugs

Mahlin, Denny; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 323-332, 2013.

DOI for Early drug development predictions of glass-forming ability and physical stability of drugs Download full text (pdf) of Early drug development predictions of glass-forming ability and physical stability of drugs

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013.

DOI for Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Bergstrom, Christel A. S.; Charman, Susan A.; Nicolazzo, Joseph A.

Part of Pharmaceutical research, p. 3131-3142, 2012.

DOI for Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Fagerberg, Jonas H.; Al-Tikriti, Yassir; Ragnarsson, Gert; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 1942-1952, 2012.

DOI for Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011.

DOI for Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Mahlin, Denny; Ponnambalam, Sopana; Hockerfelt, Mina Heidarian; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 498-506, 2011.

DOI for Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010.

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H.; Tsinman, Oksana; Sun, Na; Tsinman, Konstantin et al.

Part of Molecular pharmaceutics, p. 1419-1430, 2010.

DOI for Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Part of Molecular pharmaceutics, p. 1478-1487, 2010.

DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.

DOI for Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Part of Pharmaceutical research, p. 1816-1831, 2009.

DOI for Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012.

DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Prediction of ADMET Properties

Norinder, Ulf; Bergström, Christel

Part of ChemMedChem, p. 920-937, 2006.

DOI for Prediction of ADMET Properties

Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Bergström, Christel

Part of Expert opinion on drug metabolism & toxicology, p. 613-627, 2005.

DOI for Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Part of Clinical Pharmacokinetics, p. 877-899, 2002.

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008.

DOI for Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008.

DOI for Molecular characteristics for solid-state limited solubility

Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Aziz, Emad F; Gråsjö, Johan; Forsberg, Johan; Andersson, Egil et al.

Part of Journal of Physical Chemistry A, p. 9662-9669, 2007.

DOI for Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008.

DOI for Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007.

DOI for A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Poorly soluble marketed drugs display solvation limited solubility

Bergström, Christel; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina

Part of Journal of Medicinal Chemistry, p. 5858-5862, 2007.

DOI for Poorly soluble marketed drugs display solvation limited solubility

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Part of J Electr Spectr, p. 283-285, 2005.

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Part of Eur J Pharm Sci, p. 294-305, 2006.

Prediction of ADMET Properties.

Norinder, U; Bergström, C

Part of ChemMedChem, p. 920-937, 2006.