All publications from Artursson

Epithelial and microbial determinants of colonic drug distribution

Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per

Part of European Journal of Pharmaceutical Sciences, 2023.

DOI for Epithelial and microbial determinants of colonic drug distribution Download full text (pdf) of Epithelial and microbial determinants of colonic drug distribution

Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

Lundquist, Patrik; Khodus, Georgiy; Niu, Zhigao; Thwala, Lungile Nomcebo et al.

Part of ACS Nano, 2022.

DOI for Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat Download full text 1 (pdf) of Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat Download full text 2 (pdf) of Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene et al.

Part of European Journal of Clinical Pharmacology, p. 1289-1299, 2022.

DOI for Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range Download full text (pdf) of Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Wegler, Christine; Wiśniewski, Jacek R; Robertsen, Ida; Christensen, Hege et al.

Part of Clinical Pharmacology and Therapeutics, p. 1142-1154, 2022.

DOI for Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity Download full text (pdf) of Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

Tremmel, Roman; Nies, Anne T.; van Eijck, Barbara A. C.; Handin, Niklas et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation Download full text (pdf) of Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Chen, Eugene C.; Matsson, Pär; Azimi, Mina; Zhou, Xujia et al.

Part of Pharmaceutical research, p. 1599-1613, 2022.

DOI for High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 Download full text (pdf) of High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Kvitne, Kine Eide; Asberg, Anders; Johnson, Line K.; Wegler, Christine et al.

Part of Clinical and Translational Science, p. 2685-2696, 2022.

DOI for Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity Download full text (pdf) of Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko et al.

Part of Biomedicine and Pharmacotherapy, 2022.

DOI for Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration Download full text (pdf) of Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration

Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Part of Pharmaceutical research, p. 1283-1289, 2022.

DOI for Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin et al.

Part of British Journal of Clinical Pharmacology, p. 4121-4133, 2022.

DOI for Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity Download full text (pdf) of Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity

Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial

Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege et al.

Part of Clinical and Translational Science, p. 221-233, 2022.

DOI for Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial Download full text (pdf) of Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial

The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

de Waal, Tom; Handin, Niklas; Brouwers, Joachim; Ferrante, Marc et al.

Part of International Journal of Pharmaceutics, 2022.

DOI for The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P. et al.

Part of Journal of Experimental & Clinical Cancer Research, 2021.

DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis Download full text (pdf) of Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Part of iScience, 2021.

DOI for Conditions for maintenance of hepatocyte differentiation and function in 3D cultures Download full text (pdf) of Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah et al.

Part of Advanced Drug Delivery Reviews, p. 289-331, 2021.

DOI for Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network Download full text (pdf) of Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Part of Journal of Pharmaceutical Sciences, p. 388-396, 2021.

DOI for Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1 Download full text (pdf) of Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Getting a grip with kirigami

Teleki, Alexandra; Artursson, Per

Part of Nature Materials, p. 1043-1044, 2021.

DOI for Getting a grip with kirigami

Hepatocyte size fractionation allows dissection of human liver zonation

Ölander, Magnus; Wegler, Christine; Flörkemeier, Inken; Treyer, Andrea et al.

Part of Journal of Cellular Physiology, p. 5885-5894, 2021.

DOI for Hepatocyte size fractionation allows dissection of human liver zonation Download full text (pdf) of Hepatocyte size fractionation allows dissection of human liver zonation

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef et al.

Part of Molecular Pharmaceutics, p. 1792-1805, 2021.

DOI for Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes Download full text (pdf) of Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Monitoring Drug-Target Interactions through Target Engagement-Mediated Amplification on Arrays and in situ

Al-Amin, Rasel A.; Johansson, Lars; Abdurakhmanov, Eldar; Landegren, Nils et al.

2021.

Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Flörkemeier, Inken; Steinhauer, Tamara N.; Hedemann, Nina; Ölander, Magnus et al.

Part of THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021.

DOI for Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer Download full text (pdf) of Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021.

DOI for Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease Download full text (pdf) of Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida et al.

Part of Clinical Pharmacology and Therapeutics, p. 762-771, 2021.

DOI for Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight Download full text (pdf) of Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

Part of Drug Metabolism And Disposition, p. 8-17, 2020.

DOI for A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

A new opening for orally taken peptide drugs

Artursson, Per; Lundquist, Patrik

Part of Nature Biomedical Engineering, p. 12-13, 2020.

DOI for A new opening for orally taken peptide drugs

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Part of Pharmaceutics, 2020.

DOI for Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions Download full text (pdf) of Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Cell-type-resolved proteomic analysis of the human liver

Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per

Part of Liver international (Print), p. 1770-1780, 2020.

DOI for Cell-type-resolved proteomic analysis of the human liver Download full text (pdf) of Cell-type-resolved proteomic analysis of the human liver

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

Part of Nature Communications, 2020.

DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy Download full text (pdf) of Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Global variability analysis of mRNA and protein concentrations across and within human tissues

Wegler, Christine; Ölander, Magnus; Wiśniewski, Jacek R; Lundquist, Patrik et al.

Part of NAR Genomics and Bioinformatics, 2020.

DOI for Global variability analysis of mRNA and protein concentrations across and within human tissues Download full text (pdf) of Global variability analysis of mRNA and protein concentrations across and within human tissues

Proteomic analysis of major cell types in the human liver

Ölander, Magnus; Wiśniewski, Jacek R.; Artursson, Per

Part of Liver international (Print), p. 1770-1780, 2020.

DOI for Proteomic analysis of major cell types in the human liver Download full text (pdf) of Proteomic analysis of major cell types in the human liver

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

Part of ChemMedChem, p. 1862-1874, 2020.

DOI for The Critical Role of Passive Permeability in Designing Successful Drugs

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

Part of Pharmaceutical research, 2019.

DOI for A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell)) Download full text (pdf) of A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

Part of Archives of Toxicology, p. 819-829, 2019.

DOI for A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes Download full text (pdf) of A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S8-S8, 2019.

DOI for Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Experimental approaches to understand intracellular based drug bioavailability

Artursson, Per

Part of Drug Metabolism and Pharmacokinetics, p. S3-S3, 2019.

DOI for Experimental approaches to understand intracellular based drug bioavailability

Image-based quantification of cell debris as a measure of apoptosis

Ölander, Magnus; Handin, Niklas; Artursson, Per

Part of Analytical Chemistry, p. 5548-5552, 2019.

DOI for Image-based quantification of cell debris as a measure of apoptosis Download full text (pdf) of Image-based quantification of cell debris as a measure of apoptosis

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

Part of AAPS Journal, 2019.

DOI for Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies Download full text (pdf) of Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

Part of Scientific Reports, 2019.

DOI for Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations Download full text (pdf) of Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Part of Journal of Proteome Research, p. 217-224, 2019.

DOI for Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking Download full text (pdf) of Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019.

DOI for Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Part of Scientific Reports, 2018.

DOI for Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound Download full text (pdf) of Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Part of Drug Metabolism And Disposition, p. 1776-1786, 2018.

DOI for CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiss, Frederik; Hammer, Helen S.; Klein, Kathrin; Planatscher, Hannes et al.

Part of Drug Metabolism And Disposition, p. 387-396, 2018.

DOI for Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates Download full text (pdf) of Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Treyer, Andrea; Mateus, André; Wisniewski, Jacek R.; Boriss, Hinnerk et al.

Part of Molecular Pharmaceutics, p. 2224-2233, 2018.

DOI for Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids Download full text (pdf) of Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Part of Genome Medicine, 2018.

DOI for Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Visnes, Torkild; Cazares-Korner, Armando; Hao, Wenjing; Wallner, Olov et al.

Part of Science, p. 834-839, 2018.

DOI for Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

Shrestha, Neha; Bouttefeux, Oriane; Vanvarenberg, Kevin; Lundquist, Patrik et al.

Part of Nanoscale, p. 603-613, 2018.

DOI for The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren, Maria; Simoff, Ivailo; Backlund, Maria; Wegler, Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 2909-2913, 2017.

DOI for A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Beloqui, Ana; Brayden, David J.; Artursson, Per; Preat, Veronique et al.

Part of Nature Protocols, p. 1387-1399, 2017.

DOI for A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Wiita, Elisee; Almlof, Ingrid et al.

Part of Journal of Medicinal Chemistry, p. 2148-2154, 2017.

DOI for Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Mateus, André; Treyer, Andrea; Wegler, Christine; Karlgren, Maria et al.

Part of Scientific Reports, p. 1-12, 2017.

DOI for Intracellular drug bioavailability: a new predictor of system dependent drug disposition Download full text (pdf) of Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Llona-Minguez, Sabin; Höglund, Andreas; Ghassemian, Artin; Desroses, Matthieu et al.

Part of Journal of Medicinal Chemistry, p. 4279-4292, 2017.

DOI for Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Mateus, André; Gordon, Laurie J.; Wayne, Gareth J.; Almqvist, Helena et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E6231-E6239, 2017.

DOI for Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

Kusuhara, Hiroyuki; Obach, R. Scott; Rostami-Hodjegan, Amin; Pang, K. Sandy et al.

Part of Journal of Pharmaceutical Sciences, p. 2188-2194, 2017.

DOI for Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines

Llona-Minguez, Sabin; Ghassemian, Artin; Baranczewski, Pawel; Desroses, Matthieu et al.

Part of MedChemComm, p. 1553-1560, 2017.

DOI for Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines

Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Pedersen, Jenny M.; Khan, Elin K.; Bergström, Christel; Palm, Johan et al.

Part of European Journal of Pharmaceutical Sciences, p. 70-76, 2017.

DOI for Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewsk, Jacek R. et al.

Part of Molecular Pharmaceutics, p. 3142-3151, 2017.

DOI for Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes Download full text (pdf) of Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Schowen, Katharine Barbara; Schowen, Richard L.; Borchardt, Susan E.; Borchardt, Paul M. et al.

Part of Journal of Pharmaceutical Sciences, p. 370-385, 2016.

DOI for A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Part of ACS Chemical Neuroscience, p. 1383-1392, 2016.

DOI for Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Almqvist, Helena; Axelsson, Hanna; Jafari, Rozbeh; Dan, Chen et al.

Part of Nature Communications, 2016.

DOI for CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil Download full text (pdf) of CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance

Vildhede, Anna; Wisniewski, Jacek; Norén, Agneta; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 96-96, 2016.

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 1017-1021, 2016.

DOI for Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Development of MS- based immunoassays for Cytochrome P450 and transporter quantification

Hammer, H. S.; Poetz, O.; Artursson, Per; Wegler, Christine

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S47-S47, 2016.

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Gordon, Laurie J; Allen, Morven; Artursson, Per; Hann, Michael M. et al.

Part of Journal of Biomolecular Screening, p. 156-164, 2016.

DOI for Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Jacques, Sylvain A.; Johanson, Lars et al.

Part of Journal of Medicinal Chemistry, p. 1140-1148, 2016.

DOI for Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Urdzik, Jozef; Vildhede, Anna; Wiśniewski, Jacek R.; Duraj, Frans et al.

Part of PROTEOMES, 2016.

DOI for Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases Download full text (pdf) of Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Impact of drug transporters on intracellular unbound drug concentrations

Mateus, André; Treyer, Andrea; Matsson, Par; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 147-147, 2016.

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

Wisniewski, Jacek R.; Vildhede, Anna; Norén, Agneta; Artursson, Per

Part of Journal of Proteomics, p. 234-247, 2016.

DOI for In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes Download full text (pdf) of In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug metabolism reviews (Softcover ed.), p. 56-57, 2016.

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug Metabolism And Disposition, p. 505-516, 2016.

DOI for Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

New cell-based approaches for better predictions of drug transport and cellular drug exposure

Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 7-7, 2016.

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Lundquist, Patrik; Artursson, Per

Part of Advanced Drug Delivery Reviews, p. 256-276, 2016.

DOI for Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues Download full text (pdf) of Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewski, Jacek R. et al.

Part of Drug metabolism reviews (Softcover ed.), p. 98-98, 2016.

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn; Matsson, Pär; Tyrchan, Christian; Artursson, Per et al.

Part of Nature Chemical Biology, p. 1065-+, 2016.

DOI for Structural and conformational determinants of macrocycle cell permeability

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Part of Analytical Biochemistry, p. 82-88, 2016.

DOI for Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions Download full text (pdf) of Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

The Need for Speed-Kinetic Limits of Drug Transporters

Matsson, Pär X.; Lundquist, Patrik; Artursson, Per

Part of TIPS - Trends in Pharmacological Sciences, p. 243-245, 2016.

DOI for The Need for Speed-Kinetic Limits of Drug Transporters

The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

Miyake, Masateru; Ragnarsson, Eva; Nakai, Daisuke; Artursson, Per

Part of Journal of Pharmaceutical Sciences, p. 2099-2104, 2016.

DOI for The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Ölander, Magnus; Wiśniewski, Jacek R.; Matsson, Pär; Lundquist, Patrik et al.

Part of Journal of Pharmaceutical Sciences, p. 817-827, 2016.

DOI for The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Good, James A. D.; Silver, Jim; Nunez-Otero, Carlos; Bahnan, Wael et al.

Part of Journal of Medicinal Chemistry, p. 2094-2108, 2016.

DOI for Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

To attach or not to attach: factors behind variable adhesion properties of cryopreserved human hepatocytes

Ölander, Magnus; Wisniewski, Jacek; Norén, Agneta; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 103-103, 2016.

Validation and development of MTH1 inhibitors for treatment of cancer

Berglund, U. Warpman; Sanjiv, K.; Gad, H.; Kalderen, C. et al.

Part of Annals of Oncology, p. 2275-2283, 2016.

DOI for Validation and development of MTH1 inhibitors for treatment of cancer Download full text (pdf) of Validation and development of MTH1 inhibitors for treatment of cancer

Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Matsson, Pär; Fenu, Luca A.; Lundquist, Patrik; Wisniewski, Jacek R. et al.

Part of TIPS - Trends in Pharmacological Sciences, p. 559-559, 2015.

DOI for Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Breaking the intestinal barrier to deliver drugs

Artursson, Per; Knight, Stefan

Part of Science, p. 716-717, 2015.

DOI for Breaking the intestinal barrier to deliver drugs

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Vildhede, Anna; Wisniewski, Jacek R.; Noren, Agneta; Karlgren, Maria et al.

Part of Journal of Proteome Research, p. 3305-3314, 2015.

DOI for Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance

Karlgren, Maria; Vildhede, Anna; Ölander, Magnus; Wisniewski, Jacek et al.

Part of Drug metabolism reviews (Softcover ed.), p. 245-246, 2015.

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Part of ChemMedChem, p. 455-460, 2015.

DOI for Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Quantifying the impact of transporters on cellular drug permeability.

Matsson, Pär; Fenu, Luca A; Lundquist, Patrik; Wiśniewski, Jacek R et al.

Part of TIPS - Trends in Pharmacological Sciences, p. 255-262, 2015.

DOI for Quantifying the impact of transporters on cellular drug permeability. Download full text (pdf) of Quantifying the impact of transporters on cellular drug permeability.

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene et al.

Part of European Journal of Medicinal Chemistry, p. 191-209, 2015.

DOI for Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Mateus, André; Matsson, Pär; Artursson, Per

Part of Journal of Medicinal Chemistry, p. 3005-3010, 2014.

DOI for A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014.

DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014.

DOI for Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014.

DOI for Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede, Anna; Karlgren, Maria; Svedberg, Elin K.; Wisniewski, Jacek R. et al.

Part of Drug Metabolism And Disposition, p. 1210-1218, 2014.

DOI for Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014.

DOI for Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge; Koolmeister, Tobias; Jemth, Ann-Sofie; Eshtad, Saeed et al.

Part of Nature, p. 215-221, 2014.

DOI for MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.

DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis; Artursson, Per; Avdeef, Alex; Di, Li et al.

Part of Molecular Pharmaceutics, p. 1727-1738, 2014.

DOI for Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.

DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Part of Cell, p. 313-328, 2014.

DOI for Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve, Etienne P. A.; Artursson, Per; Ingelman-Sundberg, Magnus; Karlgren, Maria

Part of Molecular Pharmaceutics, p. 3152-3163, 2013.

DOI for An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Ohrvik, Helena; Tydén, Eva; Artursson, Per; Oskarsson, Agneta et al.

Part of ISRN Toxicology, 2013.

DOI for Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Part of Molecular Pharmaceutics, p. 4252-4262, 2013.

DOI for Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Computational Prospecting for Drug-Transporter Interactions

Matsson, Pär; Artursson, Per

Part of Clinical Pharmacology and Therapeutics, p. 30-32, 2013.

DOI for Computational Prospecting for Drug-Transporter Interactions

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013.

DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Part of Toxicological Sciences, p. 328-343, 2013.

DOI for Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Download full text (pdf) of Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

In vitro characterization of interactions with drug transporting proteins

Artursson, Per; Matsson, Pär; Karlgren, Maria

Part of Transporters in Drug Development , p. 37-65, 2013.

DOI for In vitro characterization of interactions with drug transporting proteins

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013.

DOI for Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Johansson, Carl-Christer; Gennemark, Peter; Artursson, Per; Abelo, Angela et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 117-128, 2013.

DOI for Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Rapid Measurement of Intracellular Unbound Drug Concentrations

Mateus, André; Matsson, Pär; Artursson, Per

Part of Molecular Pharmaceutics, p. 2467-2478, 2013.

DOI for Rapid Measurement of Intracellular Unbound Drug Concentrations

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B. et al.

Part of Toxicology in Vitro, p. 1357-1376, 2013.

DOI for The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Caco-2 monolayers in experimental and theoretical predictions of drug transport

Artursson, Per; Palm, Katrin; Luthman, Kristina

Part of Advanced Drug Delivery Reviews, p. 280-289, 2012.

DOI for Caco-2 monolayers in experimental and theoretical predictions of drug transport

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Karlgren, Maria; Vildhede, Anna; Norinder, Ulf; Wisniewski, Jacek R. et al.

Part of Journal of Medicinal Chemistry, p. 4740-4763, 2012.

DOI for Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F. et al.

Part of Drug Discovery Today, p. 905-912, 2012.

DOI for Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012.

DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

mRNA expression of drug-transporting proteins along the human intestine and comparison with expression in Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Lazorova, Lucia et al.

2012.

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions

Ahlin, Gustav; Chen, L; Lazorova, Lucia; Chen, Ying et al.

Part of The Pharmacogenomics Journal, p. 400-411, 2011.

DOI for Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011.

DOI for Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Part of Molecular pharmaceutics, p. 1478-1487, 2010.

DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex et al.

Part of Nature reviews. Drug discovery, p. 597-614, 2010.

DOI for Coexistence of passive and carrier-mediated processes in drug transport

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Bose, Partha Pratim; Chatterjee, Urmimala; Hubatsch, Ina; Artursson, Per et al.

Part of Bioorganic & Medicinal Chemistry, p. 5896-5902, 2010.

DOI for In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010.

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010.

Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Strand, Sabina P; Lelu, Sylvie; Reitan, Nina K; de Lange Davies, Catharina et al.

Part of Biomaterials, p. 975-987, 2010.

DOI for Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Linnankoski, Johanna; Mäkelä, Johanna; Palmgren, Joni; Mauriala, Timo et al.

Part of Journal of Pharmaceutical Sciences, p. 2166-2175, 2010.

DOI for Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)

Karlgren, Maria; Ahlin, Gustav; Vildhede, Anna; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 305-306, 2010.

Uptake mechanism of ochratoxin A and citrinin through human liver

Gao, Ge; Karlgren, Maria; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 315-315, 2010.

Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Ahlin, Gustav; Hilgendorf, Constanze; Karlsson, Johan; Al-Khalili Szigyarto, Cristina et al.

Part of Drug Metabolism And Disposition, p. 2275-2283, 2009.

DOI for Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.

DOI for Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Part of Pharmaceutical research, p. 1816-1831, 2009.

DOI for Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Hayeshi, Rose; Hilgendorf, Constanze; Artursson, Per; Augustijns, Patrick et al.

Part of European Journal of Pharmaceutical Sciences, p. 383-396, 2008.

DOI for Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008.

DOI for Molecular characteristics for solid-state limited solubility

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008.

DOI for Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008.

DOI for Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Strand, Sabina P; Issa, Mohamed M; Christensen, Bjørn E; Vårum, Kjell M et al.

Part of Biomacromolecules, p. 3268-76, 2008.

DOI for Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

Ragnarsson, Eva G E; Schoultz, Ida; Gullberg, Elisabet; Carlsson, Anders H et al.

Part of Laboratory investigation; a journal of technical methods and pathology, p. 1215-26, 2008.

DOI for Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007.

DOI for A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers

Neuhoff, Sibylle; Artursson, Per; Ungell, Anna-Lena

Part of Journal of drug delivery science and technology, p. 259-266, 2007.

Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Hubatsch, Ina; Arvidsson, Per I.; Seebach, Dieter; Luthman, Kristina et al.

Part of Journal of Medicinal Chemistry, p. 5238-5242, 2007.

DOI for Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per

Part of Nature Protocols, p. 2111-2119, 2007.

DOI for Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Englund, Gunilla; Jacobson, Annica; Rorsman, Fredrik; Artursson, Per et al.

Part of Inflammatory Bowel Diseases, p. 291-297, 2007.

DOI for Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Hilgendorf, Constanze; Ahlin, Gustav; Seithel, Annick; Artursson, Per et al.

Part of Drug Metabolism And Disposition, p. 1333-1340, 2007.

DOI for Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Passive permeability and active transport models for the prediction of oral absorption

Artursson, P; Neuhoff, S; Tavelin, S; Matsson, P

Part of Comprehensive medicinal chemistry vol 5, p. 259-278, 2007.

Cell culture absorption models - state of the art

Artursson, P; Matsson, P

Part of Pharmacokinetic profiling in drug research, p. 71-, 2006.

Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.

Keita, Åsa V; Gullberg, Elisabet; Ericson, Ann-Charlott; Salim, Sa'ad Y et al.

Part of Lab Invest, p. 504-16, 2006.

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Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael et al.

Part of European Journal of Pharmaceutical Sciences, p. 295-305, 2006.

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Part of Eur J Pharm Sci, p. 294-305, 2006.

Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Regnström, Karin; Ragnarsson, Eva GE; Fryknäs, Mårten; Köping-Höggård, Magnus et al.

Part of Pharmaceutical research, p. 475-482, 2006.

DOI for Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Gullberg, Elisabet; Keita, Åsa V.; Salim, Sa'ad Y.; Andersson, Margaretha et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 632-639, 2006.

DOI for Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.

Neuhoff, Sibylle; Artursson, Per; Zamora, Ismael; Ungell, Anna-Lena

Part of Pharm Res, p. 350-9, 2006.

Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

Sai, Yoshimichi; Kaneko, Yosuke; Ito, Satsuki; Mitsuoka, Keisuke et al.

Part of Drug Metab Dispos, p. 1423-31, 2006.

Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Karlbom, Urban et al.

Part of European Journal of Pharmaceutical Sciences, p. 269-277, 2006.

DOI for Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

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Issa, M; Köping-Höggård, M; Tommeraas, K; Vårum, KM et al.

Part of Journal of controlled release, p. 103-112, 2006.

Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

Issa, Mohamed; Köping-Höggård, Magnus; Tammeraas, Kristoffer; Vårum, Kjell M. et al.

Part of Journal of Controlled Release, p. 103-112, 2006.

DOI for Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

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Köping-Höggård, M; Issa, M; Kohler, T; Tronde, A et al.

Part of Journal of gene medicine, p. 1215-1222, 2005.

A miniaturized nebulization catheter for improved gene delivery to the mouse lung.

Köping-Höggård, Magnus; Issa, Mohamed M; Köhler, Tamara; Tronde, Ann et al.

Part of J Gene Med, p. 1215-22, 2005.

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.

Avdeef, Alex; Artursson, Per; Neuhoff, Sibylle; Lazorova, Lucia et al.

Part of Eur J Pharm Sci, p. 333-49, 2005.

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Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Part of Analytical Chemistry, p. 5488-5493, 2005.

Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study

Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Part of Analytical Chemistry, p. 5488-5493, 2005.

null

Matsson, Pär; Bergström, Christel A. S.; Nagahara, Naoki; Tavelin, Staffan et al.

Part of Journal of Medicinal Chemistry, p. 604-613, 2005.

Exploring the role of different drug transport routes in permeability screening.

Matsson, Pär; Bergström, Christel A S; Nagahara, Naoki; Tavelin, Staffan et al.

Part of J Med Chem, p. 604-13, 2005.

Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.

Feith, G; Lindberg, S; Itoh, K; Okada, N et al.

Part of Int J Pharm, p. 127-, 2005.

null

des Rieux, Anne; Ragnarsson, Eva GE; Gullberg, Elisabet; Prerat, Veronique et al.

Part of European Journal of Pharmaceutical Sciences, p. 455-465, 2005.

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.

Yasar, U; Annas, A; Svensson, J-O; Lazorova, L et al.

Part of Xenobiotica, p. 785-96, 2005.

Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.

Hubatsch, Ina; Lazorova, Lucia; Vahlne, Anders; Artursson, Per

Part of Antimicrob Agents Chemother, p. 1087-92, 2005.

pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers

Neuhoff, Sibylle; Ungell, Anna-Lena; Zamora, Ismael; Artursson, Per

Part of European Journal of Pharmaceutical Sciences, p. 211-220, 2005.

DOI for pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers

Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.

des Rieux, Anne; Ragnarsson, Eva G E; Gullberg, Elisabet; Preat, Veronique et al.

Part of Eur J Pharm Sci, p. 455-65, 2005.

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Part of J Electr Spectr, p. 283-285, 2005.

Absorption Prediction

Artursson, Per; Matsson, Pär

Part of Profiling in Drug Discovery for Lead Selection, 2004.

Accuracy of calculated pH-dependent aqueous drug solubility.

Bergström, Christel A S; Luthman, Kristina; Artursson, Per

Part of Eur J Pharm Sci, p. 387-98, 2004.

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Englund, Gunilla; Hallberg, Pär; Artursson, Per; Michaëlsson, Karl et al.

Part of BMC Medicine, p. 2-8, 2004.

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Englund, Gunilla; Hallberg, Pär; Artursson, Per; Michaëlsson, Karl et al.

Part of BMC Medicine, p. 8-, 2004.

DOI for Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.

Nagahara, Naoki; Tavelin, Staffan; Artursson, Per

Part of J Pharm Sci, p. 2972-84, 2004.

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker ofMDR1-dependent drug efflux activity.

Taipalensuu, J; Tavelin, S; Lazorova, L; Svensson, AC et al.

Part of Eur J Pharm Sci, p. 69-, 2004.

null

Bergström, Christel A.S.; Wassvik, Carola M.; Norinder, Ulf; Luthman, Kristina et al.

Part of Journal of Chemical Information and Computer Sciences, p. 1477-1488, 2004.

Global and local computational models for aqueous solubility prediction of drug-like molecules.

Bergström, Christel A S; Wassvik, Carola M; Norinder, Ulf; Luthman, Kristina et al.

Part of J Chem Inf Comput Sci, p. 1477-88, 2004.

null

Köping-Höggård, M; Vårum, KM; Issa, M; Danielsen, S et al.

Part of Gene Therapy, p. 1441-1452, 2004.

Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.

Köping-Höggård, M; Vårum, K M; Issa, M; Danielsen, S et al.

Part of Gene Ther, p. 1441-52, 2004.

A new principle for tight junction modulation based on occludin peptides

Tavelin, Staffan; Hashimoto, Kei; Malkinson, J; Lazorova, Lucia et al.

Part of Molecular Pharmacology, p. 1530-1540, 2003.

DOI for A new principle for tight junction modulation based on occludin peptides

A New Principle for Tight Junction Modulation Based on Occludin Peptides

Tavelin, Staffan; Hashimoto, Kei; Lazorova, Lucia; Malkinson, John et al.

Part of Molecular Pharmacology, p. 1530-1540, 2003.

DOI for A New Principle for Tight Junction Modulation Based on Occludin Peptides

Absorption classification of oral drugs based on molecular surface properties

Bergström, Christel A S; Strafford, M; Lazorova, Lucia; Avdeef, A et al.

Part of Journal of Medicinal Chemistry, p. 558-570, 2003.

DOI for Absorption classification of oral drugs based on molecular surface properties

Absorption classification of oral drugs based on molecular surface properties

Bergström, Christel A. S.; Strafford, Melissa; Lazorova, Lucia; Avdeef, Alex et al.

Part of Journal of Medicinal Chemistry, p. 558-570, 2003.

DOI for Absorption classification of oral drugs based on molecular surface properties

An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport

Tavelin, Staffan; Taipalensuu, Jan; Hallböök, Finn; Vellonen, Kati-Sisko et al.

Part of Pharmaceutical research, p. 373-381, 2003.

DOI for An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport

An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes

Tavelin, Staffan; Taipalensuu, Jan; Hallböök, Finn; Vellonen, Kati-Sisko et al.

Part of Pharmaceutical research, p. 373-381, 2003.

DOI for An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes

Computational approaches to drug absorption and bioavailability. 17. Intestinal absorption; the role of polar surface area.

Artursson, P; Bergström, C A S

Part of Drug Bioavailability – Estimation of Solubility, Permeability, Absorption and Bioavailability, p. 341-, 2003.

Drug Bioavailability – Estimation of Solubility, Permeability, Absorption and Bioavailability

Van de Waterbeemd, H; Lennernas, H; Artursson, P

Wiley, 2003.

null

Engman, H; Tannergren, C; Artursson, P; Lennernäs, H

Part of European Journal of Pharmaceutical Sciences, p. 57-65, 2003.

null

Engman, Helena; Tannergren, Christer; Artursson, Per; Lennernäs, Hans

Part of European Journal of Pharmaceutical Sciences, p. 57-65, 2003.

Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamilin Caco-2 cell monolayers.

Engman, H; Tannergren, C; Artursson, P; Lennernas, H

Part of Eur J Pharm Sci, p. 57-, 2003.

Gene expression after vaccination of mice with formulations of diphtheria toxoid or tetanus toxoid and different adjuvants: identification of sharedand vaccine-specific genes in spleen lymphocytes.

Regnstrom, K; Ragnarsson, E; Artursson, P

Part of Vaccine, p. 2307-, 2003.

Genetic variation in the ATP-binding cassette transporter gene ABCG2(BCRP) in a Swedish population

Bäckström, Gunilla; Taipalensuu, Jan; Melhus, Håkan; Brändström, Helena et al.

Part of European Journal of Pharmaceutical Sciences, p. 359-364, 2003.

DOI for Genetic variation in the ATP-binding cassette transporter gene ABCG2(BCRP) in a Swedish population

null

Bergström, Christel A. S.; Norinder, Ulf; Luthman, Kristina; Artursson, Per

Part of Journal of Chemical Information and Computer Sciences, p. 1177-1185, 2003.

Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs.

Bergstrom, CA; Norinder, U; Luthman, K; Artursson, P

Part of J Chem Inf Comput Sci, p. 1177-, 2003.

null

K, Regnström; Ragnarsson, Eva GE; Köping-Höggård, Magnus; Torstensson, Elisabeth et al.

Part of Gene Therapy, p. 1575-83, 2003.

PEI - a potent, but not harmless, mucosal immuno-stimulator of mixed T-helper cell response and FasL-mediated cell death in mice

Regnstrom, K; Ragnarsson, EG; Koping-Hoggard, M; Torstensson, E et al.

Part of Gene Ther, p. 1575-, 2003.

null

Neuhoff, Sibylle; Ungell, Anna-Lena; Zamora, Ismael; Artursson, Per

Part of Pharmaceutical Research, p. 1141-1148, 2003.

pH-dependent bidirectional transport of weakly basic drugs across Caco-2monolayers: implications for drug-drug interactions.

Neuhoff, S; Ungell, AL; Zamora, I; Artursson, P

Part of Pharm Res, p. 1141-, 2003.

null

Tavelin, Staffan; Taipalensuu, Jan; Söderberg, Lauri; Morrison, Richard et al.

Part of Pharmaceutical Research, p. 397-405, 2003.

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers.

Tavelin, S; Taipalensuu, J; Soderberg, L; Morrison, R et al.

Part of Pharm Res, p. 397-, 2003.

null

Köping-Höggård, Magnus; Mel'nikova, Yulia S; Vårum, Kjell Mårten; Lindman, Björn et al.

Part of The Journal of Gene Medicine, p. 130-141, 2003.

Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo.

Koping-Hoggard, M; Mel'nikova, YS; Varum, KM; Lindman, B et al.

Part of J Gene Med, p. 130-, 2003.

Studies of membrane permeability and oral absorption 6: Caco-2 and emerging alternatives for prediction of intestinal drug transport: A general overview.

Artursson, P; Tavelin, S

Part of Drug Bioavailability - Estimation of Solubility, Permeability, Absorption and Bioavailability, p. 72-, 2003.

A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity

Raevsky, O.A.; Schaper, K.-J.; Artursson, P.; McFarland, J.W.

Part of Quant. Struct.- Act. Relat., p. 402-, 2002.

Applications of epithelial cell culture in studies of drug transport.

Tavelin, S; Grasjo, J; Taipalensuu, J; Ocklind, G et al.

Part of Methods Mol Biol, p. 233-, 2002.

Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues

Wong, AK; Ross, BP; Chan, YN; Artursson, Per et al.

Part of European Journal of Pharmaceutical Sciences, p. 113-118, 2002.

DOI for Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues

null

Bergström, Christel A. S.; Norinder, Ulf; Luthman, Kristina; Artursson, Per

Part of Pharmaceutical Research, p. 182-188, 2002.

Experimental and computational screening models for prediction of aqueous drug solubility.

Bergstrom, CA; Norinder, U; Luthman, K; Artursson, P

Part of Pharm Res, p. 182-, 2002.

Preparation and characterization of chitosans with oligosaccharide branches

Tömmeraas, C; Köping-Höggård, M; Vårum, KM; Christensen, BE et al.

Part of Carbohydr Res, p. 2455-, 2002.

Tetanus antigen modulates the gene expression profile of aluminium phosphate adjuvant in spleen lymphocytes in vivo.

Regnstrom, K; Ragnarsson, EG; Rydell, N; Sjoholm, I et al.

Part of Pharmacogenomics J, p. 57-, 2002.

null

Regnström, Karin; Ragnarsson, Eva; Rydell, Niclas; Sjöholm, Ingvar et al.

Part of The Pharmacogenomics Journal, p. 57-64, 2002.

null

Regnström, Karin; Ragnarsson, Eva GE; Rydell, Niclas; Sjöholm, Ingvar et al.

Part of The Pharmacogenomics Journal, p. 57-64, 2002.

Theoretical predictions of drug absorption in drug discovery and development.

Stenberg, P; Bergstrom, CA; Luthman, K; Artursson, P

Part of Clin Pharmacokinet, p. 877-, 2002.

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Part of Clinical Pharmacokinetics, p. 877-899, 2002.

Caco-2 monolayers in experimental and theoretical predictions of drugtransport.

Artursson, P; Palm, K; Luthman, K

Part of Adv. Drug Deliv. Rev., p. 27-, 2001.

Chitosan as a nonviral gene delivery system: Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo

Köping-Höggård, Magnus; Tubulekas, Ioannis; Guan, Holly; Edwards, Katarina et al.

Part of Gene Therapy, p. 1108-1121, 2001.

Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo

Köping-Höggard, M; Tubulekas, I; Guan, H; Edwards, Katarina et al.

Part of Gene Therapy, p. 1108-1121, 2001.

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and inhuman intestinal epithelial Caco-2 cell monolayers

Taipalensuu, Jan; Törnblom, Hans; Lindberg, Greger; Einarsson, Curt et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 164-170, 2001.

null

Engman, Helena; Lennernäs, Hans; Taipalensuu, Jan; Otter, Charlotta et al.

Part of Journal of Pharmaceutical Sciences, p. 1736-1751, 2001.

CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell linessuitable for drug transport studies.

Engman, HA; Lennernas, H; Taipalensuu, J; Otter, C et al.

Part of J Pharm Sci, p. 1736-, 2001.

Experimental and computational screening models for the prediction of intestinal drug absorption.

Stenberg, P; Norinder, U; Luthman, K; Artursson, P

Part of J Med Chem, p. 1927-, 2001.

Transport of lipophilic drug molecules in a new mucus-secreting cellculture model based on HT29-MTX cells.

Behrens, I; Stenberg, P; Artursson, P; Kissel, T

Part of Pharm Res, p. 1138-, 2001.

A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids

Ghaderi, R; Artursson, P; Carlfors, J

Part of Eur. J. Pharm. Sci., p. 1-, 2000.

null

Gullberg, Elisabet; Leonard, Maurice; Karlsson, Johan; Hopkins, Ann M. et al.

Part of Biochemical Biophysical Research Communications, p. 808-813, 2000.

Expression of specific markers and particle transport in a new humanintestinal M-cell model.

Gullberg, E; Leonard, M; Karlsson, J; Hopkins, AM et al.

Part of Biochem Biophys Res Commun, p. 808-, 2000.

Virtual screening of intestinal drug permeability

Stenberg, P; Luthman, K; Artursson, P

Part of J CONTROLLED RELEASE, p. 231-, 2000.

A conditionally immortalized epithelial cell line for studies of intestinal drug transport

Tavelin, S; Milovic, V; Ocklind, G; Olsson, S et al.

Part of J PHARMACO EXP THERAPEUTICS, p. 1212-, 1999.

Chitosans as absorption enhancers of poorly absorbable drugs 3: Influence of mucus on absorption enhancement

Schipper, NGM; Varum, KM; Stenberg, P; Ocklind, G et al.

Part of Eur J Pharm Sci, p. 335-, 1999.

null

Tavelin, Staffan; Milovic, Vladan; Ocklind, Göran; Olsson, Susanne et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 1212–1221-, 1999.

Conditionally immortalized rat fetal epithelial cell line (2/4/A1): A new model for studying apoptosis in the gut?

Milovic, V; Wolter, F; Tavelin, S; Artursson, P et al.

Part of Gastroenterology, p. 3949-, 1999.

Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs

Palm, K; Luthman, K; Ros, J; Grasjo, J et al.

Part of J PHARMACO EXP THERAPEUTICS, p. 435-, 1999.

Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres

Sturesson, C; Artursson, P; Ghaderi, R; Johansen, K et al.

Part of J Controlled Release, p. 377-, 1999.

Encapsulation of rotavirus into poly(lactide-co-glydolide) microspheres

Sturesson, Cecilia; Artursson, Per; Ghaderi, Raouf; Johansen, Kari et al.

Part of Journal of Controlled Release, p. 377-389, 1999.

DOI for Encapsulation of rotavirus into poly(lactide-co-glydolide) microspheres

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers

Raeissi, SD; Hidalgo, IJ; Segura-Aguilar, J; Artursson, P

Part of Pharm Res, p. 625-, 1999.

Novel lipoamino acid- and liposaccharide-based system for peptide delivery: Application for oral administration of tumor-selective somatostatin analogues

Toth, I; Malkinson, JP; Flinn, NS; Drouillat, B et al.

Part of Journal of Medicinal Chemistry, p. 4010-1013, 1999.

DOI for Novel lipoamino acid- and liposaccharide-based system for peptide delivery: Application for oral administration of tumor-selective somatostatin analogues

Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux

Karlsson, J; Ungell, AL; Grasjo, J; Artursson, P

Part of Eur J Pharm Sci, p. 47-, 1999.

Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties.

Stenberg, P; Luthman, K; Artursson, P

Part of Pharm Res, p. 205-, 1999.

Prediction of the intestinal absorption of endothelin receptor antagonistsusing three theoretical methods of increasing complexity.

Stenberg, P; Luthman, K; Ellens, H; Lee, CP et al.

Part of Pharm Res, p. 1520-, 1999.

Preparation of biodegradable microparticles using solution-enhanced dispersion by supercritical fluids (SEDS)

Ghaderi, R; Artursson, P; Carlfors, J

Part of Pharm Res, p. 676-, 1999.

Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics

Norinder, U; Osterberg, T; Artursson, P

Part of Eur J Pharm Sci, p. 49-, 1999.

Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: Assessment of molecular weight dependence and demonstration of transport routes

Lindmark, T; Schipper, N; Lazorová, Lucia; de, Boer AG et al.

Part of Journal of drug targeting (Print), p. 215-223, 1998.

DOI for Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: Assessment of molecular weight dependence and demonstration of transport routes

Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells

Lindmark, T; Kimura, Y; Artursson, P

Part of J PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, p. 362-, 1998.

Conditionally immortalized intestinal epithelial cells - A new model for studying intestinal epithelial cell turnover

Milovic, V; Ocklind, G; Artursson, P

Part of Ann.NY Acad.Sci., p. 201-, 1998.

Evaluation of dynamic polar molecular surface area as predictor of drug absorption: Comparison with other computational and experimental predictors

Palm, K; Luthman, K; Ungell, AL; Strandlund, G et al.

Part of J MEDI CHEM, p. 5382-, 1998.

Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber

Soderholm, JD; Hedman, L; Artursson, P; Franzen, L et al.

Part of Acta Physiol. Scand., p. 47-, 1998.

Quantification and imaging of mannitol transport through Caco-2 cell monolayers using a positron-emitting tracer

Lazorova, Lucia; Gråsjö, Johan; Artursson, Per; Bergström, Mats et al.

Part of Pharmaceutical research, p. 1141-1144, 1998.

DOI for Quantification and imaging of mannitol transport through Caco-2 cell monolayers using a positron-emitting tracer

The influence of intestinal mucus components on the diffusion of drugs

Larhed, AW; Artursson, P; Bjork, E

Part of PHARMACEUTICAL RESEARCH, p. 66-, 1998.

Transcellular delivery of peptide antigens across the intestinal epithelial barrier. In Peptide and protein drug research

Artursson, P; Lazorova, L

1998.

Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine

Raeissi, SD; Guo, ZY; Dobson, GL; Artursson, P et al.

Part of PHARMACEUTICAL RESEARCH, p. 1019-, 1997.

Diffusion of drugs in native and purified gastrointestinal mucus

Larhed, AW; Artursson, P; Grasjo, J; Bjork, E

Part of JOURNAL OF PHARMACEUTICAL SCIENCES, p. 660-, 1997.

Experimental and theoretical predictions of intestinal drug absorption, in Computer-assisted lead finding and optimization

Palm, K; Artursson, P; Luthman, K

Part of Verlag Helvetica Clinica Acta, 1997.

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

Artursson, P; Borchardt, RT

Part of PHARMACEUTICAL RESEARCH, p. 1655-, 1997.

Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate

Lindmark, T; Soderholm, JD; Olaison, G; Alvan, G et al.

Part of PHARMACEUTICAL RESEARCH, p. 930-, 1997.

Polar molecular surface properties predict the intestinal absorption of drugs in humans

Palm, K; Stenberg, P; Luthman, K; Artursson, P

Part of PHARMACEUTICAL RESEARCH, p. 568-, 1997.

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics

Norinder, U; Osterberg, T; Artursson, P

Part of PHARMACEUTICAL RESEARCH, p. 1786-, 1997.

Cell cultures to assess drug transport and metabolism - Preface

Hochman, JH; Artursson, P

Part of ADVANCED DRUG DELIVERY REVIEWS, p. 1-, 1996.

Chitosans as absorption enhancers for poorly absorbable drugs .1. Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells

Schipper, NGM; Varum, KM; Artursson, P

Part of PHARMACEUTICAL RESEARCH, p. 1686-, 1996.

Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo

Lennernas, H; Palm, K; Fagerholm, U; Artursson, P

Part of INTERNATIONAL JOURNAL OF PHARMACEUTICS, p. 103-, 1996.

Correlation of drug absorption with molecular surface properties

Palm, K; Luthman, K; Ungell, AL; Strandlund, G et al.

Part of JOURNAL OF PHARMACEUTICAL SCIENCES, p. 32-, 1996.

Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH)

Flinn, N; Hussain, I; Shaw, A; Artursson, P et al.

Part of INTERNATIONAL JOURNAL OF PHARMACEUTICS, p. 167-, 1996.

Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers.

Buur, A; Trier, L; Magnusson, C; Artursson, P

Part of INTERNATIONAL JOURNAL OF PHARMACEUTICS, p. 223-, 1996.

Studying transport in absorptive epithelia

Artursson, P; Karlsson, J; Ocklind, G; Schipper, N

Part of Cell models of epithelial tissues - A practical approach, p. 111-, 1996.

Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells

Lazorova, Lucia; Artursson, Per; Engström, Å; Sjölander, A

Part of American Journal of Physiology, p. G554-G564, 1996.

COCULTURES OF HUMAN INTESTINAL GOBLET (HT29-H) AND ABSORPTIVE (CACO-2) CELLS FOR STUDIES OF DRUG AND PEPTIDE ABSORPTION

WIKMAN LARHED, A; ARTURSSON, P

Part of EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, p. 171-, 1995.

MECHANISMS OF ABSORPTION ENHANCEMENT BY MEDIUM-CHAIN FATTY-ACIDS IN INTESTINAL EPITHELIAL CACO-2 CELL MONOLAYERS

LINDMARK, T; NIKKILA, T; ARTURSSON, P

Part of JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, p. 958-, 1995.

STARCH MICROSPHERES INDUCE PULSATILE DELIVERY OF DRUGS AND PEPTIDES ACROSS THE EPITHELIAL BARRIER BY REVERSIBLE SEPARATION OF THE TIGHT JUNCTIONS

BJORK, E; ISAKSSON, U; EDMAN, P; ARTURSSON, P

Part of JOURNAL OF DRUG TARGETING, p. 501-, 1995.

Microspheres as drug carriers

some consequences of the delivery of microparticles to the reticuloendothelial system Artursson, Per

A cell free approach for determination of cell specific drug binding based on phospholipid speciation

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

null

Köping-Höggård, Magnus; Vårum, Kjell Mårten; Issa, Mohamed; Danielsen, Signe et al.

Part of Gene Therapy

null

Bergström, Christel A. S.; Luthman, Kristina; Artursson, Per

Biliary Drug Excretion and Drug-drug Interactions in Sandwich Cultured Human Hepatocytes Predicted from Inverted Membrane Vesicles and Targeted Proteomics

Pedersen, Jenny M.; Svedberg, Elin; Lai, Yurong; Qui, Xi et al.

null

Issa, M; Strand, SP; Vårum, KM; Artursson, P

Comparative proteomics of human liver tissue and hepatocytes reveal systematic differences in proteins determining hepatic drug exposure

Vildhede, Anna; Wiśniewski, Jacek R.; Norén, Agneta; Karlgren, Maria et al.

null

Matsson, Pär; Pedersen, Jenny; Norinder, Ulf; Bergström, Christel A. S. et al.

Differential expression of ABC transporters in colonic and rectal mucosa during active and inactive phases of ulcerative colitis

Englund, Gunilla; Jacobson, Annica; Rorsman, Fredrik; Artursson, Per et al.

Discovery and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 1-7 Analogues

Fransson, Rebecca; Nordvall, Gunnar; Botros, Milad; Carlsson, Anna et al.

null

Engman, Helena; Svensson, Ann-Cathrin; Artursson, Per

Effect of cell penetrating peptides on GLP-1R-mediated intracellular delivery of antisense oligonucleotides

Treyer, Andrea; Viljanen, Johan; Dahlén, Anders; Meuller, Johan et al.

Effects of obesity and weight loss on global protein expression in human liver and jejunum

Wegler, Christine; Robertsen, Ida; Wisniewski, Jacek R; Hjelmesæth, Jøran et al.

null

Wassvik, Carola M.; Holmén, Anders G.; Artursson, Per

null

Bergström, Christel A. S.; Wassvik, Carola M.; Norinder, Ulf; Luthman, Kristina et al.

Global expression variability of proteins across and within human tissues

Wegler, Christine; Ölander, Magnus; Wisniewski, Jacek R; Lundquist, Patrik et al.

Impact of drug transporters on intracellular drug concentrations

Mateus, André; Treyer, Andrea; Karlgren, Maria; Matsson, Pär et al.

null

Neuhoff, Sibylle; Artursson, Per; Zamora, Ismael; Ungell, Anna-Lena

Impact of intracellular bioavailability on metabolic drug-drug interactions

Treyer, Andrea; Ullah, Mohammed; Neil, Parrott; Molitor, Birgit et al.

Impact of intracellular drug bioavailability on cellular drug response

Mateus, André; Gordon, Laurie J.; Wayne, Gareth J.; Almqvist, Helena et al.

null

Gullberg, Elisabet; Velin Keita, Åsa; Salim, Sa'ad; Andersson, Margaretha et al.

null

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