All publications from Artursson
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Epithelial and microbial determinants of colonic drug distribution
Part of European Journal of Pharmaceutical Sciences, 2023.
DOI for Epithelial and microbial determinants of colonic drug distribution Download full text (pdf) of Epithelial and microbial determinants of colonic drug distribution
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Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Part of Journal of Neuroscience, p. 2222-2241, 2023.
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Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
Part of ACS Nano, 2022.
DOI for Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat Download full text 1 (pdf) of Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat Download full text 2 (pdf) of Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
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Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
Part of European Journal of Clinical Pharmacology, p. 1289-1299, 2022.
DOI for Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range Download full text (pdf) of Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
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Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
Part of Clinical Pharmacology and Therapeutics, p. 1142-1154, 2022.
DOI for Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity Download full text (pdf) of Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
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Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
Part of International Journal of Molecular Sciences, 2022.
DOI for Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation Download full text (pdf) of Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
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High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
Part of Pharmaceutical research, p. 1599-1613, 2022.
DOI for High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 Download full text (pdf) of High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
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Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity
Part of Clinical and Translational Science, p. 2685-2696, 2022.
DOI for Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity Download full text (pdf) of Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity
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Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
Part of Biomedicine and Pharmacotherapy, 2022.
DOI for Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration Download full text (pdf) of Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
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Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
Part of Nucleic Acids Research, p. e129-e129, 2022.
DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
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Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics
Part of Pharmaceutical research, p. 1283-1289, 2022.
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Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
Part of British Journal of Clinical Pharmacology, p. 4121-4133, 2022.
DOI for Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity Download full text (pdf) of Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
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Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial
Part of Clinical and Translational Science, p. 221-233, 2022.
DOI for Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial Download full text (pdf) of Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial
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The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients
Part of International Journal of Pharmaceutics, 2022.
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Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
Part of Journal of Experimental & Clinical Cancer Research, 2021.
DOI for Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis Download full text (pdf) of Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
Part of iScience, 2021.
DOI for Conditions for maintenance of hepatocyte differentiation and function in 3D cultures Download full text (pdf) of Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Part of Advanced Drug Delivery Reviews, p. 289-331, 2021.
DOI for Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network Download full text (pdf) of Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
Part of Journal of Pharmaceutical Sciences, p. 388-396, 2021.
DOI for Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1 Download full text (pdf) of Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
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Getting a grip with kirigami
Part of Nature Materials, p. 1043-1044, 2021.
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Hepatocyte size fractionation allows dissection of human liver zonation
Part of Journal of Cellular Physiology, p. 5885-5894, 2021.
DOI for Hepatocyte size fractionation allows dissection of human liver zonation Download full text (pdf) of Hepatocyte size fractionation allows dissection of human liver zonation
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Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
Part of Molecular Pharmaceutics, p. 1792-1805, 2021.
DOI for Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes Download full text (pdf) of Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
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Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer
Part of THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2021.
DOI for Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer Download full text (pdf) of Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer
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Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021.
DOI for Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease Download full text (pdf) of Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
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Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight
Part of Clinical Pharmacology and Therapeutics, p. 762-771, 2021.
DOI for Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight Download full text (pdf) of Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight
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A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity
Part of Drug Metabolism And Disposition, p. 8-17, 2020.
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A new opening for orally taken peptide drugs
Part of Nature Biomedical Engineering, p. 12-13, 2020.
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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
Part of Pharmaceutics, 2020.
DOI for Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions Download full text (pdf) of Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
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Cell-type-resolved proteomic analysis of the human liver
Part of Liver international, p. 1770-1780, 2020.
DOI for Cell-type-resolved proteomic analysis of the human liver Download full text (pdf) of Cell-type-resolved proteomic analysis of the human liver
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
Part of Nature Communications, 2020.
DOI for Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy Download full text (pdf) of Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
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Global variability analysis of mRNA and protein concentrations across and within human tissues
Part of NAR Genomics and Bioinformatics, 2020.
DOI for Global variability analysis of mRNA and protein concentrations across and within human tissues Download full text (pdf) of Global variability analysis of mRNA and protein concentrations across and within human tissues
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The Critical Role of Passive Permeability in Designing Successful Drugs
Part of ChemMedChem, p. 1862-1874, 2020.
DOI for The Critical Role of Passive Permeability in Designing Successful Drugs
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A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
Part of Pharmaceutical research, 2019.
DOI for A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell)) Download full text (pdf) of A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
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A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
Part of Archives of Toxicology, p. 819-829, 2019.
DOI for A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes Download full text (pdf) of A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
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Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver
Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S8-S8, 2019.
DOI for Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver
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Experimental approaches to understand intracellular based drug bioavailability
Part of Drug Metabolism and Pharmacokinetics, p. S3-S3, 2019.
DOI for Experimental approaches to understand intracellular based drug bioavailability
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Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
Part of AAPS Journal, 2019.
DOI for Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies Download full text (pdf) of Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
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Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
Part of Scientific Reports, 2019.
DOI for Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations Download full text (pdf) of Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
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Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking
Part of Journal of Proteome Research, p. 217-224, 2019.
DOI for Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking Download full text (pdf) of Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking
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Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper
Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019.
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Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
Part of Scientific Reports, 2018.
DOI for Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound Download full text (pdf) of Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
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CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
Part of Drug Metabolism And Disposition, p. 1776-1786, 2018.
DOI for CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
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Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates
Part of Drug Metabolism And Disposition, p. 387-396, 2018.
DOI for Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates Download full text (pdf) of Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates
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Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
Part of Molecular Pharmaceutics, p. 2224-2233, 2018.
DOI for Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids Download full text (pdf) of Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
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A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
Part of Journal of Pharmaceutical Sciences, p. 2909-2913, 2017.
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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
Part of Journal of Medicinal Chemistry, p. 2148-2154, 2017.
DOI for Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
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Intracellular drug bioavailability: a new predictor of system dependent drug disposition
Part of Scientific Reports, p. 1-12, 2017.
DOI for Intracellular drug bioavailability: a new predictor of system dependent drug disposition Download full text (pdf) of Intracellular drug bioavailability: a new predictor of system dependent drug disposition
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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Part of Journal of Medicinal Chemistry, p. 4279-4292, 2017.
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Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery
Part of Proceedings of the National Academy of Sciences of the United States of America, p. E6231-E6239, 2017.
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Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist
Part of Journal of Pharmaceutical Sciences, p. 2188-2194, 2017.
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Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)
Part of European Journal of Pharmaceutical Sciences, p. 70-76, 2017.
DOI for Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)
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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes
Part of Molecular Pharmaceutics, p. 3142-3151, 2017.
DOI for Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes Download full text (pdf) of Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes
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A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man
Part of Journal of Pharmaceutical Sciences, p. 370-385, 2016.
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Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures
Part of ACS Chemical Neuroscience, p. 1383-1392, 2016.
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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Part of Nature Communications, 2016.
DOI for CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil Download full text (pdf) of CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
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Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance
Part of Drug metabolism reviews (Softcover ed.), p. 96-96, 2016.
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Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9
Part of Journal of Pharmaceutical Sciences, p. 1017-1021, 2016.
DOI for Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9
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Development of MS- based immunoassays for Cytochrome P450 and transporter quantification
Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S47-S47, 2016.
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Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability
Part of Journal of Biomolecular Screening, p. 156-164, 2016.
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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Part of Journal of Medicinal Chemistry, p. 1140-1148, 2016.
DOI for Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
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Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases
Part of PROTEOMES, 2016.
DOI for Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases Download full text (pdf) of Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases
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Impact of drug transporters on intracellular unbound drug concentrations
Part of Drug metabolism reviews (Softcover ed.), p. 147-147, 2016.
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In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes
Part of Journal of Proteomics, p. 234-247, 2016.
DOI for In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes Download full text (pdf) of In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes
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Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach
Part of Drug metabolism reviews (Softcover ed.), p. 56-57, 2016.
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Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach
Part of Drug Metabolism And Disposition, p. 505-516, 2016.
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New cell-based approaches for better predictions of drug transport and cellular drug exposure
Part of Drug metabolism reviews (Softcover ed.), p. 7-7, 2016.
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Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
Part of Advanced Drug Delivery Reviews, p. 256-276, 2016.
DOI for Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues Download full text (pdf) of Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
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Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison
Part of Drug metabolism reviews (Softcover ed.), p. 98-98, 2016.
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Structural and conformational determinants of macrocycle cell permeability
Part of Nature Chemical Biology, p. 1065-+, 2016.
DOI for Structural and conformational determinants of macrocycle cell permeability
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Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions
Part of Analytical Biochemistry, p. 82-88, 2016.
DOI for Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions Download full text (pdf) of Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions
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The Need for Speed-Kinetic Limits of Drug Transporters
Part of TIPS - Trends in Pharmacological Sciences, p. 243-245, 2016.
DOI for The Need for Speed-Kinetic Limits of Drug Transporters
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The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells
Part of Journal of Pharmaceutical Sciences, p. 2099-2104, 2016.
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The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition
Part of Journal of Pharmaceutical Sciences, p. 817-827, 2016.
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Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity
Part of Journal of Medicinal Chemistry, p. 2094-2108, 2016.
DOI for Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity
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To attach or not to attach: factors behind variable adhesion properties of cryopreserved human hepatocytes
Part of Drug metabolism reviews (Softcover ed.), p. 103-103, 2016.
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Addendum to 'Quantifying the impact of transporters on cellular drug permeability'
Part of TIPS - Trends in Pharmacological Sciences, p. 559-559, 2015.
DOI for Addendum to 'Quantifying the impact of transporters on cellular drug permeability'
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Breaking the intestinal barrier to deliver drugs
Part of Science, p. 716-717, 2015.
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Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure
Part of Journal of Proteome Research, p. 3305-3314, 2015.
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Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance
Part of Drug metabolism reviews (Softcover ed.), p. 245-246, 2015.
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Quantifying the impact of transporters on cellular drug permeability.
Part of TIPS - Trends in Pharmacological Sciences, p. 255-262, 2015.
DOI for Quantifying the impact of transporters on cellular drug permeability. Download full text (pdf) of Quantifying the impact of transporters on cellular drug permeability.
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Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo
Part of European Journal of Medicinal Chemistry, p. 191-209, 2015.
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A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
Part of Journal of Medicinal Chemistry, p. 3005-3010, 2014.
DOI for A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
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Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket
Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014.
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Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014.
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Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues
Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014.
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Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions
Part of Drug Metabolism And Disposition, p. 1210-1218, 2014.
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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties
Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014.
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Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.
DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
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Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition
Part of Molecular Pharmaceutics, p. 1727-1738, 2014.
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Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles
Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.
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An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux
Part of Molecular Pharmaceutics, p. 3152-3163, 2013.
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Computational Prospecting for Drug-Transporter Interactions
Part of Clinical Pharmacology and Therapeutics, p. 30-32, 2013.
DOI for Computational Prospecting for Drug-Transporter Interactions
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Constrained H-Phe-Phe-NH2 Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability
Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013.
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Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
Part of Toxicological Sciences, p. 328-343, 2013.
DOI for Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Download full text (pdf) of Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
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In vitro characterization of interactions with drug transporting proteins
Part of Transporters in Drug Development , p. 37-65, 2013.
DOI for In vitro characterization of interactions with drug transporting proteins
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Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice
Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013.
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Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat
Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 117-128, 2013.
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Rapid Measurement of Intracellular Unbound Drug Concentrations
Part of Molecular Pharmaceutics, p. 2467-2478, 2013.
DOI for Rapid Measurement of Intracellular Unbound Drug Concentrations
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The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox
Part of Toxicology in Vitro, p. 1357-1376, 2013.
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Caco-2 monolayers in experimental and theoretical predictions of drug transport
Part of Advanced Drug Delivery Reviews, p. 280-289, 2012.
DOI for Caco-2 monolayers in experimental and theoretical predictions of drug transport
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Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions
Part of Journal of Medicinal Chemistry, p. 4740-4763, 2012.
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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
Part of Drug Discovery Today, p. 905-912, 2012.
DOI for Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
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Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions
Part of The Pharmacogenomics Journal, p. 400-411, 2011.
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Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors
Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011.
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A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery
Part of Molecular pharmaceutics, p. 1478-1487, 2010.
DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery
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Coexistence of passive and carrier-mediated processes in drug transport
Part of Nature reviews. Drug discovery, p. 597-614, 2010.
DOI for Coexistence of passive and carrier-mediated processes in drug transport
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In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation
Part of Bioorganic & Medicinal Chemistry, p. 5896-5902, 2010.
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Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte
Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010.
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Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)
Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010.
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Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking
Part of Biomaterials, p. 975-987, 2010.
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Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models
Part of Journal of Pharmaceutical Sciences, p. 2166-2175, 2010.
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Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)
Part of Drug metabolism reviews (Softcover ed.), p. 305-306, 2010.
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Uptake mechanism of ochratoxin A and citrinin through human liver
Part of Drug metabolism reviews (Softcover ed.), p. 315-315, 2010.
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Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs
Part of Drug Metabolism And Disposition, p. 2275-2283, 2009.
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Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells
Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.
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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs
Part of Pharmaceutical research, p. 1816-1831, 2009.
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Part of European Journal of Pharmaceutical Sciences, p. 383-396, 2008.
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Molecular characteristics for solid-state limited solubility
Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008.
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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)
Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008.
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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008.
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Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties
Part of Biomacromolecules, p. 3268-76, 2008.
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Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis
Part of Laboratory investigation; a journal of technical methods and pathology, p. 1215-26, 2008.
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A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)
Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007.
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Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers
Part of Journal of drug delivery science and technology, p. 259-266, 2007.
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Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1
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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
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Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)
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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
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Passive permeability and active transport models for the prediction of oral absorption
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Cell culture absorption models - state of the art
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Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.
Part of Lab Invest, p. 504-16, 2006.
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null
Part of European Journal of Pharmaceutical Sciences, p. 295-305, 2006.
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Contribution of solid-state properties to the aqueous solubility of drugs.
Part of Eur J Pharm Sci, p. 294-305, 2006.
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Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery
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Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches
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Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.
Part of Pharm Res, p. 350-9, 2006.
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Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.
Part of Drug Metab Dispos, p. 1423-31, 2006.
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Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
Part of European Journal of Pharmaceutical Sciences, p. 269-277, 2006.
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null
Part of Journal of controlled release, p. 103-112, 2006.
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Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo
Part of Journal of Controlled Release, p. 103-112, 2006.
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null
Part of Journal of gene medicine, p. 1215-1222, 2005.
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A miniaturized nebulization catheter for improved gene delivery to the mouse lung.
Part of J Gene Med, p. 1215-22, 2005.
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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.
Part of Eur J Pharm Sci, p. 333-49, 2005.
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null
Part of Analytical Chemistry, p. 5488-5493, 2005.
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Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study
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null
Part of Journal of Medicinal Chemistry, p. 604-613, 2005.
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Exploring the role of different drug transport routes in permeability screening.
Part of J Med Chem, p. 604-13, 2005.
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Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.
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null
Part of European Journal of Pharmaceutical Sciences, p. 455-465, 2005.
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Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Part of Xenobiotica, p. 785-96, 2005.
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Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.
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pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers
Part of European Journal of Pharmaceutical Sciences, p. 211-220, 2005.
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Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.
Part of Eur J Pharm Sci, p. 455-65, 2005.
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X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.
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Absorption Prediction
Part of Profiling in Drug Discovery for Lead Selection, 2004.
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Accuracy of calculated pH-dependent aqueous drug solubility.
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Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
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Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.
Part of J Pharm Sci, p. 2972-84, 2004.
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null
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Global and local computational models for aqueous solubility prediction of drug-like molecules.
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null
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Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.
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A new principle for tight junction modulation based on occludin peptides
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A New Principle for Tight Junction Modulation Based on Occludin Peptides
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DOI for A New Principle for Tight Junction Modulation Based on Occludin Peptides
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Absorption classification of oral drugs based on molecular surface properties
Part of Journal of Medicinal Chemistry, p. 558-570, 2003.
DOI for Absorption classification of oral drugs based on molecular surface properties
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Absorption classification of oral drugs based on molecular surface properties
Part of Journal of Medicinal Chemistry, p. 558-570, 2003.
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An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes
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Computational approaches to drug absorption and bioavailability. 17. Intestinal absorption; the role of polar surface area.
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Part of European Journal of Pharmaceutical Sciences, p. 57-65, 2003.
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Part of European Journal of Pharmaceutical Sciences, p. 57-65, 2003.
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Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamilin Caco-2 cell monolayers.
Part of Eur J Pharm Sci, p. 57-, 2003.
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Genetic variation in the ATP-binding cassette transporter gene ABCG2(BCRP) in a Swedish population
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null
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Molecular Descriptors Influencing Melting Point and Their Role in Classification of Solid Drugs.
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null
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PEI - a potent, but not harmless, mucosal immuno-stimulator of mixed T-helper cell response and FasL-mediated cell death in mice
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pH-dependent bidirectional transport of weakly basic drugs across Caco-2monolayers: implications for drug-drug interactions.
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Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers.
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Part of The Journal of Gene Medicine, p. 130-141, 2003.
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Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo.
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Studies of membrane permeability and oral absorption 6: Caco-2 and emerging alternatives for prediction of intestinal drug transport: A general overview.
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A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity
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Applications of epithelial cell culture in studies of drug transport.
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Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues
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Experimental and computational screening models for prediction of aqueous drug solubility.
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Preparation and characterization of chitosans with oligosaccharide branches
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Tetanus antigen modulates the gene expression profile of aluminium phosphate adjuvant in spleen lymphocytes in vivo.
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Theoretical predictions of drug absorption in drug discovery and development.
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Theoretical predictions of drug absorption in drug discovery and development
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Caco-2 monolayers in experimental and theoretical predictions of drugtransport.
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Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and inhuman intestinal epithelial Caco-2 cell monolayers
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null
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CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell linessuitable for drug transport studies.
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Experimental and computational screening models for the prediction of intestinal drug absorption.
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Transport of lipophilic drug molecules in a new mucus-secreting cellculture model based on HT29-MTX cells.
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A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids
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Expression of specific markers and particle transport in a new humanintestinal M-cell model.
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Virtual screening of intestinal drug permeability
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A conditionally immortalized epithelial cell line for studies of intestinal drug transport
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Chitosans as absorption enhancers of poorly absorbable drugs 3: Influence of mucus on absorption enhancement
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null
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Conditionally immortalized rat fetal epithelial cell line (2/4/A1): A new model for studying apoptosis in the gut?
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Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs
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Encapsulation of rotavirus into poly(lactide-co-glycolide) microspheres
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Encapsulation of rotavirus into poly(lactide-co-glydolide) microspheres
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Novel lipoamino acid- and liposaccharide-based system for peptide delivery: Application for oral administration of tumor-selective somatostatin analogues
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Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux
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Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties.
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Prediction of the intestinal absorption of endothelin receptor antagonistsusing three theoretical methods of increasing complexity.
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Preparation of biodegradable microparticles using solution-enhanced dispersion by supercritical fluids (SEDS)
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Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics
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Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: Assessment of molecular weight dependence and demonstration of transport routes
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Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells
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Conditionally immortalized intestinal epithelial cells - A new model for studying intestinal epithelial cell turnover
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Evaluation of dynamic polar molecular surface area as predictor of drug absorption: Comparison with other computational and experimental predictors
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Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber
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The influence of intestinal mucus components on the diffusion of drugs
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Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine
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Diffusion of drugs in native and purified gastrointestinal mucus
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Experimental and theoretical predictions of intestinal drug absorption, in Computer-assisted lead finding and optimization
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Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
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Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate
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Polar molecular surface properties predict the intestinal absorption of drugs in humans
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Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics
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Cell cultures to assess drug transport and metabolism - Preface
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Chitosans as absorption enhancers for poorly absorbable drugs .1. Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells
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Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
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Correlation of drug absorption with molecular surface properties
Part of JOURNAL OF PHARMACEUTICAL SCIENCES, p. 32-, 1996.
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Oral absorption studies of lipid-polylysine conjugates of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH)
Part of INTERNATIONAL JOURNAL OF PHARMACEUTICS, p. 167-, 1996.
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Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers.
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Studying transport in absorptive epithelia
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Transport of an influenza virus vaccine formulation (iscom) in Caco-2 cells
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COCULTURES OF HUMAN INTESTINAL GOBLET (HT29-H) AND ABSORPTIVE (CACO-2) CELLS FOR STUDIES OF DRUG AND PEPTIDE ABSORPTION
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MECHANISMS OF ABSORPTION ENHANCEMENT BY MEDIUM-CHAIN FATTY-ACIDS IN INTESTINAL EPITHELIAL CACO-2 CELL MONOLAYERS
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STARCH MICROSPHERES INDUCE PULSATILE DELIVERY OF DRUGS AND PEPTIDES ACROSS THE EPITHELIAL BARRIER BY REVERSIBLE SEPARATION OF THE TIGHT JUNCTIONS
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Microspheres as drug carriers
some consequences of the delivery of microparticles to the reticuloendothelial system Artursson, Per
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null
Part of Gene Therapy