Publications 2015 and earlier
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Addendum to 'Quantifying the impact of transporters on cellular drug permeability'
Part of TIPS - Trends in Pharmacological Sciences, p. 559-559, 2015.
DOI for Addendum to 'Quantifying the impact of transporters on cellular drug permeability'
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Breaking the intestinal barrier to deliver drugs
Part of Science, p. 716-717, 2015.
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Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure
Part of Journal of Proteome Research, p. 3305-3314, 2015.
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Computational modeling to predict the functions and impact of drug transporters
Part of In silico pharmacology, 2015.
DOI for Computational modeling to predict the functions and impact of drug transporters Download full text (pdf) of Computational modeling to predict the functions and impact of drug transporters
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Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
Part of Pharmaceutical research, p. 578-589, 2015.
DOI for Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid Download full text (pdf) of Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
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Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
Part of European Journal of Pharmaceutical Sciences, p. 12-20, 2015.
DOI for Concomitant intake of alcohol may increase the absorption of poorly soluble drugs Download full text (pdf) of Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
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Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance
Part of Drug metabolism reviews (Softcover ed.), p. 245-246, 2015.
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Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
Part of Current molecular biology reports, p. 141-147, 2015.
DOI for Models for Predicting Drug Absorption From Oral Lipid-Based Formulations Download full text (pdf) of Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
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Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability
Part of International Journal of Pharmaceutics, p. 312-317, 2015.
DOI for Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Download full text (pdf) of Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability
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Quantifying the impact of transporters on cellular drug permeability.
Part of TIPS - Trends in Pharmacological Sciences, p. 255-262, 2015.
DOI for Quantifying the impact of transporters on cellular drug permeability. Download full text (pdf) of Quantifying the impact of transporters on cellular drug permeability.
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Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo
Part of European Journal of Medicinal Chemistry, p. 191-209, 2015.
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A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
Part of Journal of Medicinal Chemistry, p. 3005-3010, 2014.
DOI for A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
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Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket
Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014.
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Computational predictions of glass-forming ability and crystallization tendency of drug molecules
Part of Molecular Pharmaceutics, p. 3123-3132, 2014.
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Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014.
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Experimental and Computational Prediction of Glass Transition Temperature of Drugs
Part of JOURNAL OF CHEMICAL INFORMATION AND MODELING, p. 3396-3403, 2014.
DOI for Experimental and Computational Prediction of Glass Transition Temperature of Drugs
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Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues
Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014.
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Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis
Part of PLOS ONE, p. e110918-, 2014.
DOI for Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis Download full text (pdf) of Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis
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Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions
Part of Drug Metabolism And Disposition, p. 1210-1218, 2014.
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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties
Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014.
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Is the full potential of the biopharmaceutics classification system reached?
Part of European Journal of Pharmaceutical Sciences, p. 224-231, 2014.
DOI for Is the full potential of the biopharmaceutics classification system reached?
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Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.
DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
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Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition
Part of Molecular Pharmaceutics, p. 1727-1738, 2014.
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Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei
Part of Journal of Medicinal Chemistry, p. 6393-6402, 2014.
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Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles
Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.
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An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux
Part of Molecular Pharmaceutics, p. 3152-3163, 2013.
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Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
Part of Pharmaceutical research, p. 3225-3237, 2013.
DOI for Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Download full text (pdf) of Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
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Computational Prospecting for Drug-Transporter Interactions
Part of Clinical Pharmacology and Therapeutics, p. 30-32, 2013.
DOI for Computational Prospecting for Drug-Transporter Interactions
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Constrained H-Phe-Phe-NH2 Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability
Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013.
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Early drug development predictions of glass-forming ability and physical stability of drugs
Part of European Journal of Pharmaceutical Sciences, p. 323-332, 2013.
DOI for Early drug development predictions of glass-forming ability and physical stability of drugs Download full text (pdf) of Early drug development predictions of glass-forming ability and physical stability of drugs
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Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
Part of Toxicological Sciences, p. 328-343, 2013.
DOI for Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Download full text (pdf) of Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
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Early recognition of absorption challenges of contemporary targets:: key molecular properties and in silico tools
Part of Bulletin Technique Gattefossé, p. 50-57, 2013.
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Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis
Part of Molecular Pharmaceutics, p. 2823-2848, 2013.
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Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice
Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013.
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Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat
Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 117-128, 2013.
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Rapid Measurement of Intracellular Unbound Drug Concentrations
Part of Molecular Pharmaceutics, p. 2467-2478, 2013.
DOI for Rapid Measurement of Intracellular Unbound Drug Concentrations
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The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox
Part of Toxicology in Vitro, p. 1357-1376, 2013.
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Caco-2 monolayers in experimental and theoretical predictions of drug transport
Part of Advanced Drug Delivery Reviews, p. 280-289, 2012.
DOI for Caco-2 monolayers in experimental and theoretical predictions of drug transport
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Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions
Part of Journal of Medicinal Chemistry, p. 4740-4763, 2012.
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Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset
Part of Pharmaceutical research, p. 3131-3142, 2012.
DOI for Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset
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Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid
Part of Molecular Pharmaceutics, p. 1942-1952, 2012.
DOI for Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid
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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
Part of Drug Discovery Today, p. 905-912, 2012.
DOI for Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
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Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions
Part of The Pharmacogenomics Journal, p. 400-411, 2011.
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Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors
Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011.
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Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development
Part of Molecular Pharmaceutics, p. 498-506, 2011.
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A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery
Part of Molecular pharmaceutics, p. 1478-1487, 2010.
DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery
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Coexistence of passive and carrier-mediated processes in drug transport
Part of Nature reviews. Drug discovery, p. 597-614, 2010.
DOI for Coexistence of passive and carrier-mediated processes in drug transport
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Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media
Part of Molecular pharmaceutics, p. 1419-1430, 2010.
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In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation
Part of Bioorganic & Medicinal Chemistry, p. 5896-5902, 2010.
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Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte
Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010.
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Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)
Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010.
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Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking
Part of Biomaterials, p. 975-987, 2010.
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Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models
Part of Journal of Pharmaceutical Sciences, p. 2166-2175, 2010.
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Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)
Part of Drug metabolism reviews (Softcover ed.), p. 305-306, 2010.
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Uptake mechanism of ochratoxin A and citrinin through human liver
Part of Drug metabolism reviews (Softcover ed.), p. 315-315, 2010.
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Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs
Part of Drug Metabolism And Disposition, p. 2275-2283, 2009.
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Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells
Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.
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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs
Part of Pharmaceutical research, p. 1816-1831, 2009.
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Part of European Journal of Pharmaceutical Sciences, p. 383-396, 2008.
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Molecular characteristics for solid-state limited solubility
Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008.
DOI for Molecular characteristics for solid-state limited solubility
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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)
Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008.
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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008.
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Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties
Part of Biomacromolecules, p. 3268-76, 2008.
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Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis
Part of Laboratory investigation; a journal of technical methods and pathology, p. 1215-26, 2008.
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A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)
Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007.
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Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers
Part of Journal of drug delivery science and technology, p. 259-266, 2007.
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Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1
Part of Journal of Medicinal Chemistry, p. 5238-5242, 2007.
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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
Part of Nature Protocols, p. 2111-2119, 2007.
DOI for Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
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Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)
Part of Inflammatory Bowel Diseases, p. 291-297, 2007.
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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
Part of Drug Metabolism And Disposition, p. 1333-1340, 2007.
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Photoinduced Formation of N2 Molecules in Ammonium Compounds
Part of Journal of Physical Chemistry A, p. 9662-9669, 2007.
DOI for Photoinduced Formation of N2 Molecules in Ammonium Compounds
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Poorly soluble marketed drugs display solvation limited solubility
Part of Journal of Medicinal Chemistry, p. 5858-5862, 2007.
DOI for Poorly soluble marketed drugs display solvation limited solubility
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Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.
Part of Lab Invest, p. 504-16, 2006.
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Contribution of solid-state properties to the aqueous solubility of drugs.
Part of Eur J Pharm Sci, p. 294-305, 2006.
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Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery
Part of Pharmaceutical research, p. 475-482, 2006.
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Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches
Part of Journal of Pharmacology and Experimental Therapeutics, p. 632-639, 2006.
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Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.
Part of Pharm Res, p. 350-9, 2006.
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Prediction of ADMET Properties.
Part of ChemMedChem, p. 920-937, 2006.
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Prediction of ADMET Properties
Part of ChemMedChem, p. 920-937, 2006.
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Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.
Part of Drug Metab Dispos, p. 1423-31, 2006.
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Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
Part of European Journal of Pharmaceutical Sciences, p. 269-277, 2006.
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Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo
Part of Journal of Controlled Release, p. 103-112, 2006.
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A miniaturized nebulization catheter for improved gene delivery to the mouse lung.
Part of J Gene Med, p. 1215-22, 2005.
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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.
Part of Eur J Pharm Sci, p. 333-49, 2005.
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Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study
Part of Analytical Chemistry, p. 5488-5493, 2005.
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Computational models to predict aqueous drug solubility, permeability and intestinal absorption
Part of Expert opinion on drug metabolism & toxicology, p. 613-627, 2005.
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Exploring the role of different drug transport routes in permeability screening.
Part of J Med Chem, p. 604-13, 2005.
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Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.
Part of Int J Pharm, p. 127-, 2005.
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Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Part of Xenobiotica, p. 785-96, 2005.
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Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.
Part of Antimicrob Agents Chemother, p. 1087-92, 2005.
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Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.
Part of Eur J Pharm Sci, p. 455-65, 2005.
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X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.
Part of J Electr Spectr, p. 283-285, 2005.
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Accuracy of calculated pH-dependent aqueous drug solubility.
Part of Eur J Pharm Sci, p. 387-98, 2004.
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Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.
Part of J Pharm Sci, p. 2972-84, 2004.
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Global and local computational models for aqueous solubility prediction of drug-like molecules.
Part of J Chem Inf Comput Sci, p. 1477-88, 2004.
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Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.
Part of Gene Ther, p. 1441-52, 2004.
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Theoretical predictions of drug absorption in drug discovery and development
Part of Clinical Pharmacokinetics, p. 877-899, 2002.