- Are you interested in a summer research project?
- Alexandra Teleki awarded ERC Consolidator Grant
- PhD-student position for project regarding importance of diffusion, dissolution and release mechanisms for dosage forms delivering drugs to the colonic environment
- Continued funding for project “Personalized medications for children suffering from severe diseases”
- Project grant for development of pedagogical online learning awarded to Per Larsson
Larsson, Per; Kabedev, Aleksei; Hossain, Md Shakhawath; Hubert, Madlen
Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation
Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J.; Camara, Miguel; Bergström, Christel
Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions
Bergström, Christel; Llinas, Antonio
Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds
We have a strong interest in understanding the molecular reasons resulting in a poor aqueous solubility and have established tools for computational pharmaceutics that guide the formulation scientists in successful development pathways for a particular compound. We are currently developing a virtual intestine to enable evaluation optimization of new dosage forms in the computer rather than making use of lengthy experiments or animal studies.
Our research in the field of poorly soluble compounds is extensively based on drug dissolution & permeation studies to predict e.g. intestinal solubility. The research team also focuses on the development of sophisticated dosage forms that transforms problematic compounds (poorly soluble, biologics) into well-functioning oral medications.
Enabling formulations making use of lipid-based formulations, amorphous materials, mesoporous carriers and functionalized drug carriers are currently being explored. Additive manufacturing and 3D printing to produce personalized medicines to improve treatment and quality of life of severely sick children is one of our main targets.