Publikationer 2015 och tidigare

Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Matsson, Pär; Fenu, Luca A.; Lundquist, Patrik; Wisniewski, Jacek R. et al.

Ingår i TIPS - Trends in Pharmacological Sciences, s. 559-559, 2015.

DOI för Addendum to 'Quantifying the impact of transporters on cellular drug permeability'

Breaking the intestinal barrier to deliver drugs

Artursson, Per; Knight, Stefan

Ingår i Science, s. 716-717, 2015.

DOI för Breaking the intestinal barrier to deliver drugs

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Vildhede, Anna; Wisniewski, Jacek R.; Noren, Agneta; Karlgren, Maria et al.

Ingår i Journal of Proteome Research, s. 3305-3314, 2015.

DOI för Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Computational modeling to predict the functions and impact of drug transporters

Matsson, Pär; Bergström, Christel A S

Ingår i In silico pharmacology, 2015.

DOI för Computational modeling to predict the functions and impact of drug transporters Ladda ner fulltext (pdf) av Computational modeling to predict the functions and impact of drug transporters

Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Fagerberg, Jonas H.; Karlsson, Eva; Ulander, Johan; Hanisch, Gunilla et al.

Ingår i Pharmaceutical research, s. 578-589, 2015.

DOI för Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid Ladda ner fulltext (pdf) av Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Ingår i European Journal of Pharmaceutical Sciences, s. 12-20, 2015.

DOI för Concomitant intake of alcohol may increase the absorption of poorly soluble drugs Ladda ner fulltext (pdf) av Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance

Karlgren, Maria; Vildhede, Anna; Ölander, Magnus; Wisniewski, Jacek et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 245-246, 2015.

Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Fagerberg, Jonas H; Bergström, Christel A S

Ingår i Therapeutic delivery, s. 935-959, 2015.

DOI för Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Persson, Linda C.; Bergström, Christel A S

Ingår i Current molecular biology reports, s. 141-147, 2015.

DOI för Models for Predicting Drug Absorption From Oral Lipid-Based Formulations Ladda ner fulltext (pdf) av Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Alhalaweh, Amjad; Alzghoul, Ahmad; Mahlin, Denny; Bergström, Christel A. S.

Ingår i International Journal of Pharmaceutics, s. 312-317, 2015.

DOI för Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Ladda ner fulltext (pdf) av Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Borhade, Sanjay R.; Svensson, Richard; Brandt, Peter; Artursson, Per et al.

Ingår i ChemMedChem, s. 455-460, 2015.

DOI för Preclinical Characterization of Acyl Sulfonimidamides: Potential Carboxylic Acid Bioisosteres with Tunable Properties

Quantifying the impact of transporters on cellular drug permeability.

Matsson, Pär; Fenu, Luca A; Lundquist, Patrik; Wiśniewski, Jacek R et al.

Ingår i TIPS - Trends in Pharmacological Sciences, s. 255-262, 2015.

DOI för Quantifying the impact of transporters on cellular drug permeability. Ladda ner fulltext (pdf) av Quantifying the impact of transporters on cellular drug permeability.

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; Ericsson, Madelene et al.

Ingår i European Journal of Medicinal Chemistry, s. 191-209, 2015.

DOI för Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Mateus, André; Matsson, Pär; Artursson, Per

Ingår i Journal of Medicinal Chemistry, s. 3005-3010, 2014.

DOI för A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014.

DOI för Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Alhalaweh, Amjad; Alzghoul, Ahmad; Kaialy, Waseem; Mahlin, Denny et al.

Ingår i Molecular Pharmaceutics, s. 3123-3132, 2014.

DOI för Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 173-199, 2014.

DOI för Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Alzghoul, Ahmad; Alhalaweh, Amjad; Mahlin, Denny; Bergström, Christel A. S.

Ingår i JOURNAL OF CHEMICAL INFORMATION AND MODELING, s. 3396-3403, 2014.

DOI för Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna et al.

Ingår i ACS Medicinal Chemistry Letters, s. 1272-1277, 2014.

DOI för Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues

Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pedersen, Christian; Slepenkin, Anatoly; Andersson, Sara B. E.; Fagerberg, Jonas H. et al.

Ingår i PLOS ONE, s. e110918-, 2014.

DOI för Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis Ladda ner fulltext (pdf) av Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede, Anna; Karlgren, Maria; Svedberg, Elin K.; Wisniewski, Jacek R. et al.

Ingår i Drug Metabolism And Disposition, s. 1210-1218, 2014.

DOI för Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Over, Bjorn; McCarren, Patrick; Artursson, Per; Foley, Michael et al.

Ingår i Journal of Medicinal Chemistry, s. 2746-2754, 2014.

DOI för Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Is the full potential of the biopharmaceutics classification system reached?

Bergström, Christel A. S.; Andersson, Sara B. E.; Fagerberg, Jonas H.; Ragnarsson, Gert et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 224-231, 2014.

DOI för Is the full potential of the biopharmaceutics classification system reached?

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Gad, Helge; Koolmeister, Tobias; Jemth, Ann-Sofie; Eshtad, Saeed et al.

Ingår i Nature, s. 215-221, 2014.

DOI för MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014.

DOI för Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis; Artursson, Per; Avdeef, Alex; Di, Li et al.

Ingår i Molecular Pharmaceutics, s. 1727-1738, 2014.

DOI för Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna et al.

Ingår i Journal of Medicinal Chemistry, s. 6393-6402, 2014.

DOI för Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014.

DOI för Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

Kitambi, Satish Srinivas; Toledo, Enrique M.; Usoskin, Dmitry; Wee, Shimei et al.

Ingår i Cell, s. 313-328, 2014.

DOI för Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve, Etienne P. A.; Artursson, Per; Ingelman-Sundberg, Magnus; Karlgren, Maria

Ingår i Molecular Pharmaceutics, s. 3152-3163, 2013.

DOI för An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Ohrvik, Helena; Tydén, Eva; Artursson, Per; Oskarsson, Agneta et al.

Ingår i ISRN Toxicology, 2013.

DOI för Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Ingår i Molecular Pharmaceutics, s. 4252-4262, 2013.

DOI för Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Persson, Linda C.; Porter, Christopher J. H.; Charman, William N.; Bergström, Christel A. S.

Ingår i Pharmaceutical research, s. 3225-3237, 2013.

DOI för Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Ladda ner fulltext (pdf) av Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Computational Prospecting for Drug-Transporter Interactions

Matsson, Pär; Artursson, Per

Ingår i Clinical Pharmacology and Therapeutics, s. 30-32, 2013.

DOI för Computational Prospecting for Drug-Transporter Interactions

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Ingår i Journal of Medicinal Chemistry, s. 4953-4965, 2013.

DOI för Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Early drug development predictions of glass-forming ability and physical stability of drugs

Mahlin, Denny; Bergström, Christel A. S.

Ingår i European Journal of Pharmaceutical Sciences, s. 323-332, 2013.

DOI för Early drug development predictions of glass-forming ability and physical stability of drugs Ladda ner fulltext (pdf) av Early drug development predictions of glass-forming ability and physical stability of drugs

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Ingår i Toxicological Sciences, s. 328-343, 2013.

DOI för Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Ladda ner fulltext (pdf) av Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Early recognition of absorption challenges of contemporary targets:: key molecular properties and in silico tools

Bergström, Christel A S

Ingår i Bulletin Technique Gattefossé, s. 50-57, 2013.

Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Warren, Dallas B.; Bergström, Christel A. S.; Benameur, Hassan; Porter, Christopher J. H. et al.

Ingår i Molecular Pharmaceutics, s. 2823-2848, 2013.

DOI för Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Ingår i Journal of Medicinal Chemistry, s. 2690-2694, 2013.

DOI för Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Johansson, Carl-Christer; Gennemark, Peter; Artursson, Per; Abelo, Angela et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 117-128, 2013.

DOI för Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Rapid Measurement of Intracellular Unbound Drug Concentrations

Mateus, André; Matsson, Pär; Artursson, Per

Ingår i Molecular Pharmaceutics, s. 2467-2478, 2013.

DOI för Rapid Measurement of Intracellular Unbound Drug Concentrations

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B. et al.

Ingår i Toxicology in Vitro, s. 1357-1376, 2013.

DOI för The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Caco-2 monolayers in experimental and theoretical predictions of drug transport

Artursson, Per; Palm, Katrin; Luthman, Kristina

Ingår i Advanced Drug Delivery Reviews, s. 280-289, 2012.

DOI för Caco-2 monolayers in experimental and theoretical predictions of drug transport

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Karlgren, Maria; Vildhede, Anna; Norinder, Ulf; Wisniewski, Jacek R. et al.

Ingår i Journal of Medicinal Chemistry, s. 4740-4763, 2012.

DOI för Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Bergstrom, Christel A. S.; Charman, Susan A.; Nicolazzo, Joseph A.

Ingår i Pharmaceutical research, s. 3131-3142, 2012.

DOI för Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Fagerberg, Jonas H.; Al-Tikriti, Yassir; Ragnarsson, Gert; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 1942-1952, 2012.

DOI för Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F. et al.

Ingår i Drug Discovery Today, s. 905-912, 2012.

DOI för Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Ingår i Pharmaceutical research, s. 411-426, 2012.

DOI för In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

mRNA expression of drug-transporting proteins along the human intestine and comparison with expression in Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Lazorova, Lucia et al.

2012.

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions

Ahlin, Gustav; Chen, L; Lazorova, Lucia; Chen, Ying et al.

Ingår i The Pharmacogenomics Journal, s. 400-411, 2011.

DOI för Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3763-3772, 2011.

DOI för Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Mahlin, Denny; Ponnambalam, Sopana; Hockerfelt, Mina Heidarian; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 498-506, 2011.

DOI för Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Ingår i Molecular pharmaceutics, s. 1478-1487, 2010.

DOI för A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex et al.

Ingår i Nature reviews. Drug discovery, s. 597-614, 2010.

DOI för Coexistence of passive and carrier-mediated processes in drug transport

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H.; Tsinman, Oksana; Sun, Na; Tsinman, Konstantin et al.

Ingår i Molecular pharmaceutics, s. 1419-1430, 2010.

DOI för Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Bose, Partha Pratim; Chatterjee, Urmimala; Hubatsch, Ina; Artursson, Per et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 5896-5902, 2010.

DOI för In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 306-307, 2010.

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 304-305, 2010.

Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Strand, Sabina P; Lelu, Sylvie; Reitan, Nina K; de Lange Davies, Catharina et al.

Ingår i Biomaterials, s. 975-987, 2010.

DOI för Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking

Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Linnankoski, Johanna; Mäkelä, Johanna; Palmgren, Joni; Mauriala, Timo et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2166-2175, 2010.

DOI för Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)

Karlgren, Maria; Ahlin, Gustav; Vildhede, Anna; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 305-306, 2010.

Uptake mechanism of ochratoxin A and citrinin through human liver

Gao, Ge; Karlgren, Maria; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 315-315, 2010.

Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Ahlin, Gustav; Hilgendorf, Constanze; Karlsson, Johan; Al-Khalili Szigyarto, Cristina et al.

Ingår i Drug Metabolism And Disposition, s. 2275-2283, 2009.

DOI för Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 556-563, 2009.

DOI för Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Ingår i Pharmaceutical research, s. 1816-1831, 2009.

DOI för Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Hayeshi, Rose; Hilgendorf, Constanze; Artursson, Per; Augustijns, Patrick et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 383-396, 2008.

DOI för Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Ingår i Journal of Medicinal Chemistry, s. 3035-3039, 2008.

DOI för Molecular characteristics for solid-state limited solubility

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Ingår i Journal of Medicinal Chemistry, s. 3275-3287, 2008.

DOI för Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Ingår i Journal of Medicinal Chemistry, s. 5932-5942, 2008.

DOI för Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Strand, Sabina P; Issa, Mohamed M; Christensen, Bjørn E; Vårum, Kjell M et al.

Ingår i Biomacromolecules, s. 3268-76, 2008.

DOI för Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties

Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

Ragnarsson, Eva G E; Schoultz, Ida; Gullberg, Elisabet; Carlsson, Anders H et al.

Ingår i Laboratory investigation; a journal of technical methods and pathology, s. 1215-26, 2008.

DOI för Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 19-30, 2007.

DOI för A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers

Neuhoff, Sibylle; Artursson, Per; Ungell, Anna-Lena

Ingår i Journal of drug delivery science and technology, s. 259-266, 2007.

Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Hubatsch, Ina; Arvidsson, Per I.; Seebach, Dieter; Luthman, Kristina et al.

Ingår i Journal of Medicinal Chemistry, s. 5238-5242, 2007.

DOI för Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per

Ingår i Nature Protocols, s. 2111-2119, 2007.

DOI för Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Englund, Gunilla; Jacobson, Annica; Rorsman, Fredrik; Artursson, Per et al.

Ingår i Inflammatory Bowel Diseases, s. 291-297, 2007.

DOI för Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Hilgendorf, Constanze; Ahlin, Gustav; Seithel, Annick; Artursson, Per et al.

Ingår i Drug Metabolism And Disposition, s. 1333-1340, 2007.

DOI för Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Aziz, Emad F; Gråsjö, Johan; Forsberg, Johan; Andersson, Egil et al.

Ingår i Journal of Physical Chemistry A, s. 9662-9669, 2007.

DOI för Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Poorly soluble marketed drugs display solvation limited solubility

Bergström, Christel; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina

Ingår i Journal of Medicinal Chemistry, s. 5858-5862, 2007.

DOI för Poorly soluble marketed drugs display solvation limited solubility

Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.

Keita, Åsa V; Gullberg, Elisabet; Ericson, Ann-Charlott; Salim, Sa'ad Y et al.

Ingår i Lab Invest, s. 504-16, 2006.

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Ingår i Eur J Pharm Sci, s. 294-305, 2006.

Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Regnström, Karin; Ragnarsson, Eva GE; Fryknäs, Mårten; Köping-Höggård, Magnus et al.

Ingår i Pharmaceutical research, s. 475-482, 2006.

DOI för Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery

Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Gullberg, Elisabet; Keita, Åsa V.; Salim, Sa'ad Y.; Andersson, Margaretha et al.

Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 632-639, 2006.

DOI för Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches

Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.

Neuhoff, Sibylle; Artursson, Per; Zamora, Ismael; Ungell, Anna-Lena

Ingår i Pharm Res, s. 350-9, 2006.

Prediction of ADMET Properties.

Norinder, U; Bergström, C

Ingår i ChemMedChem, s. 920-937, 2006.

Prediction of ADMET Properties

Norinder, Ulf; Bergström, Christel

Ingår i ChemMedChem, s. 920-937, 2006.

DOI för Prediction of ADMET Properties

Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

Sai, Yoshimichi; Kaneko, Yosuke; Ito, Satsuki; Mitsuoka, Keisuke et al.

Ingår i Drug Metab Dispos, s. 1423-31, 2006.

Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Englund, Gunilla; Rorsman, Fredrik; Rönnblom, Anders; Karlbom, Urban et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 269-277, 2006.

DOI för Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells

Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

Issa, Mohamed; Köping-Höggård, Magnus; Tammeraas, Kristoffer; Vårum, Kjell M. et al.

Ingår i Journal of Controlled Release, s. 103-112, 2006.

DOI för Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo

A miniaturized nebulization catheter for improved gene delivery to the mouse lung.

Köping-Höggård, Magnus; Issa, Mohamed M; Köhler, Tamara; Tronde, Ann et al.

Ingår i J Gene Med, s. 1215-22, 2005.

Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.

Avdeef, Alex; Artursson, Per; Neuhoff, Sibylle; Lazorova, Lucia et al.

Ingår i Eur J Pharm Sci, s. 333-49, 2005.

Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study

Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Ingår i Analytical Chemistry, s. 5488-5493, 2005.

Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Bergström, Christel

Ingår i Expert opinion on drug metabolism & toxicology, s. 613-627, 2005.

DOI för Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Exploring the role of different drug transport routes in permeability screening.

Matsson, Pär; Bergström, Christel A S; Nagahara, Naoki; Tavelin, Staffan et al.

Ingår i J Med Chem, s. 604-13, 2005.

Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.

Feith, G; Lindberg, S; Itoh, K; Okada, N et al.

Ingår i Int J Pharm, s. 127-, 2005.

Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.

Yasar, U; Annas, A; Svensson, J-O; Lazorova, L et al.

Ingår i Xenobiotica, s. 785-96, 2005.

Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.

Hubatsch, Ina; Lazorova, Lucia; Vahlne, Anders; Artursson, Per

Ingår i Antimicrob Agents Chemother, s. 1087-92, 2005.

Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.

des Rieux, Anne; Ragnarsson, Eva G E; Gullberg, Elisabet; Preat, Veronique et al.

Ingår i Eur J Pharm Sci, s. 455-65, 2005.

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Ingår i J Electr Spectr, s. 283-285, 2005.

Accuracy of calculated pH-dependent aqueous drug solubility.

Bergström, Christel A S; Luthman, Kristina; Artursson, Per

Ingår i Eur J Pharm Sci, s. 387-98, 2004.

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Englund, Gunilla; Hallberg, Pär; Artursson, Per; Michaëlsson, Karl et al.

Ingår i BMC Medicine, s. 8-, 2004.

DOI för Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.

Nagahara, Naoki; Tavelin, Staffan; Artursson, Per

Ingår i J Pharm Sci, s. 2972-84, 2004.

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker ofMDR1-dependent drug efflux activity.

Taipalensuu, J; Tavelin, S; Lazorova, L; Svensson, AC et al.

Ingår i Eur J Pharm Sci, s. 69-, 2004.

Global and local computational models for aqueous solubility prediction of drug-like molecules.

Bergström, Christel A S; Wassvik, Carola M; Norinder, Ulf; Luthman, Kristina et al.

Ingår i J Chem Inf Comput Sci, s. 1477-88, 2004.

Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.

Köping-Höggård, M; Vårum, K M; Issa, M; Danielsen, S et al.

Ingår i Gene Ther, s. 1441-52, 2004.

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Ingår i Clinical Pharmacokinetics, s. 877-899, 2002.