Selected publications
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
Part of Alzheimer's Research & Therapy, 2023.
DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease Download full text (pdf) of Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
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A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
Part of Journal of Neurochemistry, p. 413-425, 2023.
DOI for A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses Download full text (pdf) of A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
Part of Pharmaceutics, 2022.
DOI for Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody Download full text (pdf) of Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
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A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
Part of NEUROTHERAPEUTICS, p. 1588-1602, 2022.
DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice Download full text (pdf) of A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
Part of Alzheimer's Research & Therapy, 2022.
DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease Download full text (pdf) of Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
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Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
Part of Scientific Reports, 2022.
DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 Download full text (pdf) of Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
Part of Molecular Imaging and Biology, 2021.
DOI for Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease Download full text (pdf) of Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
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Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells
Part of New Biotechnology, p. 9-19, 2021.
DOI for Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells Download full text (pdf) of Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells
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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
Part of Translational Neurodegeneration, 2021.
DOI for Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta Download full text (pdf) of Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
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Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
Part of Theranostics, p. 789-804, 2021.
DOI for Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain Download full text (pdf) of Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
Part of ACS Chemical Neuroscience, p. 2529-2541, 2021.
DOI for Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide Download full text (pdf) of Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
Part of The FASEB Journal, p. 13272-13283, 2020.
DOI for Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle. Download full text (pdf) of Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
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[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. S643-S643, 2018.
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Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
Part of Alzheimer's Research & Therapy, 2018.
DOI for Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody Download full text (pdf) of Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
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Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Part of Journal of Nuclear Medicine, p. 1885-1891, 2018.
DOI for Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition Download full text (pdf) of Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
Part of Neuropharmacology, p. 1-9, 2018.
DOI for Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy Download full text (pdf) of Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
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Antibody-based PET radioligands for imaging of amyloid-beta protofibrils
Part of Journal of Cerebral Blood Flow and Metabolism, p. 84-84, 2017.
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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Part of Theranostics, p. 308-318, 2017.
DOI for Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor Download full text (pdf) of Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
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A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
Part of NeuroImage, p. 55-63, 2017.
DOI for A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging Download full text (pdf) of A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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Evolution of the p53-MDM2 pathway
Part of BMC Evolutionary Biology, 2017.
DOI for Evolution of the p53-MDM2 pathway Download full text (pdf) of Evolution of the p53-MDM2 pathway
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Emergence and evolution of an interaction between intrinsically disordered proteins
Part of eLIFE, 2017.
DOI for Emergence and evolution of an interaction between intrinsically disordered proteins Download full text (pdf) of Emergence and evolution of an interaction between intrinsically disordered proteins
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Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody
Part of Journal of Cerebral Blood Flow and Metabolism, p. 415-416, 2017.
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A small bispecific antibody-based construct based on bapineuzumab as a PET tracer for amyloid beta pathology in brain
Part of Meeting abstract, 2017.
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
Part of Biological Procedures Online, 2017.
DOI for Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells Download full text (pdf) of Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
Part of PLOS ONE, p. e95619-, 2014.
DOI for The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain Download full text (pdf) of The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
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Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
Part of Nature Communications, p. 3215-, 2014.
DOI for Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations Download full text (pdf) of Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
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Hultqvist, Greta
Protein Folding, Binding and Evolution: PDZ domains and paralemmins as model systems
2013.
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Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations
Part of Journal of the American Chemical Society, p. 12998-13007, 2013.
DOI for Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations Download full text (pdf) of Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations
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An expanded view of the protein folding landscape of PDZ domains
Part of Biochemical and Biophysical Research Communications - BBRC, p. 550-553, 2012.
DOI for An expanded view of the protein folding landscape of PDZ domains Download full text (pdf) of An expanded view of the protein folding landscape of PDZ domains
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Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains
Part of Journal of the American Chemical Society, p. 599-605, 2012.
DOI for Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains Download full text (pdf) of Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains
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Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
Part of PLOS ONE, p. e41850-, 2012.
DOI for Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions Download full text (pdf) of Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
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Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site
Part of Proceedings of the National Academy of Sciences of the United States of America, p. E392-E401, 2011.
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A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
Part of Journal of Neuroscience, p. 12584-12596, 2009.