Publications from the Bergström group

Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations

Andreadis, Ioannis I.; Schulzen, Arne; Quodbach, Julian; Bergström, Christel

Part of European Journal of Pharmaceutical Sciences, 2023.

DOI for Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations Download full text (pdf) of Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations

Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms

Johannesson, Jenny; Pathare, Malhar Manik; Johansson, Mathias; Bergström, Christel et al.

Part of Journal of Colloid and Interface Science, p. 1253-1264, 2023.

DOI for Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms Download full text (pdf) of Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms

Magnetoresponsive fluorescent core-shell nanoclusters for biomedical applications

Saladino, Giovanni Marco; Kakadiya, Ronak; Ansari, Shaquib Rahman; Teleki, Alexandra et al.

Part of Nanoscale Advances, p. 1323-1330, 2023.

DOI for Magnetoresponsive fluorescent core-shell nanoclusters for biomedical applications Download full text (pdf) of Magnetoresponsive fluorescent core-shell nanoclusters for biomedical applications

Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer

Naranjani, Benyamin; Sinko, Patrick D.; Bergström, Christel; Gogoll, A et al.

Part of International Journal of Biological Macromolecules, 2023.

DOI for Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer Download full text (pdf) of Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer

Pickering emulsion gel enables 3D printing of lipid-rich solid oral dosage forms

Johannesson, Jenny; Pathare, Malhar Manik; Johansson, Mathias; Bergström, Christel et al.

Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs

Barmpatsalou, Vicky; Rodler, Agnes; Jacobson, Magdalena; Karlsson, Eva Marie-Louise et al.

Part of European Journal of Pharmaceutical Sciences, 2023.

DOI for Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs Download full text (pdf) of Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs

Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Kabedev, Aleksei; Zhuo, Xuezhi; Leng, Donglei; Foderà, Vito et al.

Part of Molecular Pharmaceutics, p. 3922-3933, 2022.

DOI for Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin Download full text (pdf) of Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives

Asad, Shno; Jacobsen, Ann-Christin; Teleki, Alexandra

Part of Current Opinion in Chemical Engineering, 2022.

DOI for Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives Download full text (pdf) of Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives

Intrinsic lipolysis rate for systematic design of lipid-based formulations

Jacobsen, Ann-Christin; Kabedev, Aleksei; Sinko, Patrick D.; Palm, Johan E. et al.

Part of Drug Delivery and Translational Research, 2022.

DOI for Intrinsic lipolysis rate for systematic design of lipid-based formulations Download full text (pdf) of Intrinsic lipolysis rate for systematic design of lipid-based formulations

Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers

Berg, Staffan; Edlund, Helena; Goundry, William R. F.; Bergström, Christel et al.

Part of International Journal of Pharmaceutics, 2022.

DOI for Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers

Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 451-460, 2023.

DOI for Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs Download full text (pdf) of Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs

Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation

Zardán Gómez de la Torre, Teresa; Lindmark, Tuulikki; Cheung, Ocean; Bergström, Christel et al.

Part of Molecules, 2022.

DOI for Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation Download full text (pdf) of Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation

Membrane insertion mechanism of the caveola coat protein Cavin1

Liu, Kang-Cheng; Pace, Hudson; Larsson, Elin; Hossain, Md Shakhawath et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022.

DOI for Membrane insertion mechanism of the caveola coat protein Cavin1 Download full text (pdf) of Membrane insertion mechanism of the caveola coat protein Cavin1

Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model

Berg, Staffan; Suljovic, Denny; Kärrberg, Lillevi; Englund, Maria et al.

Part of Molecular Pharmaceutics, p. 2564-2572, 2022.

DOI for Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model Download full text (pdf) of Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model

Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms

Ansari, Shaquib; Hempel, Nele-Johanna; Asad, Shno; Svedlindh, Peter et al.

Part of ACS Applied Materials and Interfaces, p. 21978-21988, 2022.

DOI for Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms Download full text (pdf) of Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms

Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Dubbelboer, Ilse R; Barmpatsalou, Vicky; Rodler, Agnes; Karlsson, Eva et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 92-102, 2022.

DOI for Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by H-1 NMR and All-Atom Molecular Dynamics Simulations

Hjalte, Johanna; Hossain, Md Shakhawath; Hugerth, Andreas; Sjogren, Helen et al.

Part of Molecular Pharmaceutics, p. 904-917, 2022.

DOI for Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by H-1 NMR and All-Atom Molecular Dynamics Simulations Download full text (pdf) of Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by H-1 NMR and All-Atom Molecular Dynamics Simulations

Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat

Berg, Staffan; Karrberg, Lillevi; Suljovic, Denny; Seeliger, Frank et al.

Part of Molecular Pharmaceutics, p. 200-212, 2022.

DOI for Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat Download full text (pdf) of Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat

Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms

Johannesson, Jenny; Hansson, Paula; Bergström, Christel; Paulsson, Mattias

Part of Biomedicine and Pharmacotherapy, p. 112576-112576, 2022.

DOI for Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms Download full text (pdf) of Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms

Explicit-pH Coarse-Grained Molecular Dynamics Simulations Enable Insights into Restructuring of Intestinal Colloidal Aggregates with Permeation Enhancers

Hossain, Md Shakhawath; Parrow, Albin; Kabedev, Aleksei; Kneiszl, Rosita C. et al.

Part of Processes, p. 29-, 2022.

DOI for Explicit-pH Coarse-Grained Molecular Dynamics Simulations Enable Insights into Restructuring of Intestinal Colloidal Aggregates with Permeation Enhancers Download full text (pdf) of Explicit-pH Coarse-Grained Molecular Dynamics Simulations Enable Insights into Restructuring of Intestinal Colloidal Aggregates with Permeation Enhancers

In Silico-Based Experiments on Mechanistic Interactions between Several Intestinal Permeation Enhancers with a Lipid Bilayer Model

Kneiszl, Rosita C.; Hossain, Md Shakhawath; Larsson, Per

Part of Molecular Pharmaceutics, p. 124-137, 2022.

DOI for In Silico-Based Experiments on Mechanistic Interactions between Several Intestinal Permeation Enhancers with a Lipid Bilayer Model Download full text (pdf) of In Silico-Based Experiments on Mechanistic Interactions between Several Intestinal Permeation Enhancers with a Lipid Bilayer Model

Sustainability in drug discovery

Wynendaele, Evelien; Furman, Christophe; Wielgomas, Bartosz; Larsson, Per et al.

Part of Medicine in Drug Discovery, 2021.

DOI for Sustainability in drug discovery Download full text (pdf) of Sustainability in drug discovery

Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations

Edueng, Khadijah; Kabedev, Aleksei; Ekdahl, Alyssa; Mahlin, Denny et al.

Part of International Journal of Pharmaceutics, 2021.

DOI for Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations

Celebrating Women in the Pharmaceutical Sciences

Taylor, Lynne S.; Bergström, Christel; Lavasanifar, Afsaneh; Qian, Feng et al.

Part of Molecular Pharmaceutics, p. 1487-1490, 2021.

DOI for Celebrating Women in the Pharmaceutical Sciences

UNGAP best practice for improving solubility data quality of orally administered drugs

Vertzoni, M.; Alsenz, J.; Augustijns, P.; Bauer-Brandl, A. et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

DOI for UNGAP best practice for improving solubility data quality of orally administered drugs Download full text (pdf) of UNGAP best practice for improving solubility data quality of orally administered drugs

Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel

Part of Molecular Pharmaceutics, p. 4079-4089, 2021.

DOI for Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations Download full text (pdf) of Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Barmpatsalou, Vicky; Dubbelboer, Ilse R; Rodler, Agnes; Jacobson, Magdalena et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 156-167, 2021.

DOI for Physiological properties, composition and structural profiling of porcine gastrointestinal mucus Download full text (pdf) of Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate

Gómez de la Torre, Johan; Bergström, Christel; Zardán Gómez de la Torre, Teresa

Part of Molecules, 2021.

DOI for Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate Download full text (pdf) of Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate

Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Part of ACS INFECTIOUS DISEASES, p. 2666-2685, 2021.

DOI for Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa Download full text (pdf) of Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

Getting a grip with kirigami

Teleki, Alexandra; Artursson, Per

Part of Nature Materials, p. 1043-1044, 2021.

DOI for Getting a grip with kirigami

Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay

Keemink, Janneke; Hedge, Oliver; Bianco, Valentina; Hubert, Madlen et al.

Part of Journal of Pharmaceutical Sciences, p. 175-184, 2022.

DOI for Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay Download full text (pdf) of Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay

Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine

Hedge, Oliver; Höök, Fredrik; Joyce, Paul; Bergström, Christel

Part of Langmuir, p. 10200-10213, 2021.

DOI for Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine Download full text (pdf) of Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine

The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization

Hempel, Nele-Johanna; Merkl, Padryk; Knopp, Matthias Manne; Berthelsen, Ragna et al.

Part of Molecules, 2021.

DOI for The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization Download full text (pdf) of The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization

Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

Hempel, Nele-Johanna; Merkl, Padryk; Asad, Shno; Knopp, Matthias Manne et al.

Part of Molecular Pharmaceutics, p. 2254-2262, 2021.

DOI for Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

The Influence of Drug-Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

Hempel, Nele-Johanna; Merkl, Padryk; Knopp, Matthias Manne; Berthelsen, Ragna et al.

Part of Pharmaceutics, 2021.

DOI for The Influence of Drug-Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles Download full text (pdf) of The Influence of Drug-Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

3D-printing of solid lipid tablets from emulsion gels

Johannesson, Jenny; Khan, Jamal; Hubert, Madlen; Teleki, Alexandra et al.

Part of International Journal of Pharmaceutics, 2021.

DOI for 3D-printing of solid lipid tablets from emulsion gels Download full text (pdf) of 3D-printing of solid lipid tablets from emulsion gels

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021.

DOI for Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease Download full text (pdf) of Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

Kuentz, Martin; Bergström, Christel A.S.

Part of Journal of Pharmaceutical Sciences, p. 22-34, 2021.

DOI for Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B. et al.

Part of Journal of Pharmaceutical Sciences, p. 2-11, 2021.

DOI for A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin et al.

Part of Journal of Pharmaceutical Sciences, p. 228-238, 2021.

DOI for In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per et al.

Part of Journal of Pharmaceutical Sciences, p. 176-185, 2021.

DOI for Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation Download full text (pdf) of Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J. et al.

Part of ACS Omega, p. 25733-25746, 2020.

DOI for Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions Download full text (pdf) of Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

Bergström, Christel; Llinas, Antonio

Part of ADMET & DMPK, p. 176-179, 2020.

DOI for Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds Download full text (pdf) of Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

Wright, Leah; Joyce, Paul; Barnes, Timothy J.; Lundmark, Richard et al.

Part of Journal of Pharmaceutical Sciences, p. 217-227, 2021.

DOI for A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

Contemporary formulation development for inhaled pharmaceuticals

Sou, Tomás; Bergström, Christel A. S.

Part of Journal of Pharmaceutical Sciences, p. 66-86, 2021.

DOI for Contemporary formulation development for inhaled pharmaceuticals Download full text (pdf) of Contemporary formulation development for inhaled pharmaceuticals

TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath et al.

Part of Angewandte Chemie International Edition, p. 2069-2073, 2021.

DOI for TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica Download full text (pdf) of TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 4018-4028, 2020.

DOI for Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver et al.

Part of Molecular Pharmaceutics, p. 4226-4240, 2020.

DOI for Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers Download full text (pdf) of Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 3837-3844, 2020.

DOI for Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization Download full text (pdf) of Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Automated assays for thermodynamic (equilibrium) solubility determination.

Sou, Tomás; Bergström, Christel

Part of Drug Discovery Today, p. 11-19, 2018.

DOI for Automated assays for thermodynamic (equilibrium) solubility determination.

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

Part of Pharmaceutics, 2020.

DOI for Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media Download full text (pdf) of Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik

Part of Journal of Computational Chemistry, p. 1564-1569, 2020.

DOI for MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N. et al.

Part of Frontiers in Chemistry, 2020.

DOI for Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa Download full text (pdf) of Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Part of Pharmaceutics, 2020.

DOI for Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions Download full text (pdf) of Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean et al.

Part of Pharmaceutics, 2020.

DOI for In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier Download full text (pdf) of In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena et al.

Part of Molecular Pharmaceutics, p. 1458-1469, 2020.

DOI for Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 21-29, 2020.

DOI for An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems Download full text (pdf) of An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Hedge, Oliver; Bergström, Christel A. S.

Part of Pharmaceutical research, 2020.

DOI for Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations Download full text (pdf) of Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E. et al.

Part of AAPS Journal, 2020.

DOI for Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties Download full text (pdf) of Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

Part of Molecular Pharmaceutics, p. 4636-4650, 2019.

DOI for The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin et al.

Part of European Journal of Pharmaceutical Sciences, 2019.

DOI for Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems Download full text (pdf) of Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Part of Journal of Pharmaceutical Sciences, p. 1765-1771, 2019.

DOI for Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs? Download full text (pdf) of Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

Part of International Journal of Pharmaceutics, p. 264-281, 2019.

DOI for The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

Part of Pharmaceutics, 2019.

DOI for Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia et al.

Part of Molecules, 2019.

DOI for Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage Download full text (pdf) of Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 101-114, 2019.

DOI for Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

Perspectives in solubility measurement and interpretation

Bergström, Christel A.S.; Avdeef, Alex

Part of ADMET AND DMPK, p. 88-105, 2019.

DOI for Perspectives in solubility measurement and interpretation Download full text (pdf) of Perspectives in solubility measurement and interpretation

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 46-55, 2019.

DOI for Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning Download full text (pdf) of Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Keemink, Janneke; Martensson, Elin; Bergström, Christel

Part of Molecular Pharmaceutics, p. 921-930, 2019.

DOI for Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro Download full text (pdf) of Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

Part of Journal of Pharmaceutical Sciences, p. 630-640, 2019.

DOI for Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection Download full text (pdf) of Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.

Part of Journal of Pharmaceutical Sciences, p. 252-259, 2019.

DOI for Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions Download full text (pdf) of Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S. et al.

Part of Journal of Pharmaceutical Sciences, p. 2-7, 2019.

DOI for Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Hossain, Md Shakhawath; Berg, Staffan; Bergström, Christel; Larsson, Per

Part of AAPS PharmSciTech, 2019.

DOI for Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation Download full text (pdf) of Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Alskär, Linda C.; Parrow, Albin; Keemink, Janneke; Pernilla, Johansson et al.

Part of Journal of Controlled Release, p. 90-100, 2019.

DOI for Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation? Download full text (pdf) of Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Alskär, Linda C.; Keemink, Janneke; Johannesson, Jenny; Porter, Christopher J H et al.

Part of Molecular Pharmaceutics, p. 4733-4744, 2018.

DOI for Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations Download full text (pdf) of Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

Tsume, Yasuhiro; Patel, Sanjaykumar; Fotaki, Nikoletta; Bergström, Christel et al.

Part of AAPS Journal, 2018.

DOI for In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

Emulsions Stabilized by Chitosan-Modified Silica Nanoparticles: pH Control of Structure-Property Relations

Alison, Lauriane; Demirörs, Ahmet F; Tervoort, Elena; Teleki, Alexandra et al.

Part of Langmuir, p. 6147-6160, 2018.

DOI for Emulsions Stabilized by Chitosan-Modified Silica Nanoparticles: pH Control of Structure-Property Relations

A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions

Alvebratt, Caroline; Cheung, Ocean; Strömme, Maria; Bergström, Christel A. S.

Part of AAPS PharmSciTech, p. 2859-2865, 2018.

DOI for A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions Download full text (pdf) of A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions

Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen

Yang, Jiaojiao; Alvebratt, Caroline; Lu, Xi; Bergström, Christel et al.

Part of International Journal of Pharmaceutics, p. 515-521, 2018.

DOI for Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen

Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

Bergström, Christel A S; Larsson, Per

Part of International Journal of Pharmaceutics, p. 185-193, 2018.

DOI for Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting Download full text (pdf) of Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Keemink, Janneke; Bergström, Christel

Part of Pharmaceutical research, 2018.

DOI for Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations Download full text (pdf) of Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Edueng, Khadijah; Mahlin, Denny; Bergström, Christel

Part of Pharmaceutical Research, p. 1754-1772, 2017.

DOI for The Need for Restructuring the Disordered Science of Amorphous Drug Formulations Download full text (pdf) of The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Clulow, Andrew J.; Parrow, Albin; Hawley, Adrian; Khan, Jamal et al.

Part of Journal of Physical Chemistry B, p. 10869-10881, 2017.

DOI for Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid Download full text (pdf) of Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

Plum, Jakob; Madsen, Cecilie M.; Teleki, Alexandra; Bevernage, Jan et al.

Part of Molecular Pharmaceutics, p. 4161-4169, 2017.

DOI for Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds

Andersson, Sara B. E.; Alvebratt, Caroline; Bergström, Christel

Part of Pharmaceutical research, p. 1805-1816, 2017.

DOI for Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds Download full text (pdf) of Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds

Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Larsson, Per; Alskär, Linda C.; Bergström, Christel

Part of Molecular Pharmaceutics, p. 4145-4153, 2017.

DOI for Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach Download full text (pdf) of Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Edueng, Khadijah; Mahlin, Denny; Larsson, Per; Bergström, Christel

Part of Journal of Controlled Release, p. 193-202, 2017.

DOI for Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways Download full text (pdf) of Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Pedersen, Jenny M.; Khan, Elin K.; Bergström, Christel; Palm, Johan et al.

Part of European Journal of Pharmaceutical Sciences, p. 70-76, 2017.

DOI for Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers

Yang, Jiaojiao; Alvebratt, Caroline; Zhang, Peng; Zardán Gómez de la Torre, Teresa et al.

Part of International Journal of Pharmaceutics, p. 183-190, 2017.

DOI for Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Holmboe, Michael; Larsson, Per; Anwar, Jamshed; Bergström, Christel

Part of Langmuir, p. 12732-12740, 2016.

DOI for Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations Download full text (pdf) of Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Gautschi, Nicolas; Bergström, Christel; Kuentz, Martin

Part of International Journal of Pharmaceutics, p. 164-174, 2016.

DOI for Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Lipophilicity in Drug Development: Too Much or Not Enough?

Bergström, Christel A. S.; Yazdanian, Mehran

Part of AAPS Journal, p. 1095-1100, 2016.

DOI for Lipophilicity in Drug Development: Too Much or Not Enough?

Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Welch, Ken; Bergström, Christel et al.

Part of European Journal of Pharmaceutical Sciences, p. 468-474, 2016.

DOI for Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Bergström, Christel A. S.; Porter, Christopher J. H.

Part of Advanced Drug Delivery Reviews, p. 1-5, 2016.

DOI for Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Feeney, Orlagh M; Crum, Matthew F; McEvoy, Claire L; Trevaskis, Natalie L et al.

Part of Advanced Drug Delivery Reviews, p. 167-194, 2016.

DOI for 50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Andersson, Sara B. E.; Alvebratt, Caroline; Bevernage, Jan; Bonneau, Damien et al.

Part of Journal of Pharmaceutical Sciences, p. 2864-2872, 2016.

DOI for Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergström, Christel A. S.; Charman, William N; Porter, Christopher J H

Part of Advanced Drug Delivery Reviews, p. 6-21, 2016.

DOI for Computational prediction of formulation strategies for beyond-rule-of-5 compounds Download full text (pdf) of Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Alhalaweh, Amjad; Bergström, Christel A. S.; Taylor, Lynne S.

Part of Journal of Controlled Release, p. 172-182, 2016.

DOI for Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Early recognition of absorption challenges of contemporary targets:: key molecular properties and in silico tools

Bergström, Christel A S

Part of Bulletin Technique Gattefossé, p. 50-57, 2013.

Computational modeling to predict the functions and impact of drug transporters

Matsson, Pär; Bergström, Christel A S

Part of In silico pharmacology, 2015.

DOI for Computational modeling to predict the functions and impact of drug transporters Download full text (pdf) of Computational modeling to predict the functions and impact of drug transporters

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Persson, Linda C.; Bergström, Christel A S

Part of Current molecular biology reports, p. 141-147, 2015.

DOI for Models for Predicting Drug Absorption From Oral Lipid-Based Formulations Download full text (pdf) of Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Fagerberg, Jonas H; Bergström, Christel A S

Part of Therapeutic delivery, p. 935-959, 2015.

DOI for Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Alskär, Linda C.; Porter, Christopher J. H.; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 251-261, 2016.

DOI for Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Alhalaweh, Amjad; Alzghoul, Ahmad; Mahlin, Denny; Bergström, Christel A. S.

Part of International Journal of Pharmaceutics, p. 312-317, 2015.

DOI for Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Download full text (pdf) of Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Forsgren, Johan; Bergström, Christel et al.

Part of Journal of Pharmaceutical Sciences, p. 657-663, 2016.

DOI for Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Alzghoul, Ahmad; Alhalaweh, Amjad; Mahlin, Denny; Bergström, Christel A. S.

Part of JOURNAL OF CHEMICAL INFORMATION AND MODELING, p. 3396-3403, 2014.

DOI for Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pedersen, Christian; Slepenkin, Anatoly; Andersson, Sara B. E.; Fagerberg, Jonas H. et al.

Part of PLOS ONE, p. e110918-, 2014.

DOI for Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis Download full text (pdf) of Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna et al.

Part of Journal of Medicinal Chemistry, p. 6393-6402, 2014.

DOI for Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Alhalaweh, Amjad; Alzghoul, Ahmad; Kaialy, Waseem; Mahlin, Denny et al.

Part of Molecular Pharmaceutics, p. 3123-3132, 2014.

DOI for Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014.

DOI for Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Is the full potential of the biopharmaceutics classification system reached?

Bergström, Christel A. S.; Andersson, Sara B. E.; Fagerberg, Jonas H.; Ragnarsson, Gert et al.

Part of European Journal of Pharmaceutical Sciences, p. 224-231, 2014.

DOI for Is the full potential of the biopharmaceutics classification system reached?

Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Fagerberg, Jonas H.; Karlsson, Eva; Ulander, Johan; Hanisch, Gunilla et al.

Part of Pharmaceutical research, p. 578-589, 2015.

DOI for Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid Download full text (pdf) of Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 12-20, 2015.

DOI for Concomitant intake of alcohol may increase the absorption of poorly soluble drugs Download full text (pdf) of Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Persson, Linda C.; Porter, Christopher J. H.; Charman, William N.; Bergström, Christel A. S.

Part of Pharmaceutical research, p. 3225-3237, 2013.

DOI for Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Download full text (pdf) of Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Warren, Dallas B.; Bergström, Christel A. S.; Benameur, Hassan; Porter, Christopher J. H. et al.

Part of Molecular Pharmaceutics, p. 2823-2848, 2013.

DOI for Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Part of Toxicological Sciences, p. 328-343, 2013.

DOI for Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Download full text (pdf) of Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Early drug development predictions of glass-forming ability and physical stability of drugs

Mahlin, Denny; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 323-332, 2013.

DOI for Early drug development predictions of glass-forming ability and physical stability of drugs Download full text (pdf) of Early drug development predictions of glass-forming ability and physical stability of drugs

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013.

DOI for Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Bergstrom, Christel A. S.; Charman, Susan A.; Nicolazzo, Joseph A.

Part of Pharmaceutical research, p. 3131-3142, 2012.

DOI for Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Fagerberg, Jonas H.; Al-Tikriti, Yassir; Ragnarsson, Gert; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 1942-1952, 2012.

DOI for Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011.

DOI for Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Mahlin, Denny; Ponnambalam, Sopana; Hockerfelt, Mina Heidarian; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 498-506, 2011.

DOI for Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010.

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H.; Tsinman, Oksana; Sun, Na; Tsinman, Konstantin et al.

Part of Molecular pharmaceutics, p. 1419-1430, 2010.

DOI for Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Part of Molecular pharmaceutics, p. 1478-1487, 2010.

DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.

DOI for Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Part of Pharmaceutical research, p. 1816-1831, 2009.

DOI for Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012.

DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Prediction of ADMET Properties

Norinder, Ulf; Bergström, Christel

Part of ChemMedChem, p. 920-937, 2006.

DOI for Prediction of ADMET Properties

Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Bergström, Christel

Part of Expert opinion on drug metabolism & toxicology, p. 613-627, 2005.

DOI for Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Part of Clinical Pharmacokinetics, p. 877-899, 2002.

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008.

DOI for Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008.

DOI for Molecular characteristics for solid-state limited solubility

Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Aziz, Emad F; Gråsjö, Johan; Forsberg, Johan; Andersson, Egil et al.

Part of Journal of Physical Chemistry A, p. 9662-9669, 2007.

DOI for Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008.

DOI for Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007.

DOI for A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Poorly soluble marketed drugs display solvation limited solubility

Bergström, Christel; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina

Part of Journal of Medicinal Chemistry, p. 5858-5862, 2007.

DOI for Poorly soluble marketed drugs display solvation limited solubility

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Part of J Electr Spectr, p. 283-285, 2005.

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Part of Eur J Pharm Sci, p. 294-305, 2006.

Prediction of ADMET Properties.

Norinder, U; Bergström, C

Part of ChemMedChem, p. 920-937, 2006.