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Biopharmaceutics

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Uppsala University Department of Pharmacy Research Biopharmaceutics Publications

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Biopharmaceutics

Research
Degree project
Equipment/Facilities
About us
Publications

Publications

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 144-159, 2023.

DOI for Physiologically based biopharmaceutics modeling of regional and colon absorption in humans
Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

DOI for Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue Download full text (pdf) of Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Open access
Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

Part of Journal of Drug Delivery Science and Technology, 2019.

DOI for Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality Download full text (pdf) of Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Open access
Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Dubbelboer, Ilse R; Barmpatsalou, Vicky; Rodler, Agnes; Karlsson, Eva et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 92-102, 2022.

DOI for Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties
Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Barmpatsalou, Vicky; Dubbelboer, Ilse R; Rodler, Agnes; Jacobson, Magdalena et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 156-167, 2021.

DOI for Physiological properties, composition and structural profiling of porcine gastrointestinal mucus Download full text (pdf) of Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Open access
Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Karlsson, Oskar; Svanholm, Sofie; Eriksson, Andreas; Chidiac, Joseph et al.

Part of Science of the Total Environment, 2021.

DOI for Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Open access
Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

O'Shea, Joseph P.; Augustijns, Patrick; Brandl, Martin; Brayden, David J. et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

DOI for Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review Download full text (pdf) of Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

Open access
Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats Download full text (pdf) of Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Open access
Single bead investigation of a clinical drug delivery system – a novel release mechanism

Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

Part of Journal of Controlled Release, p. 235-247, 2018.

DOI for Single bead investigation of a clinical drug delivery system – a novel release mechanism Download full text (pdf) of Single bead investigation of a clinical drug delivery system – a novel release mechanism

Open access
Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 274-281, 2017.

DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system Download full text (pdf) of Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Open access
Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats Download full text (pdf) of Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Open access
Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022.

DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Open access
Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Sjögren, Erik; Bredberg, Ulf; Allard, Erik; Arvidsson, Björn et al.

Part of Pharmaceutical research, p. 597-607, 2010.

DOI for Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model
The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Bergman, Ebba; Lundahl, Anna; Fridblom, Patrik; Hedeland, Mikael et al.

Part of Drug Metabolism And Disposition, p. 2349-2358, 2009.

DOI for The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil
Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Bergman, Ebba; Matsson, Elin M; Hedeland, Mikael; Bondesson, Ulf et al.

Part of Journal of clinical pharmacology, p. 1039-1049, 2010.

DOI for Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers
The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Bergman, Ebba; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Part of Xenobiotica, p. 558-568, 2010.

DOI for The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo
Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

Thörn, Helena Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Part of Drug Metabolism And Disposition, p. 2186-2196, 2009.

DOI for Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions
Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Lundahl, Anna; Lennernäs, Hans; Knutson, Lars; Bondesson, Ulf et al.

Part of Drug Metabolism And Disposition, p. 2008-2017, 2009.

DOI for Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography

Knutson, Tina; Fridblom, Patrik; Ahlström, Håkan; Magnusson, Anders et al.

Part of Molecular pharmaceutics, p. 2-10, 2009.

DOI for Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography
Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study

Johannsson, Gudmundur; Bergthorsdottir, Ragnhildur; Nilsson, Anna G; Lennernäs, Hans et al.

Part of European Journal of Endocrinology, p. 119-130, 2009.

DOI for Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study
Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide

Gram, Luise K; Rist, Gerda Marie; Lennernäs, Hans; Steffansen, Bente

Part of European Journal of Pharmaceutical Sciences, p. 378-386, 2009.

DOI for Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide
Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations

Lennernäs, Hans

Part of Molecular pharmaceutics, p. 1429-1440, 2009.

DOI for Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations
Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy

Amidon, K. S.; Langguth, P.; Lennernäs, Hans; Yu, L. et al.

Part of Clinical Pharmacology and Therapeutics, p. 467-470, 2011.

DOI for Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy
Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

Thörn, Helena Anna; Sjögren, Erik; Dickinson, Paul Alfred; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 3034-3045, 2012.

DOI for Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

Thörn, Helena Anna; Lundahl, Anna; Schrickx, Johannes Antonius; Dickinson, Paul Alfred et al.

Part of European Journal of Pharmaceutical Sciences, p. 89-98, 2011.

DOI for Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

Last modified: 2022-10-24

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