- 2023 Pharmaceutical Profiling Symposium full program and registration link
- PhD position in Molecular Pharmaceutics
- Registration is now open for the 12th Uppsala University Symposium on Pharmaceutical Profiling in Drug Discovery and Development
- Madlen Hubert becomes newly promoted Associate Professor!
Johannesson, Jenny; Wu, Mingjun; Johansson, Mathias; Bergström, Christel
Quality attributes for printable emulsion gels and 3D-printed tablets: Towards production of personalized dosage forms
Andreadis, Ioannis I.; Schulzen, Arne; Quodbach, Julian; Bergström, Christel
Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations
Johannesson, Jenny; Pathare, Malhar Manik; Johansson, Mathias; Bergström, Christel; Teleki, Alexandra
Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms
We have a strong interest in understanding the molecular reasons resulting in a poor aqueous solubility and have established tools for computational pharmaceutics that guide the formulation scientists in successful development pathways for a particular compound. We are currently developing a virtual intestine to enable evaluation optimization of new dosage forms in the computer rather than making use of lengthy experiments or animal studies.
Our research in the field of poorly soluble compounds is extensively based on drug dissolution & permeation studies to predict e.g. intestinal solubility. The research team also focuses on the development of sophisticated dosage forms that transforms problematic compounds (poorly soluble, biologics) into well-functioning oral medications.
Enabling formulations making use of lipid-based formulations, amorphous materials, mesoporous carriers and functionalized drug carriers are currently being explored. Additive manufacturing and 3D printing to produce personalized medicines to improve treatment and quality of life of severely sick children is one of our main targets.