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Uppsala University Department of Pharmacy Research Drug Delivery Publications 2017

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About the department
Education
Research
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Publications 2017

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren, Maria; Simoff, Ivailo; Backlund, Maria; Wegler, Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 2909-2913, 2017.

DOI for A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Beloqui, Ana; Brayden, David J.; Artursson, Per; Preat, Veronique et al.

Part of Nature Protocols, p. 1387-1399, 2017.

DOI for A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation
Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Clulow, Andrew J.; Parrow, Albin; Hawley, Adrian; Khan, Jamal et al.

Part of Journal of Physical Chemistry B, p. 10869-10881, 2017.

DOI for Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid Download full text (pdf) of Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Open access
Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds

Andersson, Sara B. E.; Alvebratt, Caroline; Bergström, Christel

Part of Pharmaceutical research, p. 1805-1816, 2017.

DOI for Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds Download full text (pdf) of Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds

Open access
Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers

Yang, Jiaojiao; Alvebratt, Caroline; Zhang, Peng; Zardán Gómez de la Torre, Teresa et al.

Part of International Journal of Pharmaceutics, p. 183-190, 2017.

DOI for Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Wiita, Elisee; Almlof, Ingrid et al.

Part of Journal of Medicinal Chemistry, p. 2148-2154, 2017.

DOI for Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Mateus, André; Treyer, Andrea; Wegler, Christine; Karlgren, Maria et al.

Part of Scientific Reports, p. 1-12, 2017.

DOI for Intracellular drug bioavailability: a new predictor of system dependent drug disposition Download full text (pdf) of Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Open access
Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

Plum, Jakob; Madsen, Cecilie M.; Teleki, Alexandra; Bevernage, Jan et al.

Part of Molecular Pharmaceutics, p. 4161-4169, 2017.

DOI for Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method
Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Edueng, Khadijah; Mahlin, Denny; Larsson, Per; Bergström, Christel

Part of Journal of Controlled Release, p. 193-202, 2017.

DOI for Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways Download full text (pdf) of Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Open access
Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Larsson, Per; Alskär, Linda C.; Bergström, Christel

Part of Molecular Pharmaceutics, p. 4145-4153, 2017.

DOI for Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach Download full text (pdf) of Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Open access
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Llona-Minguez, Sabin; Höglund, Andreas; Ghassemian, Artin; Desroses, Matthieu et al.

Part of Journal of Medicinal Chemistry, p. 4279-4292, 2017.

DOI for Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Mateus, André; Gordon, Laurie J.; Wayne, Gareth J.; Almqvist, Helena et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E6231-E6239, 2017.

DOI for Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Open access
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines

Llona-Minguez, Sabin; Ghassemian, Artin; Baranczewski, Pawel; Desroses, Matthieu et al.

Part of MedChemComm, p. 1553-1560, 2017.

DOI for Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines
Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Pedersen, Jenny M.; Khan, Elin K.; Bergström, Christel; Palm, Johan et al.

Part of European Journal of Pharmaceutical Sciences, p. 70-76, 2017.

DOI for Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)
The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Edueng, Khadijah; Mahlin, Denny; Bergström, Christel

Part of Pharmaceutical Research, p. 1754-1772, 2017.

DOI for The Need for Restructuring the Disordered Science of Amorphous Drug Formulations Download full text (pdf) of The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Open access
Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewsk, Jacek R. et al.

Part of Molecular Pharmaceutics, p. 3142-3151, 2017.

DOI for Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes Download full text (pdf) of Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Open access

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