- PhD position in Molecular Pharmaceutics
- ***Update – Symposium will be held online***
- The registration for the upcoming 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022 is now open
- ***SAVE THE DATE*** 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022
Half-time seminar: Artificial colonic mucus development as in vitro drug diffusion testing platform
Half-time seminar: Drug delivery platform for optimal intestinal absorption of oral antibiotics
New Horizons in Drug Delivery and Formulations 2023
Half-time seminar: Influence of intra- and extracellular free drug concentrations in the human colon on local and systemic drug exposure
Hammar, Rebekkah; Sellin, Mikael E.; Artursson, Per
Epithelial and microbial determinants of colonic drug distribution
Lundquist, Patrik; Khodus, Georgiy; Niu, Zhigao; Thwala, Lungile Nomcebo; McCartney, Fiona; Simoff, Ivailo; Andersson, Ellen; Beloqui, Ana; Mabondzo, Aloise; Robla, Sandra; Webb, Dominic-Luc; Hellström, Per M.; Keita, Åsa V; Sima, Eduardo; Csaba, Noemi; Sundbom, Magnus; Preat, Veronique; Brayden, David J; Alonso, Maria Jose; Artursson, Per
Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat
Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene; Wegler, Christine; Johnson, Line K.; Hertel, Jens K.; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesaeth, Joran; Skovlund, Eva; Christensen, Hege; Jansson-Lofmark, Rasmus; Asberg, Anders; Molden, Espen; Robertsen, Ida
Correlations between 4 beta-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range
We aim to understand drug absorption and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.
We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery, to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery.
It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) which supports academic and industrial discovery projects with absorption, distribution, metabolism and excretion (ADME) as well as physicochemical profiling of compound libraries, hits and leads, and pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.