- ***Update – Symposium will be held online***
- The registration for the upcoming 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022 is now open
- ***SAVE THE DATE*** 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022
- 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development postponed to January 2022
Wegler, Christine; Wiśniewski, Jacek R; Robertsen, Ida; Christensen, Hege; Kristoffer Hertel, Jens; Hjelmesaeth, Jøran; Jansson-Löfmark, Rasmus; Åsberg, Anders; Andersson, Tommy B; Artursson, Per
Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity
Tremmel, Roman; Nies, Anne T.; van Eijck, Barbara A. C.; Handin, Niklas; Haag, Mathias; Winter, Stefan; Büttner, Florian A.; Kölz, Charlotte; Klein, Franziska; Mazzola, Pascale; Hofmann, Ute; Klein, Kathrin; Hoffmann, Per; Nöthen, Markus M.; Gaugaz, Fabienne Z.; Artursson, Per; Schwab, Matthias; Schaeffeler, Elke
Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
Hellinen, Laura; Koskela, Ali; Vattulainen, Elina; Liukkonen, Mikko; Wegler, Christine; Treyer, Andrea; Handin, Niklas; Svensson, Richard; Myohanen, Timo; Poso, Antti; Kaarniranta, Kai; Artursson, Per; Urtti, Arto
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
We aim to understand drug absorption and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.
We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery, to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery.
It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) which supports academic and industrial discovery projects with absorption, distribution, metabolism and excretion (ADME) as well as physicochemical profiling of compound libraries, hits and leads, and pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.