ARTURSSON GROUP

We aim to understand drug delivery and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.

We take a multidisciplinary approach to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. For this purpose, we combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery.

Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery. It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform). UDOPP supports academic and industrial discovery projects with absorption, distribution, metabolism and elimination (ADME) as well as profiling of compound libraries, hits and leads. UDOPP also performs pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.