Institutionen för farmaci

Institutionen för farmaci Forskning Farmakokinetik och farmakodynamik Translationell Farmakokinetik/farmakodynamik Publikationer

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Senaste publikationer

Brain barriers virtual: an interim solution or future opportunity?

Holder, Brianna M.; Tolan, Shaina E.; Heinrich, Kaleb K.; Miller, Kaitlin C. et al.

Ingår i Fluids and Barriers of the CNS, 2022.

DOI för Brain barriers virtual: an interim solution or future opportunity? Ladda ner fulltext (pdf) av Brain barriers virtual: an interim solution or future opportunity?

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Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure

Backstrom, E.; Erngren, T.; Fihn, B-M; Sadiq, M. W. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 852-858, 2022.

DOI för Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure
Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Ingår i Pharmaceutical research, s. 1283-1289, 2022.

DOI för Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics
Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Ingår i Pharmaceutical research, s. 1291-1296, 2022.

DOI för Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor
Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Ingår i Pharmaceutical research, s. 1321-1341, 2022.

DOI för Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development Ladda ner fulltext (pdf) av Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

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Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

de Lange, Elizabeth C. M.; Hammarlund-Udenaes, Margareta

Ingår i Clinical Pharmacology and Therapeutics, s. 758-773, 2022.

DOI för Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics Ladda ner fulltext (pdf) av Understanding the Blood-Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

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Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya et al.

Ingår i IEEE journal of biomedical and health informatics, s. 371-380, 2021.

DOI för Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images Ladda ner fulltext (pdf) av Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

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Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Sadiq, Muhammad Waqas; Holz, Olaf; Ellinghusen, Birthe D.; Faulenbach, Cornelia et al.

Ingår i British Journal of Pharmacology, s. 4440-4451, 2021.

DOI för Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Open access
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Ingår i Molecular Psychiatry, s. 7732-7745, 2021.

DOI för Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier. Ladda ner fulltext (pdf) av Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Open access
Brain Distribution of Drugs:: Pharmacokinetic Considerations

Loryan, Irena; Hammarlund-Udenaes, Margareta; Syvänen, Stina

Ingår i Handbook of Experimental Pharmacology, 2020.

DOI för Brain Distribution of Drugs:: Pharmacokinetic Considerations
In Vivo Studies of Drug BBB Transport:: Translational Challenges and the Role of Brain Imaging

Syvänen, Stina; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Handbook of Experimental Pharmacology, 2020.

DOI för In Vivo Studies of Drug BBB Transport:: Translational Challenges and the Role of Brain Imaging
Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

Nyman, Elin; Lindh, Maria; Lövfors, William; Simonsson, Christian et al.

Ingår i CPT, s. 707-717, 2020.

DOI för Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling Ladda ner fulltext (pdf) av Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

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Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Andronis, Christos; Silva, João Pedro; Lekka, Eftychia; Virvilis, Vassilis et al.

Ingår i Archives of Toxicology, s. 2829-2845, 2020.

DOI för Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis Ladda ner fulltext (pdf) av Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Open access
Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment

Hu, Yang; Hammarlund-Udenaes, Margareta

Ingår i Molecular Pharmaceutics, s. 4029-4039, 2020.

DOI för Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment Ladda ner fulltext (pdf) av Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment

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Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

Hamm, Gregory R.; Bäckström, Erica; Brülls, Mikael; Nilsson, Anna et al.

Ingår i Journal of Aerosol Medicine, s. 43-53, 2020.

DOI för Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging
A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Sulku, Johanna; Jansson, Christer; Melhus, Håkan; Malinovschi, Andrei et al.

Ingår i The International Journal of Chronic Obstructive Pulmonary Disease, s. 2451-2460, 2019.

DOI för A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden Ladda ner fulltext (pdf) av A Cross-Sectional Study Assessing Appropriateness Of Inhaled Corticosteroid Treatment In Primary And Secondary Care Patients With COPD In Sweden

Open access
Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Mantas, Athanasios; Labbe, Valentine; Loryan, Irena; Mihranyan, Albert

Ingår i Pharmaceutics, 2019.

DOI för Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility Ladda ner fulltext (pdf) av Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Open access
Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Colcloughl, Nicola; Chen, Kan; Johnstrom, Peter; Fridén, Markus et al.

Ingår i Drug Discovery Today, s. 1067-1073, 2019.

DOI för Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery
Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Ganguly, Koustav; Carlander, Ulrika; Garessus, Estella D. G.; Fridén, Markus et al.

Ingår i Critical reviews in toxicology, s. 160-173, 2019.

DOI för Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data Ladda ner fulltext (pdf) av Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Open access
Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Ingår i Scientific Reports, 2019.

DOI för Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development Ladda ner fulltext (pdf) av Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Open access
Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C. M.; Auriola, Seppo et al.

Ingår i Molecular Pharmaceutics, s. 3261-3274, 2019.

DOI för Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

Schou, Magnus; Ewing, Par; Cselenyi, Zsolt; Fridén, Markus et al.

Ingår i EJNMMI Research, 2019.

DOI för Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator Ladda ner fulltext (pdf) av Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

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Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Yusof, Siti R; Mohd Uzid, Mahathir; Teh, Eng-Huat; Hanapi, Nur Aziah et al.

Ingår i Addiction Biology, s. 935-945, 2019.

DOI för Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Open access
Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?

Hu, Yang; Gaillard, Pieter J.; De lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 197-204, 2019.

DOI för Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?
Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling.

Hu, Yang; Hammarlund-Udenaes, Margareta; Fridén, Markus

Ingår i Journal of Pharmaceutical Sciences, s. 3425-3433, 2019.

DOI för Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling.
Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Ingår i Neuropharmacology, s. 1-9, 2018.

DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy Ladda ner fulltext (pdf) av Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

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In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine

Hu, Yang; Gaillard, Pieter J.; Rip, Jaap; De lange, Elizabeth C.M. et al.

Ingår i Molecular Pharmaceutics, s. 5493-5500, 2018.

DOI för In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine
Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

Gustafsson, Sofia; Lindström, Veronica; Ingelsson, Martin; Hammarlund-Udenaes, Margareta et al.

Ingår i Neuropharmacology, s. 482-491, 2018.

DOI för Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology Ladda ner fulltext (pdf) av Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

Open access
Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 77-84, 2018.

DOI för Pharmacokinetics of Pericyte Involvement in Small-Molecular Drug Transport Across the Blood-Brain Barrier
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Boger, Elin; Fridén, Markus

Ingår i Journal of Aerosol Medicine, s. 1-12, 2018.

DOI för Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms
Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State

Mihajlica, Nebojsa; Betsholtz, Christer; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 182-187, 2018.

DOI för Rate of Small-Molecular Drug Transport Across the Blood-Brain Barrier in a Pericyte-Deficient State
Uncovering the regional localization of inhaled salmeterol retention in the lung

Bäckström, Erica; Hamm, Gregory; Nilsson, Anna; Fihn, Britt-Marie et al.

Ingår i Drug Delivery, s. 838-845, 2018.

DOI för Uncovering the regional localization of inhaled salmeterol retention in the lung Ladda ner fulltext (pdf) av Uncovering the regional localization of inhaled salmeterol retention in the lung

Open access
Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Ericsson, Therese; Fridén, Markus; Kärrman-Mårdh, Carina; Dainty, Ian et al.

Ingår i Pharmaceutical research, s. 2557-2567, 2017.

DOI för Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data
Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Gustafsson, Sofia; Eriksson, Jonas; Syvänen, Stina; Eriksson, Olof et al.

Ingår i NeuroImage, s. 177-186, 2017.

DOI för Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations
Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

Ehrhardt, Carsten; Backman, Per; Couet, William; Edwards, Chris et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2234-2244, 2017.

DOI för Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

Greenwood, John; Hammarlund-Udenaes, Margareta; Jones, Hazel C.; Stitt, Alan W. et al.

Ingår i Fluids and Barriers of the CNS, 2017.

DOI för Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017 Ladda ner fulltext (pdf) av Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

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Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study

Chen, Xiaomei; Keep, Richard F.; Liang, Yan; Zhu, Hao-Jie et al.

Ingår i Biochemical Pharmacology, s. 89-97, 2017.

DOI för Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study
Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review

Hammarlund-Udenaes, Margareta

Ingår i AAPS Journal, s. 1294-1303, 2017.

DOI för Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review Ladda ner fulltext (pdf) av Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review

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Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist

Kusuhara, Hiroyuki; Obach, R. Scott; Rostami-Hodjegan, Amin; Pang, K. Sandy et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2188-2194, 2017.

DOI för Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist
Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Loryan, Irena; Hoppe, Edmund; Hansen, Klaus; Held, Felix et al.

Ingår i Molecular Pharmaceutics, s. 4362-4373, 2017.

DOI för Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development
Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

Agrawal, Mukta; Ajazuddin, A; Tripathi, Dulal K.; Saraf, Swarnlata et al.

Ingår i Journal of Controlled Release, s. 61-77, 2017.

DOI för Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease
Revisiting atenolol as a low passive permeability marker

Chen, Xiaomei; Slättengren, Tim; de Lange, Elizabeth C. M.; Smith, David E. et al.

Ingår i Fluids and Barriers of the CNS, 2017.

DOI för Revisiting atenolol as a low passive permeability marker Ladda ner fulltext (pdf) av Revisiting atenolol as a low passive permeability marker

Open access
The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study

Hu, Yang; Rip, Jaap; Gaillard, Pieter J.; de lange, Elizabeth C. M. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2606-2613, 2017.

DOI för The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study
Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Bäckström, Erica; Lundqvist, Anders; Boger, Elin; Svanberg, Petter et al.

Ingår i Journal of Pharmaceutical Sciences, s. 838-845, 2016.

DOI för Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds
Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling

Lindqvist, Annika; Jönsson, Siv; Hammarlund-Udenaes, Margareta

Ingår i Molecular Pharmaceutics, s. 1258-1266, 2016.

DOI för Exploring Factors Causing Low Brain penetration of the Opioid Peptide DAMGO through Experimental Methods and Modeling
Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

Melander, Erik; Eriksson, Camilla; Jansson, Britt; Göransson, Ulf et al.

Ingår i Biopolymers, s. 910-916, 2016.

DOI för Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate Ladda ner fulltext (pdf) av Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate

Open access
In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes

Lindqvist, Annika; Rip, Jaap; van Kregten, Joan; Gaillard, Pieter J et al.

Ingår i Pharmaceutical research, s. 177-185, 2016.

DOI för In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes
In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Ingår i Molecular Psychiatry, s. 1527-1536, 2016.

DOI för In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy
Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Bäckström, Erica; Boger, Elin; Lundqvist, Anders; Hammarlund-Udenaes, Margareta et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3432-3439, 2016.

DOI för Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices
Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Lindqvist, Annika; Fridén, Markus; Hammarlund-Udenaes, Margareta

Ingår i European Journal of Pharmaceutical Sciences, s. 173-182, 2016.

DOI för Pharmacokinetic Considerations of Nanodelivery to the Brain: Using Modeling and Simulations to Predict Outcome of Liposomal Formulations

Senast uppdaterad: 2022-10-10