Senaste publikationer

  • Andronis, Christos; Silva, João Pedro; Lekka, Eftychia; Virvilis, Vassilis et al.

    Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

    Ingår i Archives of Toxicology, s. 2829-2845, 2020.

    Open access
  • Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

    Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

    Ingår i Scientific Reports, 2019.

    Open access
  • Hu, Yang; Gaillard, Pieter J.; De lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta

    Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 197-204, 2019.

  • Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C. M.; Auriola, Seppo et al.

    Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

    Ingår i Molecular Pharmaceutics, s. 3261-3274, 2019.

  • Yusof, Siti R; Mohd Uzid, Mahathir; Teh, Eng-Huat; Hanapi, Nur Aziah et al.

    Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

    Ingår i Addiction Biology, s. 935-945, 2019.

    Open access
  • Sulku, Johanna; Jansson, Christer; Melhus, Håkan; Malinovschi, Andrei et al.

    A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

    Ingår i The International Journal of Chronic Obstructive Pulmonary Disease, s. 2451-2460, 2019.

    Open access
  • Hu, Yang; Hammarlund-Udenaes, Margareta; Fridén, Markus

    Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling.

    Ingår i Journal of Pharmaceutical Sciences, s. 3425-3433, 2019.

  • Mantas, Athanasios; Labbe, Valentine; Loryan, Irena; Mihranyan, Albert

    Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

    Ingår i Pharmaceutics, 2019.

    Open access
  • Gustafsson, Sofia; Lindström, Veronica; Ingelsson, Martin; Hammarlund-Udenaes, Margareta et al.

    Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

    Ingår i Neuropharmacology, s. 482-491, 2018.

    Open access
  • Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

    Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

    Ingår i European Journal of Pharmaceutical Sciences, s. 77-84, 2018.

  • Hu, Yang; Gaillard, Pieter J.; Rip, Jaap; De lange, Elizabeth C.M. et al.

    In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine

    Ingår i Molecular Pharmaceutics, s. 5493-5500, 2018.

  • Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

    Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

    Ingår i Neuropharmacology, s. 1-9, 2018.

    Open access
  • Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

    Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

    Ingår i European Journal of Pharmaceutical Sciences, s. 182-187, 2018.

  • Chen, Xiaomei; Keep, Richard F.; Liang, Yan; Zhu, Hao-Jie et al.

    Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

    Ingår i Biochemical Pharmacology, s. 89-97, 2017.

  • Chen, Xiaomei; Slättengren, Tim; de Lange, Elizabeth C. M.; Smith, David E. et al.

    Revisiting atenolol as a low passive permeability marker

    Ingår i Fluids and Barriers of the CNS, 2017.

    Open access
  • Loryan, Irena; Hoppe, Edmund; Hansen, Klaus; Held, Felix et al.

    Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

    Ingår i Molecular Pharmaceutics, s. 4362-4373, 2017.

  • Kusuhara, Hiroyuki; Obach, R. Scott; Rostami-Hodjegan, Amin; Pang, K. Sandy et al.

    Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

    Ingår i Journal of Pharmaceutical Sciences, s. 2188-2194, 2017.

  • Gustafsson, Sofia; Eriksson, Jonas; Syvänen, Stina; Eriksson, Olof et al.

    Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

    Ingår i NeuroImage, s. 177-186, 2017.

  • Hu, Yang; Rip, Jaap; Gaillard, Pieter J.; de lange, Elizabeth C. M. et al.

    The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study

    Ingår i Journal of Pharmaceutical Sciences, s. 2606-2613, 2017.

  • Bäckström, Erica; Lundqvist, Anders; Boger, Elin; Svanberg, Petter et al.

    Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

    Ingår i Journal of Pharmaceutical Sciences, s. 838-845, 2016.

  • Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

    In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

    Ingår i Molecular Psychiatry, s. 1527-1536, 2016.

  • Lindqvist, Annika; Rip, Jaap; van Kregten, Joan; Gaillard, Pieter J et al.

    In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes

    Ingår i Pharmaceutical research, s. 177-185, 2016.

  • Lindqvist, Annika; Jönsson, Siv; Hammarlund-Udenaes, Margareta

    Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

    Ingår i Molecular Pharmaceutics, s. 1258-1266, 2016.

  • Lindqvist, Annika; Fridén, Markus; Hammarlund-Udenaes, Margareta

    Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

    Ingår i European Journal of Pharmaceutical Sciences, s. 173-182, 2016.

  • Melander, Erik; Eriksson, Camilla; Jansson, Britt; Göransson, Ulf et al.

    Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

    Ingår i Biopolymers, s. 910-916, 2016.

    Open access
  • Bäckström, Erica; Boger, Elin; Lundqvist, Anders; Hammarlund-Udenaes, Margareta et al.

    Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

    Ingår i Journal of Pharmaceutical Sciences, s. 3432-3439, 2016.

  • Alassaad, Anna; Melhus, Håkan; Hammarlund-Udenaes, Margareta; Bertilsson, Maria et al.

    A tool for prediction of risk of rehospitalisation and mortality in the hospitalised elderly: secondary analysis of clinical trial data

    Ingår i BMJ Open, 2015.

    Open access
  • Loryan, Irena; Sinha, Vikash; Mackie, Claire; van Peer, Achiel et al.

    Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

    Ingår i Molecular Pharmaceutics, s. 520-532, 2015.

  • de Lange, E. C. M.; Hammarlund-Udenaes, Margareta

    Translational Aspects of Blood-Brain Barrier Transport and Central Nervous System Effects of Drugs: From Discovery to Patients

    Ingår i Clinical Pharmacology and Therapeutics, s. 380-394, 2015.

  • Sadiq, Muhammad Waqas; Uchida, Yasuo; Hoshi, Yutaro; Tachikawa, Masanori et al.

    Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

    Ingår i PLoS ONE, 2015.

    Open access
  • Alassaad, Anna; Bertilsson, Maria; Gillespie, Ulrika; Sundström, Johan et al.

    The effects of pharmacist intervention on emergency department visits in patients 80 years and older: subgroup analyses by number of prescribed drugs and appropriate prescribing

    Ingår i PLoS ONE, s. e111797-, 2014.

    Open access
  • Chen, Xiaomei; Loryan, Irena; Maryam, Payan; Keep, Richard F et al.

    Effect of transporter inhibitioin on the distribution of cefadroxil in rat brain

    Ingår i Fluids and Barriers of the CNS, s. 1-12, 2014.

    Open access
  • Chen, Xiaomei; Loryan, Irena; Payan, Maryam; Keep, Richard et al.

    Effect of transporter inhibition on the distribution of cefadroxil in rat brain

    Ingår i Fluids and Barriers of the CNS, 2014.

    Open access
  • Loryan, Irena; Vikash, Sinha; Claire, Mackie; Van Peer, Achiel et al.

    Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

    Ingår i Pharmaceutical research, s. 2203-2219, 2014.

  • Choong, Eva; Loryan, Irena; Lindqvist, Marja; Nordling, Åsa et al.

    Sex difference in formation of propofol metabolites: a replication study

    Ingår i Basic & Clinical Pharmacology & Toxicology, s. 126-131, 2013.

  • Gillespie, Ulrika; Alassaad, Anna; Hammarlund-Udenaes, Margareta; Morlin, Claes et al.

    Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization-Analyses from a Randomized Controlled Trial

    Ingår i PLoS ONE, s. e62401-, 2013.

    Open access
  • Marklund, Matti; Strömberg, Eric A; Hooker, Andrew C; Hammarlund-Udenaes, Margareta et al.

    Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats

    Ingår i Journal of Nutrition, s. 1573-1578, 2013.

  • Loryan, Irena; Friden, Markus; Hammarlund-Udenaes, Margareta

    The brain slice method for studying drug distribution in the CNS

    Ingår i Fluids and Barriers of the CNS, s. 6-, 2013.

    Open access
  • Hammarlund-Udenaes, Margareta; Brouwer, Kim; Nakashima, Emi; Terasaki, Tetsuya

    Perspectives on a pharmacokinetics legend: C versus T (contributions over time)

    Ingår i Journal of Pharmaceutical Sciences, s. 2889-2894, 2013.

  • Lindqvist, Annika; Rip, Jaap; Gaillard, Pieter J; Björkman, Sven et al.

    Enhanced Brain Delivery of the Opioid Peptide DAMGO in Glutathione PEGylated Liposomes: A Microdialysis Study

    Ingår i Molecular Pharmaceutics, s. 1533-1541, 2013.

  • Alassaad, Anna; Gillespie, Ulrika; Bertilsson, Maria; Melhus, Håkan et al.

    Prescription and transcription errors in multidose-dispensed medications on discharge from hospital: an observationaland interventional study

    Ingår i Journal of Evaluation In Clinical Practice, s. 185-191, 2013.

  • Sadiq, Muhammad Waqas; Boström, Emma; Keizer, Ron; Björkman, Sven et al.

    Oxymorphone active uptake at the blood-brain barrier and population modeling of its pharmacokinetic-pharmacodynamic relationship

    Ingår i Journal of Pharmaceutical Sciences, s. 3320-3331, 2013.

  • Loryan, Irena; Lindqvist, Marja; Johansson, Inger; Hiratsuka, Masahiro et al.

    Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

    Ingår i European Journal of Clinical Pharmacology, s. 397-406, 2012.

  • Haslemo, T; Loryan, Irena; Ueda, N; Mannheimer, B et al.

    UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems

    Ingår i Clinical Pharmacology and Therapeutics, s. 221-227, 2012.

  • Stevens, Jasper; Ploeger, Bart A.; Hammarlund-Udenaes, Margareta; Osswald, Gunilla et al.

    Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans

    Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 463-477, 2012.

  • Gillespie, Ulrika; Mörlin, Claes; Hammarlund-Udenaes, Margareta; Hedström, Mariann

    Perceived value of ward-based pharmacists from the perspective of physicians and nurses

    Ingår i International Journal of Clinical Pharmacy, s. 127-135, 2012.

  • Lindqvist, Annika; Jansson, Britt; Hammarlund-Udenaes, Margareta

    Quantitative analysis of the opioid peptide DAMGO in rat plasma and microdialysis samples using liquid chromatography-tandem mass spectrometry

    Ingår i Journal of chromatography. B, s. 11-17, 2012.

  • Sadiq, Muhammad Waqas; Salehpour, Mehran; Forsgård, Niklas; Possnert, Göran et al.

    Morphine brain pharmacokinetics at very low concentrations studied with Accelerator Mass Spectrometry and Liquid Chromatography-tandem Mass Spectrometry

    Ingår i Drug Metabolism And Disposition, s. 174-179, 2011.

  • Fridén, Markus; Bergström, Fredrik; Wan, Hong; Rehngren, Mikael et al.

    Measurement of Unbound Drug Exposure in Brain: Modelling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

    Ingår i Drug Metabolism And Disposition, s. 353-362, 2011.

  • Sadiq, Muhammad Waqas; Borgs, Annika; Okura, Takashi; Shimomura, Keita et al.

    Diphenhydramine Active Uptake at the Blood-Brain Barrier and Its Interaction with Oxycodone in Vitro and in Vivo

    Ingår i Journal of Pharmaceutical Sciences, s. 3912-3923, 2011.