Publications 2016

50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Feeney, Orlagh M; Crum, Matthew F; McEvoy, Claire L; Trevaskis, Natalie L et al.

Part of Advanced Drug Delivery Reviews, p. 167-194, 2016.

DOI for 50 years of oral lipid-based formulations: Provenance, progress and future perspectives

A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Schowen, Katharine Barbara; Schowen, Richard L.; Borchardt, Susan E.; Borchardt, Paul M. et al.

Part of Journal of Pharmaceutical Sciences, p. 370-385, 2016.

DOI for A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Part of ACS Chemical Neuroscience, p. 1383-1392, 2016.

DOI for Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Almqvist, Helena; Axelsson, Hanna; Jafari, Rozbeh; Dan, Chen et al.

Part of Nature Communications, 2016.

DOI for CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil Download full text (pdf) of CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance

Vildhede, Anna; Wisniewski, Jacek; Norén, Agneta; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 96-96, 2016.

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Part of Journal of Pharmaceutical Sciences, p. 1017-1021, 2016.

DOI for Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Alhalaweh, Amjad; Bergström, Christel A. S.; Taylor, Lynne S.

Part of Journal of Controlled Release, p. 172-182, 2016.

DOI for Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergström, Christel A. S.; Charman, William N; Porter, Christopher J H

Part of Advanced Drug Delivery Reviews, p. 6-21, 2016.

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Development of MS- based immunoassays for Cytochrome P450 and transporter quantification

Hammer, H. S.; Poetz, O.; Artursson, Per; Wegler, Christine

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S47-S47, 2016.

Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Forsgren, Johan; Bergström, Christel et al.

Part of Journal of Pharmaceutical Sciences, p. 657-663, 2016.

DOI for Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Gordon, Laurie J; Allen, Morven; Artursson, Per; Hann, Michael M. et al.

Part of Journal of Biomolecular Screening, p. 156-164, 2016.

DOI for Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Jacques, Sylvain A.; Johanson, Lars et al.

Part of Journal of Medicinal Chemistry, p. 1140-1148, 2016.

DOI for Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Urdzik, Jozef; Vildhede, Anna; Wiśniewski, Jacek R.; Duraj, Frans et al.

Part of PROTEOMES, 2016.

DOI for Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases Download full text (pdf) of Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Impact of drug transporters on intracellular unbound drug concentrations

Mateus, André; Treyer, Andrea; Matsson, Par; Karlgren, Maria et al.

Part of Drug metabolism reviews (Softcover ed.), p. 147-147, 2016.

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

Wisniewski, Jacek R.; Vildhede, Anna; Norén, Agneta; Artursson, Per

Part of Journal of Proteomics, p. 234-247, 2016.

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Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Andersson, Sara B. E.; Alvebratt, Caroline; Bevernage, Jan; Bonneau, Damien et al.

Part of Journal of Pharmaceutical Sciences, p. 2864-2872, 2016.

DOI for Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Lipophilicity in Drug Development: Too Much or Not Enough?

Bergström, Christel A. S.; Yazdanian, Mehran

Part of AAPS Journal, p. 1095-1100, 2016.

DOI for Lipophilicity in Drug Development: Too Much or Not Enough?

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug metabolism reviews (Softcover ed.), p. 56-57, 2016.

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Part of Drug Metabolism And Disposition, p. 505-516, 2016.

DOI for Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

New cell-based approaches for better predictions of drug transport and cellular drug exposure

Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 7-7, 2016.

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Lundquist, Patrik; Artursson, Per

Part of Advanced Drug Delivery Reviews, p. 256-276, 2016.

DOI for Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues Download full text (pdf) of Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Holmboe, Michael; Larsson, Per; Anwar, Jamshed; Bergström, Christel

Part of Langmuir, p. 12732-12740, 2016.

DOI for Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations Download full text (pdf) of Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewski, Jacek R. et al.

Part of Drug metabolism reviews (Softcover ed.), p. 98-98, 2016.

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Gautschi, Nicolas; Bergström, Christel; Kuentz, Martin

Part of International Journal of Pharmaceutics, p. 164-174, 2016.

DOI for Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn; Matsson, Pär; Tyrchan, Christian; Artursson, Per et al.

Part of Nature Chemical Biology, p. 1065-+, 2016.

DOI for Structural and conformational determinants of macrocycle cell permeability

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Part of Analytical Biochemistry, p. 82-88, 2016.

DOI for Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions Download full text (pdf) of Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Welch, Ken; Bergström, Christel et al.

Part of European Journal of Pharmaceutical Sciences, p. 468-474, 2016.

DOI for Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

The Need for Speed-Kinetic Limits of Drug Transporters

Matsson, Pär X.; Lundquist, Patrik; Artursson, Per

Part of TIPS - Trends in Pharmacological Sciences, p. 243-245, 2016.

DOI for The Need for Speed-Kinetic Limits of Drug Transporters

The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

Miyake, Masateru; Ragnarsson, Eva; Nakai, Daisuke; Artursson, Per

Part of Journal of Pharmaceutical Sciences, p. 2099-2104, 2016.

DOI for The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Ölander, Magnus; Wiśniewski, Jacek R.; Matsson, Pär; Lundquist, Patrik et al.

Part of Journal of Pharmaceutical Sciences, p. 817-827, 2016.

DOI for The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Good, James A. D.; Silver, Jim; Nunez-Otero, Carlos; Bahnan, Wael et al.

Part of Journal of Medicinal Chemistry, p. 2094-2108, 2016.

DOI for Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

To attach or not to attach: factors behind variable adhesion properties of cryopreserved human hepatocytes

Ölander, Magnus; Wisniewski, Jacek; Norén, Agneta; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 103-103, 2016.

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Alskär, Linda C.; Porter, Christopher J. H.; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 251-261, 2016.

DOI for Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Bergström, Christel A. S.; Porter, Christopher J. H.

Part of Advanced Drug Delivery Reviews, p. 1-5, 2016.

DOI for Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Validation and development of MTH1 inhibitors for treatment of cancer

Berglund, U. Warpman; Sanjiv, K.; Gad, H.; Kalderen, C. et al.

Part of Annals of Oncology, p. 2275-2283, 2016.

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