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Uppsala University Department of Pharmacy Research Drug Delivery Publications 2018

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Publikationer 2018

A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions

Alvebratt, Caroline; Cheung, Ocean; Strömme, Maria; Bergström, Christel A. S.

Part of AAPS PharmSciTech, p. 2859-2865, 2018.

DOI for A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions Download full text (pdf) of A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions

Open access
Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen

Yang, Jiaojiao; Alvebratt, Caroline; Lu, Xi; Bergström, Christel et al.

Part of International Journal of Pharmaceutics, p. 515-521, 2018.

DOI for Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

Part of Scientific Reports, 2018.

DOI for Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound Download full text (pdf) of Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

Open access
Automated assays for thermodynamic (equilibrium) solubility determination.

Sou, Tomás; Bergström, Christel

Part of Drug Discovery Today, p. 11-19, 2018.

DOI for Automated assays for thermodynamic (equilibrium) solubility determination.
Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Keemink, Janneke; Bergström, Christel

Part of Pharmaceutical research, 2018.

DOI for Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations Download full text (pdf) of Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Open access
Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

Bergström, Christel A S; Larsson, Per

Part of International Journal of Pharmaceutics, p. 185-193, 2018.

DOI for Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting Download full text (pdf) of Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

Open access
CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Part of Drug Metabolism And Disposition, p. 1776-1786, 2018.

DOI for CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiss, Frederik; Hammer, Helen S.; Klein, Kathrin; Planatscher, Hannes et al.

Part of Drug Metabolism And Disposition, p. 387-396, 2018.

DOI for Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates Download full text (pdf) of Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Open access
Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Alskär, Linda C.; Keemink, Janneke; Johannesson, Jenny; Porter, Christopher J H et al.

Part of Molecular Pharmaceutics, p. 4733-4744, 2018.

DOI for Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations Download full text (pdf) of Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Open access
In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

Tsume, Yasuhiro; Patel, Sanjaykumar; Fotaki, Nikoletta; Bergström, Christel et al.

Part of AAPS Journal, 2018.

DOI for In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance
Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Treyer, Andrea; Mateus, André; Wisniewski, Jacek R.; Boriss, Hinnerk et al.

Part of Molecular Pharmaceutics, p. 2224-2233, 2018.

DOI for Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids Download full text (pdf) of Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

Open access
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

Part of Genome Medicine, 2018.

DOI for Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Visnes, Torkild; Cazares-Korner, Armando; Hao, Wenjing; Wallner, Olov et al.

Part of Science, p. 834-839, 2018.

DOI for Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

Shrestha, Neha; Bouttefeux, Oriane; Vanvarenberg, Kevin; Lundquist, Patrik et al.

Part of Nanoscale, p. 603-613, 2018.

DOI for The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

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