Biopharmaceuticals
Protein design against neurodegenerative diseases and immunotherapy against cancer.
Biopharmaceuticals
Since the success with the production of recombinant insulin for treatment of diabetes, we have succeeded in the generation of chimeric antibodies, humanized antibodies and complete human antibodies that are able to treat a rapidly growing number of diseases. Phage display technology along with advanced recombinant protein strategies have advanced the field since early 2000.
Novel targets and protein designs are constantly evolving and novel strategies for drug delivery to improve efficacy and reduce toxicity is key to the future success. The protein and peptide drug groups headed by Associate senior lecturer Greta Hultqvist and Associate senior lecturer Sara Mangsbo center around protein/peptide drug therapeutics with a focus on utilizing passive and active immunotherapy approaches to treat diseases like Alzheimer and bladder cancer. Their work center around innovative strategies to improve protein drugs and advanced characterization of the biology behind the therapeutic efficacy achieved by the novel drug entity.
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Våra publikationer
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Mangsbo, Sara M
Whole protein or long peptides in therapeutic vaccination strategies, does it make a difference?
2023
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Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar; Julku, Ulrika; Chourlia, Aikaterini; Nilsson, Per; Andersson, Ken G.; Laudon, Hanna; Hultqvist, Greta; Syvänen, Stina; Sehlin, Dag
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
2023
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Nazir, Faisal Hayat; Wiberg, Anna; Müller, Malin; Mangsbo, Sara; Burman, Joachim
Antibodies from serum and CSF of multiple sclerosis patients bind to oligodendroglial and neuronal cell-lines
2023
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Kerzeli, Iliana Kyriaki; Kostakis, Alexandros; Türker, Polat; Malmström, Per-Uno; Hemdan, Tammer; Mezheyeuski, Artur; Ward, Douglas G.; Bryan, Richard T.; Segersten, Ulrika; Lord, Martin; Mangsbo, Sara
Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
2023
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Morrison, Jamie I.; Metzendorf, Nicole G.; Rofo, Fadi; Petrovic, Alex; Hultqvist, Greta
A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
2023
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Lauren, Ida; Havervall, Sebastian; Ng, Henry; Lord, Martin; Pettke, Aleksandra; Greilert-Norin, Nina; Gabrielsson, Lena; Chourlia, Aikaterini; Amoedo-Leite, Catarina; Josyula, Vijay S.; Eltahir, Mohamed; Kerzeli, Iliana Kyriaki; Falk, August J.; Hober, Jonathan; Christ, Wanda; Wiberg, Anna; Hedhammar, My; Tegel, Hanna; Burman, Joachim; Xu, Feifei; Pin, Elisa; Manberg, Anna; Klingstrom, Jonas; Christoffersson, Gustaf; Hober, Sophia; Nilsson, Peter; Phillipson, Mia; Donnes, Pierre; Lindsay, Robin; Thalin, Charlotte; Mangsbo, Sara
Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology
2022
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Marking, Ulrika; Havervall, Sebastian; Greilert-Norin, Nina; Ng, Henry; Blom, Kim; Nilsson, Peter; Phillipson, Mia; Hober, Sophia; Nilsson, Charlotta; Mangsbo, Sara; Christ, Wanda; Klingstrom, Jonas; Gordon, Max; Åberg, Mikael; Thalin, Charlotte
Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines
2022
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Ellingsen, Espen Basmo; Aamdal, Elin; Guren, Tormod; Lilleby, Wolfgang; Brunsvig, Paal F.; Mangsbo, Sara; Aamdal, Steinar; Hovig, Eivind; Mensali, Nadia; Gaudernack, Gustav; Inderberg, Else Marit
Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
2022
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Havervall, Sebastian; Ng, Henry; Jernbom Falk, August; Greilert-Norin, Nina; Månberg, Anna; Marking, Ulrika; Laurén, Ida; Gabrielsson, Lena; Salomonsson, Ann-Christin; Aguilera, Katherina; Kihlgren, Martha; Månsson, Maja; Rosell, Axel; Hellström, Cecilia; Andersson, Eni; Olofsson, Jennie; Skoglund, Lovisa; Yousef, Jamil; Pin, Elisa; Lord, Martin; Åberg, Mikael; Hedhammar, My; Tegel, Hanna; Dönnes, Pierre; Phillipson, Mia; Nilsson, Peter; Klingström, Jonas; Mangsbo, Sara; Hober, Sophia; Thålin, Charlotte
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19
2022
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Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas; Masliah, Eliezer; Hultqvist, Greta; Bergström, Joakim; Ingelsson, Martin; Syvänen, Stina; Sehlin, Dag
Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
2022
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Blom, Kim; Marking, Ulrika; Havervall, Sebastian; Norin, Nina Greilert; Gordon, Max; Garcia, Marina; Tecleab, Teghesti; Christ, Wanda; Forsell, Mattias; Phillipson, Mia; Nilsson, Peter; Mangsbo, Sara; Hober, Sophia; Åberg, Mikael; Klingström, Jonas; Thålin, Charlotte
Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection
2022
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Tolf, Andreas; Wiberg, Anna; Müller, Malin; Nazir, Faisal Hayat; Pavlovic, Ivan; Laurén, Ida; Mangsbo, Sara; Burman, Joachim
Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab
2022
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Ellingsen, Espen Basmo; Bounova, Gergana; Kerzeli, Iliana Kyriaki; Anzar, Irantzu; Simnica, Donjete; Aamdal, Elin; Guren, Tormod; Clancy, Trevor; Mezheyeuski, Artur; Inderberg, Else Marit; Mangsbo, Sara; Binder, Mascha; Hovig, Eivind; Gaudernack, Gustav
Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
2022
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Havervall, Sebastian; Marking, Ulrika; Greilert-Norin, Nina; Gordon, Max; Ng, Henry; Christ, Wanda; Phillipson, Mia; Nilsson, Peter; Hober, Sophia; Blom, Kim; Klingstrom, Jonas; Mangsbo, Sara; Åberg, Mikael; Thalin, Charlotte
Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time
2022
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Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie; Petrovic, Alex; Syvänen, Stina; Sehlin, Dag; Hultqvist, Greta
A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
2022
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Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura; Godec, Ana; Sehlin, Dag; Syvänen, Stina; Hultqvist, Greta
Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
2022
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Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda; Zachrisson, Olof; Meier, Silvio R.; Ekmark-Lewén, Sara; Bergström, Joakim; Ingelsson, Martin; Sehlin, Dag; Syvänen, Stina
In vivo imaging of alpha-synuclein with antibody-based PET
2022
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Havervall, Sebastian; Falk, August Jernbom; Klingstrom, Jonas; Ng, Henry; Greilert-Norin, Nina; Gabrielsson, Lena; Salomonsson, Ann-Christin; Isaksson, Eva; Rudberg, Ann-Sofie; Hellstrom, Cecilia; Andersson, Eni; Olofsson, Jennie; Skoglund, Lovisa; Yousef, Jamil; Pin, Elisa; Christ, Wanda; Olausson, Mikaela; Hedhammar, My; Tegel, Hanna; Mangsbo, Sara; Phillipson, Mia; Manberg, Anna; Hober, Sophia; Nilsson, Peter; Thalin, Charlotte
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection
2022
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Eltahir, Mohamed; Lauren, Ida; Lord, Martin; Chourlia, Aikaterini; Dahllund, Leif; Olsson, Anders; Saleh, Aljona; Ytterberg, A. Jimmy; Lindqvist, Annika; Andersson, Oskar; Persson, Helena; Mangsbo, Sara
An Adaptable Antibody-Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies
2022
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de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca; Rofo, Fadi; Petrovic, Alex; O'Callaghan, Paul; Syvänen, Stina; Hultqvist, Greta
Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
2022
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Eltahir, mohmo394; Fletcher, E.; Dynesius, L.; Jarblad, J. L.; Lord, Martin; Laurén, I.; Zekarias, M.; Yu, X.; Cragg, M. S.; Hammarström, C.; Levedahl, Kerstin; Höglund, Martin; Ullenhag, Gustav; Mattsson, M.; Mangsbo, Sara
Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients
2021
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Cuzzubbo, Stefania; Mangsbo, Sara; Nagarajan, Divya; Habra, Kinana; Pockley, Alan Graham; McArdle, Stephanie E. B.
Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments
2021
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Basmo Ellingsen, Espen; Mangsbo, Sara M.; Hovig, Eivind; Gaudernack, Gustav
Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
2021
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Havervall, Sebastian; Rosell, Axel; Phillipson, Mia; Mangsbo, Sara; Nilsson, Peter; Hober, Sophia; Thalin, Charlotte
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers
2021
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Napoleone, Antonino; Laurén, Ida; Linkgreim, Triinu; Dahllund, Leif; Persson, Helena; Andersson, Oskar; Olsson, Anders; Hultqvist, Greta; Frank, Peter; Hall, Martin; Morrison, Annika; Andersson, Andreas; Lord, Martin; Mangsbo, Sara
Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells
2021
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Havervall, Sebastian; Marking, Ulrika; Greilert-Norin, Nina; Ng, Henry; Gordon, Max; Salomonsson, Ann-Christin; Hellström, Cecilia; Pin, Elisa; Blom, Kim; Mangsbo, Sara; Phillipson, Mia; Klingström, Jonas; Hober, Sophia; Nilsson, Peter; Åberg, Mikael; Thålin, Charlotte
Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2
2021
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Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy; Chourlia, Aikaterini; Stepanek, Ivan; Larsson, Elinor; van Hooren, Luuk; Nelander, Sven; Malmström, Per-Uno; Dragomir, Anca; Segersten, Ulrika; Mangsbo, Sara
Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations
2021
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Mangsbo, Sara; Havervall, Sebastian; Laurén, Ida; Lindsay, Robin; Falk, August Jernbom; Marking, Ulrika; Lord, Martin; Buggert, Marcus; Dönnes, Pierre; Christoffersson, Gustaf; Nilsson, Peter; Hober, Sophia; Phillipson, Mia; Klingström, Jonas; Thålin, Charlotte
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses
2021
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Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken; Lannfelt, Lars; Lilja, Anna M.; Metzendorf, Nicole G.; Gustavsson, Tobias; Sehlin, Dag; Soderberg, Linda; Hultqvist, Greta
Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
2021
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Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias; Beretta, Chiara; Erlandsson, Anna; Sehlin, Dag; Syvänen, Stina; Nilsson, Per; Hultqvist, Greta
Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
2021
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Backman, Max; La Fleur, Linnea; Kurppa, Pinja; Djureinovic, Dijana; Elfving, Hedvig; Brunnström, Hans; Mattsson, Johanna Sofia Margareta; Lindberg, Amanda; Pontén, Victor; Eltahir, Mohamed; Mangsbo, Sara; Gulyas, Miklos; Isaksson, Johan; Jirström, Karin; Kärre, Klas; Leandersson, Karin; Mezheyeuski, Artur; Pontén, Fredrik; Strell, Carina; Lindskog, Cecilia; Botling, Johan; Micke, Patrick
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
2021
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Eltahir, Mohamed; Isaksson, Johan; Mattsson, Johanna Sofia Margareta; Karre, Klas; Botling, Johan; Lord, Martin; Mangsbo, Sara; Micke, Patrick
Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade
2021
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van Hooren, Luuk; Vaccaro, Alessandra; Ramachandran, Mohanraj; Vazaios, Konstantinos; Libard, Sylwia; van de Walle, Tiarne; Georganaki, Maria; Huang, Hua; Pietilä, Ilkka; Lau, Joey; Ulvmar, Maria H.; Karlsson, Mikael C. I.; Zetterling, Maria; Mangsbo, Sara M.; Jakola, Asgeir S.; Olsson Bontell, Thomas; Smits, Anja; Essand, Magnus; Dimberg, Anna
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
2021
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Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G.; Morrison, Jamie I.; Syvänen, Stina; Andrén, Per E.; Jansson, Erik T.; Hultqvist, Greta
Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
2021
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Georganaki, Maria; Ramachandran, Mohanraj; Tuit, Sander; Nunez, Nicolas Gonzalo; Karampatzakis, Alexandros; Fotaki, Grammatiki; van Hooren, Luuk; Huang, Hua; Lugano, Roberta; Ulas, Thomas; Kaunisto, Aura; Holland, Eric C.; Ellmark, Peter; Mangsbo, Sara; Schultze, Joachim; Essand, Magnus; Tugues, Sonia; Dimberg, Anna
Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
2020
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Rostedt Punga, Anna; Strömme, Maria; Alimohammadi, Mohammed; Eltahir, Mohammed; Eshraghi, Anita; Godås, Maria; Koyi, Hirsh; Mangsbo, Sara; Olsson, Ida; Svedberg, Ingela
Flodvåg av långtidssjuka covid-19-patienter väntar
2020
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Eltahir, Mohamed; Persson, Helena; Mangsbo, Sara
Tumor localized agonistic anti-CD40 therapy and beyond
2020
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Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta; Walsh, Frank S; Rutkowski, J Lynn; Syvänen, Stina
Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
2020
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Nasi, Aikaterini; McArdle, Stephanie; Gaudernack, Gustav; Westman, Gabriel; Melief, Cornelis; Rockberg, Johan; Arens, Ramon; Kouretas, Demetrios; Sjölin, Jan; Mangsbo, Sara
Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention
2020
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Ibarra, Cristian; Karlsson, Marie; Codeluppi, Simone; Varas-Godoy, Manuel; Zhang, Songbai; Louhivuori, Lauri; Mangsbo, Sara; Hosseini, Arad; Soltani, Navid; Kaba, Rahim; Lundgren, T. Kalle; Hosseini, Abolfazl; Tanaka, Nobuyuki; Oya, Mototsugu; Wiklund, Peter; Miyakawa, Ayako; Uhlen, Per
BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling
2019
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Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar; Sehlin, Dag; Syvänen, Stina
High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain
2019
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Mangsbo, Sara; Fletcher, Erika; van Maren, Wendy; Redeker, Anke; Cordfunke, Robert; Dillmann, Inken; Dinkelaar, Jasper; Ouchaou, Kahina; Codee, Jeroen; van der Marel, Gijs; Hoogerhout, Peter; Melief, Cornelis; Ossendorp, Ferry; Drijfhout, Jan Wouter
Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses
2018
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Fletcher, Erika; van Maren, Wendy; Cordfunke, Robert; Dinkelaar, Jasper; Codee, Jeroen D. C.; van der Marel, Gijs; Melief, Cornelis J. M.; Ossendorp, Ferry; Drijfhout, Jan Wouter; Mangsbo, Sara
Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System
2018
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Eriksson, Jonas; Fang, Xiaotian T.; Hultqvist, Greta; Olberg, D. E.; Antoni, Gunnar; Lannfelt, Lars; Sehlin, Dag; Syvänen, Stina
[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta
2018
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Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid; Laudon, Hanna; Söderberg, Linda; Ingelsson, Martin; Lannfelt, Lars; Sehlin, Dag
Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
2018
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Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T.; Roshanbin, Sahar; Lannfelt, Lars; Neumann, Ulf; Sehlin, Dag
Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
2018
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Fletcher, Erika A. K.; Eltahir, Mohamed; Lindqvist, Frida; Rieth, Jonas; Törnqvist, Gunilla; Leja-Jarblad, Justyna; Mangsbo, Sara
Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics
2018
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Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta; Hammarlund-Udenaes, Margareta; Sehlin, Dag; Syvänen, Stina
Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
2018
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Jemth, Per; Karlsson, Elin; Vogeli, Beat; Guzovsky, Brenda; Andersson, Eva; Hultqvist, Greta; Dogan, Jakob; Guntert, Peter; Riek, Roland; Chi, Celestine N.
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
2018
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Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Falting, J.; Antoni, Gunnar; Lannfelt, Lars; Sehlin, Dag
Antibody-based PET radioligands for imaging of amyloid-beta protofibrils
2017