Department of Pharmacy

Department of Pharmacy Research Biopharmaceutics Publications

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Publications

Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

Part of Applied Sciences, 2020.

DOI for Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations Download full text (pdf) of Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

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Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Part of AAPS Journal, 2020.

DOI for Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption Download full text (pdf) of Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

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Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

Olivares-Morales, Andres; Lennernäs, Hans; Aarons, Leon; Rostami-Hodjegan, Amin

Part of AAPS Journal, p. 1177-1192, 2015.

DOI for Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption
Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Part of AAPS Journal, 2018.

DOI for Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment Download full text (pdf) of Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

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Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report

Suarez-Sharp, Sandra; Cohen, Michael; Kesisoglou, Filippos; Abend, Andreas et al.

Part of AAPS Journal, 2018.

DOI for Applications of Clinically Relevant Dissolution Testing: Workshop Summary Report
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico et al.

Part of AAPS Journal, 2019.

DOI for Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report
Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Dahlgren, David; Lennernäs, Hans

Part of Molecules, 2020.

DOI for Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective Download full text (pdf) of Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023.

DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma Download full text (pdf) of Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

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Physiologically based biopharmaceutics modeling of regional and colon absorption in humans

Tannergren, Christer; Jadhav, Harshad; Eckernas, Emma; Fagerberg, Jonas et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 144-159, 2023.

DOI for Physiologically based biopharmaceutics modeling of regional and colon absorption in humans
Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

DOI for Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue Download full text (pdf) of Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

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Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

Part of Journal of Drug Delivery Science and Technology, 2019.

DOI for Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality Download full text (pdf) of Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

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Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Dubbelboer, Ilse R; Barmpatsalou, Vicky; Rodler, Agnes; Karlsson, Eva et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 92-102, 2022.

DOI for Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties
Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Barmpatsalou, Vicky; Dubbelboer, Ilse R; Rodler, Agnes; Jacobson, Magdalena et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 156-167, 2021.

DOI for Physiological properties, composition and structural profiling of porcine gastrointestinal mucus Download full text (pdf) of Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

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Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Karlsson, Oskar; Svanholm, Sofie; Eriksson, Andreas; Chidiac, Joseph et al.

Part of Science of the Total Environment, 2021.

DOI for Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Open access
Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

O'Shea, Joseph P.; Augustijns, Patrick; Brandl, Martin; Brayden, David J. et al.

Part of European Journal of Pharmaceutical Sciences, 2022.

DOI for Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review Download full text (pdf) of Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats Download full text (pdf) of Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

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Single bead investigation of a clinical drug delivery system – a novel release mechanism

Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

Part of Journal of Controlled Release, p. 235-247, 2018.

DOI for Single bead investigation of a clinical drug delivery system – a novel release mechanism Download full text (pdf) of Single bead investigation of a clinical drug delivery system – a novel release mechanism

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Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 274-281, 2017.

DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system Download full text (pdf) of Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats Download full text (pdf) of Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022.

DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Download full text (pdf) of Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

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Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Sjögren, Erik; Bredberg, Ulf; Allard, Erik; Arvidsson, Björn et al.

Part of Pharmaceutical research, p. 597-607, 2010.

DOI for Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model
The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Bergman, Ebba; Lundahl, Anna; Fridblom, Patrik; Hedeland, Mikael et al.

Part of Drug Metabolism And Disposition, p. 2349-2358, 2009.

DOI for The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil
Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Bergman, Ebba; Matsson, Elin M; Hedeland, Mikael; Bondesson, Ulf et al.

Part of Journal of clinical pharmacology, p. 1039-1049, 2010.

DOI for Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers
The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Bergman, Ebba; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Part of Xenobiotica, p. 558-568, 2010.

DOI for The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo
Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

Thörn, Helena Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Part of Drug Metabolism And Disposition, p. 2186-2196, 2009.

DOI for Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

Last modified: 2022-10-24