Selected publications

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Part of Alzheimer's Research & Therapy, 2023.

DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease Download full text (pdf) of Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Morrison, Jamie I.; Metzendorf, Nicole G.; Rofo, Fadi; Petrovic, Alex et al.

Part of Journal of Neurochemistry, p. 413-425, 2023.

DOI for A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses Download full text (pdf) of A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Part of Pharmaceutics, 2022.

DOI for Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody Download full text (pdf) of Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Part of NEUROTHERAPEUTICS, p. 1588-1602, 2022.

DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice Download full text (pdf) of A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Part of Alzheimer's Research & Therapy, 2022.

DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease Download full text (pdf) of Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Part of Neuropharmacology, 2022.

DOI for In vivo imaging of alpha-synuclein with antibody-based PET Download full text (pdf) of In vivo imaging of alpha-synuclein with antibody-based PET

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Part of Scientific Reports, 2022.

DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 Download full text (pdf) of Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Meier, Silvio R.; Sehlin, Dag; Hultqvist, Greta; Syvänen, Stina

Part of Molecular Imaging and Biology, 2021.

DOI for Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease Download full text (pdf) of Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells

Napoleone, Antonino; Laurén, Ida; Linkgreim, Triinu; Dahllund, Leif et al.

Part of New Biotechnology, p. 9-19, 2021.

DOI for Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells Download full text (pdf) of Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Part of Translational Neurodegeneration, 2021.

DOI for Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta Download full text (pdf) of Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Part of Theranostics, p. 789-804, 2021.

DOI for Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain Download full text (pdf) of Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Part of ACS Chemical Neuroscience, p. 2529-2541, 2021.

DOI for Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide Download full text (pdf) of Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta et al.

Part of The FASEB Journal, p. 13272-13283, 2020.

DOI for Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle. Download full text (pdf) of Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

Part of NeuroImage, p. 881-888, 2019.

DOI for High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta

Eriksson, Jonas; Fang, Xiaotian T.; Hultqvist, Greta; Olberg, D. E. et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. S643-S643, 2018.

Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Part of Alzheimer's Research & Therapy, 2018.

DOI for Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody Download full text (pdf) of Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Part of Journal of Nuclear Medicine, p. 1885-1891, 2018.

DOI for Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition Download full text (pdf) of Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Part of Neuropharmacology, p. 1-9, 2018.

DOI for Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy Download full text (pdf) of Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

Jemth, Per; Karlsson, Elin; Vogeli, Beat; Guzovsky, Brenda et al.

Part of Science Advances, 2018.

DOI for Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

Antibody-based PET radioligands for imaging of amyloid-beta protofibrils

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Falting, J. et al.

Part of Journal of Cerebral Blood Flow and Metabolism, p. 84-84, 2017.

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Part of Theranostics, p. 308-318, 2017.

DOI for Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor Download full text (pdf) of Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Part of NeuroImage, p. 55-63, 2017.

DOI for A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging Download full text (pdf) of A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Evolution of the p53-MDM2 pathway

Åberg, Emma; Saccoccia, Fulvio; Grabherr, Manfred; Ore, Wai Ying Josefin et al.

Part of BMC Evolutionary Biology, 2017.

DOI for Evolution of the p53-MDM2 pathway Download full text (pdf) of Evolution of the p53-MDM2 pathway

Emergence and evolution of an interaction between intrinsically disordered proteins

Hultqvist, Greta; Åberg, Emma; Camilloni, Carlo; Sundell, Gustav et al.

Part of eLIFE, 2017.

DOI for Emergence and evolution of an interaction between intrinsically disordered proteins Download full text (pdf) of Emergence and evolution of an interaction between intrinsically disordered proteins

Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Part of Journal of Cerebral Blood Flow and Metabolism, p. 415-416, 2017.

A small bispecific antibody-based construct based on bapineuzumab as a PET tracer for amyloid beta pathology in brain

Fang, Xiaotian; Hultqvist, Greta; Meier, Silvio; Sehlin, Dag et al.

Part of Meeting abstract, 2017.

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Part of Biological Procedures Online, 2017.

DOI for Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells Download full text (pdf) of Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain

Pedersen, Soren W.; Hultqvist, Greta; Stromgaard, Kristian; Jemth, Per

Part of PLOS ONE, p. e95619-, 2014.

DOI for The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain Download full text (pdf) of The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

Pedersen, Soren W.; Pedersen, Stine B.; Anker, Louise; Hultqvist, Greta et al.

Part of Nature Communications, p. 3215-, 2014.

DOI for Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations Download full text (pdf) of Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

Hultqvist, Greta

Protein Folding, Binding and Evolution: PDZ domains and paralemmins as model systems

2013.

Download full text (pdf) of Hultqvist, Greta

Energetic pathway sampling in a protein interaction domain

Hultqvist, Greta; Haq, Raza; Punekar, Avinash; Chi, Celestine et al.

Part of Structure, p. 1193-1202, 2013.

DOI for Energetic pathway sampling in a protein interaction domain Download full text (pdf) of Energetic pathway sampling in a protein interaction domain

Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations

Eildal, Jonas N. N.; Hultqvist, Greta; Balle, Thomas; Stuhr-Hansen, Nicolai et al.

Part of Journal of the American Chemical Society, p. 12998-13007, 2013.

DOI for Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations Download full text (pdf) of Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations

An expanded view of the protein folding landscape of PDZ domains

Hultqvist, Greta; Pedersen, Søren; Strømgaard, Kristian; Chi, Celestine et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 550-553, 2012.

DOI for An expanded view of the protein folding landscape of PDZ domains Download full text (pdf) of An expanded view of the protein folding landscape of PDZ domains

Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains

Haq, S. Raza; Chi, Celestine N.; Bach, Anders; Dogan, Jakob et al.

Part of Journal of the American Chemical Society, p. 599-605, 2012.

DOI for Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains Download full text (pdf) of Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains

Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Hultqvist, Greta; Punekar, Avinash; Morrone, Angela; Chi, Celestine et al.

Part of PLOS ONE, p. e50055-, 2012.

DOI for Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain Download full text (pdf) of Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions

Hultqvist, Greta; Ocampo Daza, Daniel; Larhammar, Dan; Kilimann, Manfred W.

Part of PLOS ONE, p. e41850-, 2012.

DOI for Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions Download full text (pdf) of Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions

Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site

Limbach, Christoph; Laue, Michael M.; Wang, Xiaolu; Hu, Bin et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. E392-E401, 2011.

DOI for Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

Wang, Xiaolu; Hu, Bin; Zieba, Agata; Neumann, Nicole G et al.

Part of Journal of Neuroscience, p. 12584-12596, 2009.

DOI for A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1