Publications

  • Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

    Global variability analysis of mRNA and protein concentrations across and within human tissues

    Part of NAR genomics and bioinformatics, 2020.

    Open access
  • Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

    A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

    Part of Drug Metabolism And Disposition, p. 8-17, 2020.

  • Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E. et al.

    Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

    Part of AAPS Journal, 2020.

    Open access
  • Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

    Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

    Part of Nature Communications, 2020.

    Open access
  • Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena et al.

    Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

    Part of Molecular Pharmaceutics, p. 1458-1469, 2020.

  • Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

    Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

    Part of Pharmaceutics, 2020.

    Open access
  • Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N. et al.

    Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

    Part of Frontiers in Chemistry, 2020.

    Open access
  • Hedge, Oliver; Bergström, Christel A. S.

    Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

    Part of Pharmaceutical research, 2020.

    Open access
  • Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

    Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

    Part of Pharmaceutics, 2020.

    Open access
  • Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per

    Cell-type-resolved proteomic analysis of the human liver

    Part of Liver international (Print), p. 1770-1780, 2020.

    Open access
  • Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik

    MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

    Part of Journal of Computational Chemistry, p. 1564-1569, 2020.

  • Bergström, Christel; Llinas, Antonio

    Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

    Part of ADMET & DMPK, p. 176-179, 2020.

    Open access
  • Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

    Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.

    Part of Journal of Pharmaceutical Sciences, 2020.

  • El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

    Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

    Part of Molecular Pharmaceutics, p. 4018-4028, 2020.

  • Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean et al.

    In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

    Part of Pharmaceutics, 2020.

    Open access
  • Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean et al.

    An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

    Part of European journal of pharmaceutics and biopharmaceutics, p. 21-29, 2020.

    Open access
  • Artursson, Per; Lundquist, Patrik

    A new opening for orally taken peptide drugs

    Part of Nature Biomedical Engineering, p. 12-13, 2020.

  • Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J. et al.

    Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

    Part of ACS Omega, p. 25733-25746, 2020.

    Open access
  • Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver et al.

    Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

    Part of Molecular Pharmaceutics, p. 4226-4240, 2020.

    Open access
  • Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

    Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

    Part of Molecular Pharmaceutics, p. 3837-3844, 2020.

    Open access
  • Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath et al.

    TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

    Part of Angewandte Chemie International Edition, 2020.

    Open access
  • Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z et al.

    The Critical Role of Passive Permeability in Designing Successful Drugs

    Part of ChemMedChem, 2020.

  • Larsson, Per; Kabedev, Aleksei; Hossain, Md Shakhawath; Hubert, Madlen

    Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

    Part of Journal of Pharmaceutical Sciences, 2020.

    Open access
  • Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida et al.

    Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

    Part of Clinical Pharmacology and Therapeutics, 2020.

  • Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

    Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

    Part of Journal of Pharmaceutical Sciences, p. 630-640, 2019.

    Open access
  • Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.

    Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

    Part of Journal of Pharmaceutical Sciences, p. 252-259, 2019.

    Open access
  • Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

    Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

    Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S8-S8, 2019.

  • Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S. et al.

    Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

    Part of Journal of Pharmaceutical Sciences, p. 2-7, 2019.

  • Artursson, Per

    Experimental approaches to understand intracellular based drug bioavailability

    Part of Drug Metabolism and Pharmacokinetics, p. S3-S3, 2019.

  • Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

    Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

    Part of Scientific Reports, 2019.

    Open access
  • Keemink, Janneke; Martensson, Elin; Bergström, Christel

    Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

    Part of Molecular Pharmaceutics, p. 921-930, 2019.

    Open access
  • Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

    A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

    Part of Archives of Toxicology, p. 819-829, 2019.

    Open access
  • Bergström, Christel A.S.; Avdeef, Alex

    Perspectives in solubility measurement and interpretation

    Part of ADMET AND DMPK, p. 88 88-105 105, 2019.

    Open access
  • Ölander, Magnus; Handin, Niklas; Artursson, Per

    Image-based quantification of cell debris as a measure of apoptosis

    Part of Analytical Chemistry, p. 5548-5552, 2019.

    Open access
  • Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne et al.

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Part of European journal of pharmaceutics and biopharmaceutics, p. 101-114, 2019.

  • Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

    Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

    Part of Journal of Proteome Research, p. 217-224, 2019.

    Open access
  • Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

    Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

    Part of AAPS Journal, 2019.

    Open access
  • Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

    The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

    Part of International Journal of Pharmaceutics, p. 264-281, 2019.

  • Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

    Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

    Part of Journal of Pharmaceutical Sciences, p. 1765-1771, 2019.

    Open access
  • Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin et al.

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Part of European Journal of Pharmaceutical Sciences, 2019.

    Open access
  • Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia et al.

    Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

    Part of Molecules, 2019.

    Open access
  • Alvebratt, Caroline; Denning, T.; Prestidge, Cliff; Bergström, Christel et al.

    Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier

    Part of Preclinical Form and Formulation for Drug Discovery, Gordon Research Conference 2019, 2019.

  • Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

    Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

    Part of Pharmaceutics, 2019.

  • Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019.

  • Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

    The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

    Part of Molecular Pharmaceutics, p. 4636-4650, 2019.

  • Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

    A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

    Part of Pharmaceutical research, 2019.

    Open access
  • Hossain, Md Shakhawath; Berg, Staffan; Bergström, Christel; Larsson, Per

    Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

    Part of AAPS PharmSciTech, 2019.

    Open access
  • Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel et al.

    Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

    Part of European journal of pharmaceutics and biopharmaceutics, p. 46-55, 2019.

    Open access
  • Knijnenburg, Jesper T.N.; Posavec, Lidija; Teleki, Alexandra

    Chapter 4 - Nanostructured Minerals and Vitamins for Food Fortification and Food Supplementation

    Part of Nanomaterials for Food Applications, p. 63-98, 2019.

  • Alskär, Linda C.; Parrow, Albin; Keemink, Janneke; Pernilla, Johansson et al.

    Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

    Part of Journal of Controlled Release, p. 90-100, 2019.

    Open access