Publikationer 2016

50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Feeney, Orlagh M; Crum, Matthew F; McEvoy, Claire L; Trevaskis, Natalie L et al.

Ingår i Advanced Drug Delivery Reviews, s. 167-194, 2016.

DOI för 50 years of oral lipid-based formulations: Provenance, progress and future perspectives

A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Schowen, Katharine Barbara; Schowen, Richard L.; Borchardt, Susan E.; Borchardt, Paul M. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 370-385, 2016.

DOI för A Tribute to Ronald T. Borchardt-Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, Shanti; Nylander, Erik; Grönbladh, Alfhild; Vanga, Sudarsana Reddy et al.

Ingår i ACS Chemical Neuroscience, s. 1383-1392, 2016.

DOI för Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Almqvist, Helena; Axelsson, Hanna; Jafari, Rozbeh; Dan, Chen et al.

Ingår i Nature Communications, 2016.

DOI för CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil Ladda ner fulltext (pdf) av CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil

Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance

Vildhede, Anna; Wisniewski, Jacek; Norén, Agneta; Karlgren, Maria et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 96-96, 2016.

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Ingår i Journal of Pharmaceutical Sciences, s. 1017-1021, 2016.

DOI för Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Alhalaweh, Amjad; Bergström, Christel A. S.; Taylor, Lynne S.

Ingår i Journal of Controlled Release, s. 172-182, 2016.

DOI för Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergström, Christel A. S.; Charman, William N; Porter, Christopher J H

Ingår i Advanced Drug Delivery Reviews, s. 6-21, 2016.

DOI för Computational prediction of formulation strategies for beyond-rule-of-5 compounds Ladda ner fulltext (pdf) av Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Development of MS- based immunoassays for Cytochrome P450 and transporter quantification

Hammer, H. S.; Poetz, O.; Artursson, Per; Wegler, Christine

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. S47-S47, 2016.

Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Forsgren, Johan; Bergström, Christel et al.

Ingår i Journal of Pharmaceutical Sciences, s. 657-663, 2016.

DOI för Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Gordon, Laurie J; Allen, Morven; Artursson, Per; Hann, Michael M. et al.

Ingår i Journal of Biomolecular Screening, s. 156-164, 2016.

DOI för Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez, Sabin; Höglund, Andreas; Jacques, Sylvain A.; Johanson, Lars et al.

Ingår i Journal of Medicinal Chemistry, s. 1140-1148, 2016.

DOI för Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Urdzik, Jozef; Vildhede, Anna; Wiśniewski, Jacek R.; Duraj, Frans et al.

Ingår i PROTEOMES, 2016.

DOI för Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases Ladda ner fulltext (pdf) av Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases

Impact of drug transporters on intracellular unbound drug concentrations

Mateus, André; Treyer, Andrea; Matsson, Par; Karlgren, Maria et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 147-147, 2016.

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

Wisniewski, Jacek R.; Vildhede, Anna; Norén, Agneta; Artursson, Per

Ingår i Journal of Proteomics, s. 234-247, 2016.

DOI för In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes Ladda ner fulltext (pdf) av In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Andersson, Sara B. E.; Alvebratt, Caroline; Bevernage, Jan; Bonneau, Damien et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2864-2872, 2016.

DOI för Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Lipophilicity in Drug Development: Too Much or Not Enough?

Bergström, Christel A. S.; Yazdanian, Mehran

Ingår i AAPS Journal, s. 1095-1100, 2016.

DOI för Lipophilicity in Drug Development: Too Much or Not Enough?

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 56-57, 2016.

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Ingår i Drug Metabolism And Disposition, s. 505-516, 2016.

DOI för Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

New cell-based approaches for better predictions of drug transport and cellular drug exposure

Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 7-7, 2016.

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Lundquist, Patrik; Artursson, Per

Ingår i Advanced Drug Delivery Reviews, s. 256-276, 2016.

DOI för Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues Ladda ner fulltext (pdf) av Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Holmboe, Michael; Larsson, Per; Anwar, Jamshed; Bergström, Christel

Ingår i Langmuir, s. 12732-12740, 2016.

DOI för Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations Ladda ner fulltext (pdf) av Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Protein quantification of human hepatic drug transporters and metabolizing enzymes: an inter-laboratory and methodological comparison

Wegler, Christine; Gaugaz, Fabienne Z.; Andersson, Tommy B.; Wisniewski, Jacek R. et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 98-98, 2016.

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Gautschi, Nicolas; Bergström, Christel; Kuentz, Martin

Ingår i International Journal of Pharmaceutics, s. 164-174, 2016.

DOI för Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn; Matsson, Pär; Tyrchan, Christian; Artursson, Per et al.

Ingår i Nature Chemical Biology, s. 1065-+, 2016.

DOI för Structural and conformational determinants of macrocycle cell permeability

Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Ingår i Analytical Biochemistry, s. 82-88, 2016.

DOI för Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions Ladda ner fulltext (pdf) av Subcellular fractionation of human liver reveals limits in global proteomic quantification from isolated fractions

Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Welch, Ken; Bergström, Christel et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 468-474, 2016.

DOI för Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

The Need for Speed-Kinetic Limits of Drug Transporters

Matsson, Pär X.; Lundquist, Patrik; Artursson, Per

Ingår i TIPS - Trends in Pharmacological Sciences, s. 243-245, 2016.

DOI för The Need for Speed-Kinetic Limits of Drug Transporters

The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

Miyake, Masateru; Ragnarsson, Eva; Nakai, Daisuke; Artursson, Per

Ingår i Journal of Pharmaceutical Sciences, s. 2099-2104, 2016.

DOI för The Pro-inflammatory Cytokine Interleukin-6 Regulates Nanoparticle Transport Across Model Follicle-Associated Epithelium Cells

The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Ölander, Magnus; Wiśniewski, Jacek R.; Matsson, Pär; Lundquist, Patrik et al.

Ingår i Journal of Pharmaceutical Sciences, s. 817-827, 2016.

DOI för The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Good, James A. D.; Silver, Jim; Nunez-Otero, Carlos; Bahnan, Wael et al.

Ingår i Journal of Medicinal Chemistry, s. 2094-2108, 2016.

DOI för Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

To attach or not to attach: factors behind variable adhesion properties of cryopreserved human hepatocytes

Ölander, Magnus; Wisniewski, Jacek; Norén, Agneta; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 103-103, 2016.

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Alskär, Linda C.; Porter, Christopher J. H.; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 251-261, 2016.

DOI för Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Bergström, Christel A. S.; Porter, Christopher J. H.

Ingår i Advanced Drug Delivery Reviews, s. 1-5, 2016.

DOI för Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Validation and development of MTH1 inhibitors for treatment of cancer

Berglund, U. Warpman; Sanjiv, K.; Gad, H.; Kalderen, C. et al.

Ingår i Annals of Oncology, s. 2275-2283, 2016.

DOI för Validation and development of MTH1 inhibitors for treatment of cancer Ladda ner fulltext (pdf) av Validation and development of MTH1 inhibitors for treatment of cancer