- ***Update – Symposium will be held online***
- The registration for the upcoming 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022 is now open
- ***SAVE THE DATE*** 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022
- 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development postponed to January 2022
- Unfortunately there are no upcoming events at this time
Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myohanen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe; Deguchi, Yoshiharu; Paalzow, Lennart; Sugiyama, Yuichi; Terasaki, Tetsuya; de Lange, Elizabeth C. M.
Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics
Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege; Krogstad, Veronica; Wegler, Christine; Angeles, Philip Carlo; Wollmann, Birgit Malene; Hole, Kristine; Johnson, Line Kristin; Sandbu, Rune; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesaeth, Jøran; Jansson-Löfmark, Rasmus; Åsberg, Anders
Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity: a non-randomized three-armed controlled trial
We aim to understand drug absorption and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.
We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery, to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery.
It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) which supports academic and industrial discovery projects with absorption, distribution, metabolism and excretion (ADME) as well as physicochemical profiling of compound libraries, hits and leads, and pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.