Publications 2015 and earlier

Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Matsson, Pär; Fenu, Luca A.; Lundquist, Patrik; Wisniewski, Jacek R. et al.

Part of TIPS - Trends in Pharmacological Sciences, p. 559-559, 2015.

DOI for Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Breaking the intestinal barrier to deliver drugs

Artursson, Per; Knight, Stefan

Part of Science, p. 716-717, 2015.

DOI for Breaking the intestinal barrier to deliver drugs

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Vildhede, Anna; Wisniewski, Jacek R.; Noren, Agneta; Karlgren, Maria et al.

Part of Journal of Proteome Research, p. 3305-3314, 2015.

DOI for Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Computational modeling to predict the functions and impact of drug transporters

Matsson, Pär; Bergström, Christel A S

Part of In silico pharmacology, 2015.

DOI for Computational modeling to predict the functions and impact of drug transporters Download full text (pdf) of Computational modeling to predict the functions and impact of drug transporters

Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Fagerberg, Jonas H.; Karlsson, Eva; Ulander, Johan; Hanisch, Gunilla et al.

Part of Pharmaceutical research, p. 578-589, 2015.

DOI for Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid Download full text (pdf) of Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 12-20, 2015.

DOI for Concomitant intake of alcohol may increase the absorption of poorly soluble drugs Download full text (pdf) of Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance

Karlgren, Maria; Vildhede, Anna; Ölander, Magnus; Wisniewski, Jacek et al.

Part of Drug metabolism reviews (Softcover ed.), p. 245-246, 2015.

Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Fagerberg, Jonas H; Bergström, Christel A S

Part of Therapeutic delivery, p. 935-959, 2015.

DOI for Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Persson, Linda C.; Bergström, Christel A S

Part of Current molecular biology reports, p. 141-147, 2015.

DOI for Models for Predicting Drug Absorption From Oral Lipid-Based Formulations Download full text (pdf) of Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Alhalaweh, Amjad; Alzghoul, Ahmad; Mahlin, Denny; Bergström, Christel A. S.

Part of International Journal of Pharmaceutics, p. 312-317, 2015.

DOI for Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Download full text (pdf) of Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Part of ChemMedChem, p. 455-460, 2015.

DOI for Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Quantifying the impact of transporters on cellular drug permeability.

Matsson, Pär; Fenu, Luca A; Lundquist, Patrik; Wiśniewski, Jacek R et al.

Part of TIPS - Trends in Pharmacological Sciences, p. 255-262, 2015.

DOI for Quantifying the impact of transporters on cellular drug permeability. Download full text (pdf) of Quantifying the impact of transporters on cellular drug permeability.

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene et al.

Part of European Journal of Medicinal Chemistry, p. 191-209, 2015.

DOI for Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Mateus, André; Matsson, Pär; Artursson, Per

Part of Journal of Medicinal Chemistry, p. 3005-3010, 2014.

DOI for A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014.

DOI for Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Alhalaweh, Amjad; Alzghoul, Ahmad; Kaialy, Waseem; Mahlin, Denny et al.

Part of Molecular Pharmaceutics, p. 3123-3132, 2014.

DOI for Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Part of European Journal of Pharmaceutical Sciences, p. 173-199, 2014.

DOI for Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Alzghoul, Ahmad; Alhalaweh, Amjad; Mahlin, Denny; Bergström, Christel A. S.

Part of JOURNAL OF CHEMICAL INFORMATION AND MODELING, p. 3396-3403, 2014.

DOI for Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Part of ACS Medicinal Chemistry Letters, p. 1272-1277, 2014.

DOI for Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pedersen, Christian; Slepenkin, Anatoly; Andersson, Sara B. E.; Fagerberg, Jonas H. et al.

Part of PLOS ONE, p. e110918-, 2014.

DOI for Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis Download full text (pdf) of Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede, Anna; Karlgren, Maria; Svedberg, Elin K.; Wisniewski, Jacek R. et al.

Part of Drug Metabolism And Disposition, p. 1210-1218, 2014.

DOI for Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Part of Journal of Medicinal Chemistry, p. 2746-2754, 2014.

DOI for Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Is the full potential of the biopharmaceutics classification system reached?

Bergström, Christel A. S.; Andersson, Sara B. E.; Fagerberg, Jonas H.; Ragnarsson, Gert et al.

Part of European Journal of Pharmaceutical Sciences, p. 224-231, 2014.

DOI for Is the full potential of the biopharmaceutics classification system reached?

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge; Koolmeister, Tobias; Jemth, Ann-Sofie; Eshtad, Saeed et al.

Part of Nature, p. 215-221, 2014.

DOI for MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.

DOI for Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis; Artursson, Per; Avdeef, Alex; Di, Li et al.

Part of Molecular Pharmaceutics, p. 1727-1738, 2014.

DOI for Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna et al.

Part of Journal of Medicinal Chemistry, p. 6393-6402, 2014.

DOI for Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.

DOI for Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Part of Cell, p. 313-328, 2014.

DOI for Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve, Etienne P. A.; Artursson, Per; Ingelman-Sundberg, Magnus; Karlgren, Maria

Part of Molecular Pharmaceutics, p. 3152-3163, 2013.

DOI for An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Ohrvik, Helena; Tydén, Eva; Artursson, Per; Oskarsson, Agneta et al.

Part of ISRN Toxicology, 2013.

DOI for Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Part of Molecular Pharmaceutics, p. 4252-4262, 2013.

DOI for Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Persson, Linda C.; Porter, Christopher J. H.; Charman, William N.; Bergström, Christel A. S.

Part of Pharmaceutical research, p. 3225-3237, 2013.

DOI for Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Download full text (pdf) of Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Computational Prospecting for Drug-Transporter Interactions

Matsson, Pär; Artursson, Per

Part of Clinical Pharmacology and Therapeutics, p. 30-32, 2013.

DOI for Computational Prospecting for Drug-Transporter Interactions

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013.

DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Early drug development predictions of glass-forming ability and physical stability of drugs

Mahlin, Denny; Bergström, Christel A. S.

Part of European Journal of Pharmaceutical Sciences, p. 323-332, 2013.

DOI for Early drug development predictions of glass-forming ability and physical stability of drugs Download full text (pdf) of Early drug development predictions of glass-forming ability and physical stability of drugs

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Part of Toxicological Sciences, p. 328-343, 2013.

DOI for Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Download full text (pdf) of Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Early recognition of absorption challenges of contemporary targets:: key molecular properties and in silico tools

Bergström, Christel A S

Part of Bulletin Technique Gattefossé, p. 50-57, 2013.

Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Warren, Dallas B.; Bergström, Christel A. S.; Benameur, Hassan; Porter, Christopher J. H. et al.

Part of Molecular Pharmaceutics, p. 2823-2848, 2013.

DOI for Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Part of Journal of Medicinal Chemistry, p. 2690-2694, 2013.

DOI for Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Johansson, Carl-Christer; Gennemark, Peter; Artursson, Per; Abelo, Angela et al.

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 117-128, 2013.

DOI for Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Rapid Measurement of Intracellular Unbound Drug Concentrations

Mateus, André; Matsson, Pär; Artursson, Per

Part of Molecular Pharmaceutics, p. 2467-2478, 2013.

DOI for Rapid Measurement of Intracellular Unbound Drug Concentrations

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B. et al.

Part of Toxicology in Vitro, p. 1357-1376, 2013.

DOI for The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Caco-2 monolayers in experimental and theoretical predictions of drug transport

Artursson, Per; Palm, Katrin; Luthman, Kristina

Part of Advanced Drug Delivery Reviews, p. 280-289, 2012.

DOI for Caco-2 monolayers in experimental and theoretical predictions of drug transport

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Karlgren, Maria; Vildhede, Anna; Norinder, Ulf; Wisniewski, Jacek R. et al.

Part of Journal of Medicinal Chemistry, p. 4740-4763, 2012.

DOI for Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Bergstrom, Christel A. S.; Charman, Susan A.; Nicolazzo, Joseph A.

Part of Pharmaceutical research, p. 3131-3142, 2012.

DOI for Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Fagerberg, Jonas H.; Al-Tikriti, Yassir; Ragnarsson, Gert; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 1942-1952, 2012.

DOI for Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F. et al.

Part of Drug Discovery Today, p. 905-912, 2012.

DOI for Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Part of Pharmaceutical research, p. 411-426, 2012.

DOI for In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

mRNA expression of drug-transporting proteins along the human intestine and comparison with expression in Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Lazorova, Lucia et al.

2012.

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions

Ahlin, Gustav; Chen, L; Lazorova, Lucia; Chen, Ying et al.

Part of The Pharmacogenomics Journal, p. 400-411, 2011.

DOI for Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Part of Journal of Pharmaceutical Sciences, p. 3763-3772, 2011.

DOI for Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Mahlin, Denny; Ponnambalam, Sopana; Hockerfelt, Mina Heidarian; Bergström, Christel A. S.

Part of Molecular Pharmaceutics, p. 498-506, 2011.

DOI for Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Part of Molecular pharmaceutics, p. 1478-1487, 2010.

DOI for A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex et al.

Part of Nature reviews. Drug discovery, p. 597-614, 2010.

DOI for Coexistence of passive and carrier-mediated processes in drug transport

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H.; Tsinman, Oksana; Sun, Na; Tsinman, Konstantin et al.

Part of Molecular pharmaceutics, p. 1419-1430, 2010.

DOI for Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Bose, Partha Pratim; Chatterjee, Urmimala; Hubatsch, Ina; Artursson, Per et al.

Part of Bioorganic & Medicinal Chemistry, p. 5896-5902, 2010.

DOI for In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 306-307, 2010.

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Part of Drug metabolism reviews (Softcover ed.), p. 304-305, 2010.

Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Strand, Sabina P; Lelu, Sylvie; Reitan, Nina K; de Lange Davies, Catharina et al.

Part of Biomaterials, p. 975-987, 2010.

DOI for Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Linnankoski, Johanna; Mäkelä, Johanna; Palmgren, Joni; Mauriala, Timo et al.

Part of Journal of Pharmaceutical Sciences, p. 2166-2175, 2010.

DOI for Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)

Karlgren, Maria; Ahlin, Gustav; Vildhede, Anna; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 305-306, 2010.

Uptake mechanism of ochratoxin A and citrinin through human liver

Gao, Ge; Karlgren, Maria; Artursson, Per

Part of Drug metabolism reviews (Softcover ed.), p. 315-315, 2010.

Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Ahlin, Gustav; Hilgendorf, Constanze; Karlsson, Johan; Al-Khalili Szigyarto, Cristina et al.

Part of Drug Metabolism And Disposition, p. 2275-2283, 2009.

DOI for Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Part of European Journal of Pharmaceutical Sciences, p. 556-563, 2009.

DOI for Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Part of Pharmaceutical research, p. 1816-1831, 2009.

DOI for Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Hayeshi, Rose; Hilgendorf, Constanze; Artursson, Per; Augustijns, Patrick et al.

Part of European Journal of Pharmaceutical Sciences, p. 383-396, 2008.

DOI for Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Part of Journal of Medicinal Chemistry, p. 3035-3039, 2008.

DOI for Molecular characteristics for solid-state limited solubility

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Part of Journal of Medicinal Chemistry, p. 3275-3287, 2008.

DOI for Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Part of Journal of Medicinal Chemistry, p. 5932-5942, 2008.

DOI for Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Strand, Sabina P; Issa, Mohamed M; Christensen, Bjørn E; Vårum, Kjell M et al.

Part of Biomacromolecules, p. 3268-76, 2008.

DOI for Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

Ragnarsson, Eva G E; Schoultz, Ida; Gullberg, Elisabet; Carlsson, Anders H et al.

Part of Laboratory investigation; a journal of technical methods and pathology, p. 1215-26, 2008.

DOI for Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 19-30, 2007.

DOI for A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers

Neuhoff, Sibylle; Artursson, Per; Ungell, Anna-Lena

Part of Journal of drug delivery science and technology, p. 259-266, 2007.

Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Hubatsch, Ina; Arvidsson, Per I.; Seebach, Dieter; Luthman, Kristina et al.

Part of Journal of Medicinal Chemistry, p. 5238-5242, 2007.

DOI for Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per

Part of Nature Protocols, p. 2111-2119, 2007.

DOI for Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Englund, Gunilla; Jacobson, Annica; Rorsman, Fredrik; Artursson, Per et al.

Part of Inflammatory Bowel Diseases, p. 291-297, 2007.

DOI for Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Hilgendorf, Constanze; Ahlin, Gustav; Seithel, Annick; Artursson, Per et al.

Part of Drug Metabolism And Disposition, p. 1333-1340, 2007.

DOI for Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Aziz, Emad F; Gråsjö, Johan; Forsberg, Johan; Andersson, Egil et al.

Part of Journal of Physical Chemistry A, p. 9662-9669, 2007.

DOI for Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Poorly soluble marketed drugs display solvation limited solubility

Bergström, Christel; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina

Part of Journal of Medicinal Chemistry, p. 5858-5862, 2007.

DOI for Poorly soluble marketed drugs display solvation limited solubility

Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.

Keita, Åsa V; Gullberg, Elisabet; Ericson, Ann-Charlott; Salim, Sa'ad Y et al.

Part of Lab Invest, p. 504-16, 2006.

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Part of Eur J Pharm Sci, p. 294-305, 2006.

Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Regnström, Karin; Ragnarsson, Eva GE; Fryknäs, Mårten; Köping-Höggård, Magnus et al.

Part of Pharmaceutical research, p. 475-482, 2006.

DOI for Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Gullberg, Elisabet; Keita, Åsa V.; Salim, Sa'ad Y.; Andersson, Margaretha et al.

Part of Journal of Pharmacology and Experimental Therapeutics, p. 632-639, 2006.

DOI for Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.

Neuhoff, Sibylle; Artursson, Per; Zamora, Ismael; Ungell, Anna-Lena

Part of Pharm Res, p. 350-9, 2006.

Prediction of ADMET Properties.

Norinder, U; Bergström, C

Part of ChemMedChem, p. 920-937, 2006.

Prediction of ADMET Properties

Norinder, Ulf; Bergström, Christel

Part of ChemMedChem, p. 920-937, 2006.

DOI for Prediction of ADMET Properties

Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

Sai, Yoshimichi; Kaneko, Yosuke; Ito, Satsuki; Mitsuoka, Keisuke et al.

Part of Drug Metab Dispos, p. 1423-31, 2006.

Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Karlbom, Urban et al.

Part of European Journal of Pharmaceutical Sciences, p. 269-277, 2006.

DOI for Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

Issa, Mohamed; Köping-Höggård, Magnus; Tammeraas, Kristoffer; Vårum, Kjell M. et al.

Part of Journal of Controlled Release, p. 103-112, 2006.

DOI for Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

A miniaturized nebulization catheter for improved gene delivery to the mouse lung.

Köping-Höggård, Magnus; Issa, Mohamed M; Köhler, Tamara; Tronde, Ann et al.

Part of J Gene Med, p. 1215-22, 2005.

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.

Avdeef, Alex; Artursson, Per; Neuhoff, Sibylle; Lazorova, Lucia et al.

Part of Eur J Pharm Sci, p. 333-49, 2005.

Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study

Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Part of Analytical Chemistry, p. 5488-5493, 2005.

Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Bergström, Christel

Part of Expert opinion on drug metabolism & toxicology, p. 613-627, 2005.

DOI for Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Exploring the role of different drug transport routes in permeability screening.

Matsson, Pär; Bergström, Christel A S; Nagahara, Naoki; Tavelin, Staffan et al.

Part of J Med Chem, p. 604-13, 2005.

Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.

Feith, G; Lindberg, S; Itoh, K; Okada, N et al.

Part of Int J Pharm, p. 127-, 2005.

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.

Yasar, U; Annas, A; Svensson, J-O; Lazorova, L et al.

Part of Xenobiotica, p. 785-96, 2005.

Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.

Hubatsch, Ina; Lazorova, Lucia; Vahlne, Anders; Artursson, Per

Part of Antimicrob Agents Chemother, p. 1087-92, 2005.

Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.

des Rieux, Anne; Ragnarsson, Eva G E; Gullberg, Elisabet; Preat, Veronique et al.

Part of Eur J Pharm Sci, p. 455-65, 2005.

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Part of J Electr Spectr, p. 283-285, 2005.

Accuracy of calculated pH-dependent aqueous drug solubility.

Bergström, Christel A S; Luthman, Kristina; Artursson, Per

Part of Eur J Pharm Sci, p. 387-98, 2004.

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Englund, Gunilla; Hallberg, Pär; Artursson, Per; Michaëlsson, Karl et al.

Part of BMC Medicine, p. 8-, 2004.

DOI for Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.

Nagahara, Naoki; Tavelin, Staffan; Artursson, Per

Part of J Pharm Sci, p. 2972-84, 2004.

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker ofMDR1-dependent drug efflux activity.

Taipalensuu, J; Tavelin, S; Lazorova, L; Svensson, AC et al.

Part of Eur J Pharm Sci, p. 69-, 2004.

Global and local computational models for aqueous solubility prediction of drug-like molecules.

Bergström, Christel A S; Wassvik, Carola M; Norinder, Ulf; Luthman, Kristina et al.

Part of J Chem Inf Comput Sci, p. 1477-88, 2004.

Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.

Köping-Höggård, M; Vårum, K M; Issa, M; Danielsen, S et al.

Part of Gene Ther, p. 1441-52, 2004.

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Part of Clinical Pharmacokinetics, p. 877-899, 2002.