Publikationer 2015 och tidigare
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Addendum to 'Quantifying the impact of transporters on cellular drug permeability'
Ingår i TIPS - Trends in Pharmacological Sciences, s. 559-559, 2015.
DOI för Addendum to 'Quantifying the impact of transporters on cellular drug permeability'
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Breaking the intestinal barrier to deliver drugs
Ingår i Science, s. 716-717, 2015.
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Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure
Ingår i Journal of Proteome Research, s. 3305-3314, 2015.
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Computational modeling to predict the functions and impact of drug transporters
Ingår i In silico pharmacology, 2015.
DOI för Computational modeling to predict the functions and impact of drug transporters Ladda ner fulltext (pdf) av Computational modeling to predict the functions and impact of drug transporters
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Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
Ingår i Pharmaceutical research, s. 578-589, 2015.
DOI för Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid Ladda ner fulltext (pdf) av Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
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Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
Ingår i European Journal of Pharmaceutical Sciences, s. 12-20, 2015.
DOI för Concomitant intake of alcohol may increase the absorption of poorly soluble drugs Ladda ner fulltext (pdf) av Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
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Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance
Ingår i Drug metabolism reviews (Softcover ed.), s. 245-246, 2015.
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Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
Ingår i Current molecular biology reports, s. 141-147, 2015.
DOI för Models for Predicting Drug Absorption From Oral Lipid-Based Formulations Ladda ner fulltext (pdf) av Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
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Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability
Ingår i International Journal of Pharmaceutics, s. 312-317, 2015.
DOI för Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability Ladda ner fulltext (pdf) av Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability
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Quantifying the impact of transporters on cellular drug permeability.
Ingår i TIPS - Trends in Pharmacological Sciences, s. 255-262, 2015.
DOI för Quantifying the impact of transporters on cellular drug permeability. Ladda ner fulltext (pdf) av Quantifying the impact of transporters on cellular drug permeability.
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Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo
Ingår i European Journal of Medicinal Chemistry, s. 191-209, 2015.
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A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
Ingår i Journal of Medicinal Chemistry, s. 3005-3010, 2014.
DOI för A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
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Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket
Ingår i Journal of Medicinal Chemistry, s. 1790-1801, 2014.
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Computational predictions of glass-forming ability and crystallization tendency of drug molecules
Ingår i Molecular Pharmaceutics, s. 3123-3132, 2014.
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Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
Ingår i European Journal of Pharmaceutical Sciences, s. 173-199, 2014.
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Experimental and Computational Prediction of Glass Transition Temperature of Drugs
Ingår i JOURNAL OF CHEMICAL INFORMATION AND MODELING, s. 3396-3403, 2014.
DOI för Experimental and Computational Prediction of Glass Transition Temperature of Drugs
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Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues
Ingår i ACS Medicinal Chemistry Letters, s. 1272-1277, 2014.
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Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis
Ingår i PLOS ONE, s. e110918-, 2014.
DOI för Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis Ladda ner fulltext (pdf) av Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis
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Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions
Ingår i Drug Metabolism And Disposition, s. 1210-1218, 2014.
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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties
Ingår i Journal of Medicinal Chemistry, s. 2746-2754, 2014.
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Is the full potential of the biopharmaceutics classification system reached?
Ingår i European Journal of Pharmaceutical Sciences, s. 224-231, 2014.
DOI för Is the full potential of the biopharmaceutics classification system reached?
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Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
Ingår i ACS Medicinal Chemistry Letters, s. 249-254, 2014.
DOI för Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
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Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition
Ingår i Molecular Pharmaceutics, s. 1727-1738, 2014.
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Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei
Ingår i Journal of Medicinal Chemistry, s. 6393-6402, 2014.
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Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles
Ingår i Bioorganic & Medicinal Chemistry, s. 6595-6615, 2014.
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An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux
Ingår i Molecular Pharmaceutics, s. 3152-3163, 2013.
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Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
Ingår i Pharmaceutical research, s. 3225-3237, 2013.
DOI för Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Ladda ner fulltext (pdf) av Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
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Computational Prospecting for Drug-Transporter Interactions
Ingår i Clinical Pharmacology and Therapeutics, s. 30-32, 2013.
DOI för Computational Prospecting for Drug-Transporter Interactions
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Constrained H-Phe-Phe-NH2 Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability
Ingår i Journal of Medicinal Chemistry, s. 4953-4965, 2013.
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Early drug development predictions of glass-forming ability and physical stability of drugs
Ingår i European Journal of Pharmaceutical Sciences, s. 323-332, 2013.
DOI för Early drug development predictions of glass-forming ability and physical stability of drugs Ladda ner fulltext (pdf) av Early drug development predictions of glass-forming ability and physical stability of drugs
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Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
Ingår i Toxicological Sciences, s. 328-343, 2013.
DOI för Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) Ladda ner fulltext (pdf) av Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
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Early recognition of absorption challenges of contemporary targets:: key molecular properties and in silico tools
Ingår i Bulletin Technique Gattefossé, s. 50-57, 2013.
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Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis
Ingår i Molecular Pharmaceutics, s. 2823-2848, 2013.
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Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice
Ingår i Journal of Medicinal Chemistry, s. 2690-2694, 2013.
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Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat
Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 117-128, 2013.
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Rapid Measurement of Intracellular Unbound Drug Concentrations
Ingår i Molecular Pharmaceutics, s. 2467-2478, 2013.
DOI för Rapid Measurement of Intracellular Unbound Drug Concentrations
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The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox
Ingår i Toxicology in Vitro, s. 1357-1376, 2013.
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Caco-2 monolayers in experimental and theoretical predictions of drug transport
Ingår i Advanced Drug Delivery Reviews, s. 280-289, 2012.
DOI för Caco-2 monolayers in experimental and theoretical predictions of drug transport
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Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions
Ingår i Journal of Medicinal Chemistry, s. 4740-4763, 2012.
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Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset
Ingår i Pharmaceutical research, s. 3131-3142, 2012.
DOI för Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset
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Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid
Ingår i Molecular Pharmaceutics, s. 1942-1952, 2012.
DOI för Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid
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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
Ingår i Drug Discovery Today, s. 905-912, 2012.
DOI för Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
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Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions
Ingår i The Pharmacogenomics Journal, s. 400-411, 2011.
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Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors
Ingår i Journal of Pharmaceutical Sciences, s. 3763-3772, 2011.
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Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development
Ingår i Molecular Pharmaceutics, s. 498-506, 2011.
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A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery
Ingår i Molecular pharmaceutics, s. 1478-1487, 2010.
DOI för A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery
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Coexistence of passive and carrier-mediated processes in drug transport
Ingår i Nature reviews. Drug discovery, s. 597-614, 2010.
DOI för Coexistence of passive and carrier-mediated processes in drug transport
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Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media
Ingår i Molecular pharmaceutics, s. 1419-1430, 2010.
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In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation
Ingår i Bioorganic & Medicinal Chemistry, s. 5896-5902, 2010.
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Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte
Ingår i Drug metabolism reviews (Softcover ed.), s. 306-307, 2010.
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Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)
Ingår i Drug metabolism reviews (Softcover ed.), s. 304-305, 2010.
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Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking
Ingår i Biomaterials, s. 975-987, 2010.
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Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models
Ingår i Journal of Pharmaceutical Sciences, s. 2166-2175, 2010.
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Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)
Ingår i Drug metabolism reviews (Softcover ed.), s. 305-306, 2010.
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Uptake mechanism of ochratoxin A and citrinin through human liver
Ingår i Drug metabolism reviews (Softcover ed.), s. 315-315, 2010.
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Endogenous Gene and Protein Expression of Drug Transporting Proteins in Cell Lines Routinely used in Drug Discovery Programs
Ingår i Drug Metabolism And Disposition, s. 2275-2283, 2009.
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Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells
Ingår i European Journal of Pharmaceutical Sciences, s. 556-563, 2009.
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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs
Ingår i Pharmaceutical research, s. 1816-1831, 2009.
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Ingår i European Journal of Pharmaceutical Sciences, s. 383-396, 2008.
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Molecular characteristics for solid-state limited solubility
Ingår i Journal of Medicinal Chemistry, s. 3035-3039, 2008.
DOI för Molecular characteristics for solid-state limited solubility
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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)
Ingår i Journal of Medicinal Chemistry, s. 3275-3287, 2008.
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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
Ingår i Journal of Medicinal Chemistry, s. 5932-5942, 2008.
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Tailoring of chitosans for gene delivery: novel self-branched glycosylated chitosan oligomers with improved functional properties
Ingår i Biomacromolecules, s. 3268-76, 2008.
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Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis
Ingår i Laboratory investigation; a journal of technical methods and pathology, s. 1215-26, 2008.
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A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)
Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 19-30, 2007.
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Advantages and disadvantages of using bovine serum albumin and/or Cremophor EL as extracellular additives during transport studies of lipophilic compounds across Caco-2 monolayers
Ingår i Journal of drug delivery science and technology, s. 259-266, 2007.
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Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1
Ingår i Journal of Medicinal Chemistry, s. 5238-5242, 2007.
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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
Ingår i Nature Protocols, s. 2111-2119, 2007.
DOI för Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
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Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1)
Ingår i Inflammatory Bowel Diseases, s. 291-297, 2007.
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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
Ingår i Drug Metabolism And Disposition, s. 1333-1340, 2007.
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Photoinduced Formation of N2 Molecules in Ammonium Compounds
Ingår i Journal of Physical Chemistry A, s. 9662-9669, 2007.
DOI för Photoinduced Formation of N2 Molecules in Ammonium Compounds
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Poorly soluble marketed drugs display solvation limited solubility
Ingår i Journal of Medicinal Chemistry, s. 5858-5862, 2007.
DOI för Poorly soluble marketed drugs display solvation limited solubility
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Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.
Ingår i Lab Invest, s. 504-16, 2006.
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Contribution of solid-state properties to the aqueous solubility of drugs.
Ingår i Eur J Pharm Sci, s. 294-305, 2006.
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Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery
Ingår i Pharmaceutical research, s. 475-482, 2006.
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Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer's Patches
Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 632-639, 2006.
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Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.
Ingår i Pharm Res, s. 350-9, 2006.
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Prediction of ADMET Properties.
Ingår i ChemMedChem, s. 920-937, 2006.
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Prediction of ADMET Properties
Ingår i ChemMedChem, s. 920-937, 2006.
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Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.
Ingår i Drug Metab Dispos, s. 1423-31, 2006.
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Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison with Caco-2 cells
Ingår i European Journal of Pharmaceutical Sciences, s. 269-277, 2006.
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Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo
Ingår i Journal of Controlled Release, s. 103-112, 2006.
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A miniaturized nebulization catheter for improved gene delivery to the mouse lung.
Ingår i J Gene Med, s. 1215-22, 2005.
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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method.
Ingår i Eur J Pharm Sci, s. 333-49, 2005.
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Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study
Ingår i Analytical Chemistry, s. 5488-5493, 2005.
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Computational models to predict aqueous drug solubility, permeability and intestinal absorption
Ingår i Expert opinion on drug metabolism & toxicology, s. 613-627, 2005.
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Exploring the role of different drug transport routes in permeability screening.
Ingår i J Med Chem, s. 604-13, 2005.
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Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan microspheres.
Ingår i Int J Pharm, s. 127-, 2005.
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Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Ingår i Xenobiotica, s. 785-96, 2005.
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Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium.
Ingår i Antimicrob Agents Chemother, s. 1087-92, 2005.
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Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium.
Ingår i Eur J Pharm Sci, s. 455-65, 2005.
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X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.
Ingår i J Electr Spectr, s. 283-285, 2005.
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Accuracy of calculated pH-dependent aqueous drug solubility.
Ingår i Eur J Pharm Sci, s. 387-98, 2004.
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Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs.
Ingår i J Pharm Sci, s. 2972-84, 2004.
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Global and local computational models for aqueous solubility prediction of drug-like molecules.
Ingår i J Chem Inf Comput Sci, s. 1477-88, 2004.
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Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers.
Ingår i Gene Ther, s. 1441-52, 2004.
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Theoretical predictions of drug absorption in drug discovery and development
Ingår i Clinical Pharmacokinetics, s. 877-899, 2002.