Senaste publikationer
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
Ingår i Alzheimer's Research & Therapy, 2023.
DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
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A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
Ingår i Journal of Neurochemistry, s. 413-425, 2023.
DOI för A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses Ladda ner fulltext (pdf) av A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
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Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates
Ingår i mAbs, 2023.
DOI för Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates Ladda ner fulltext (pdf) av Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates
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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
Ingår i Pharmaceutics, 2022.
DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody Ladda ner fulltext (pdf) av Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
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A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
Ingår i NEUROTHERAPEUTICS, s. 1588-1602, 2022.
DOI för A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice Ladda ner fulltext (pdf) av A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
Ingår i Alzheimer's Research & Therapy, 2022.
DOI för Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease Ladda ner fulltext (pdf) av Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
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Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
Ingår i Scientific Reports, 2022.
DOI för Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 Ladda ner fulltext (pdf) av Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells
Ingår i New Biotechnology, s. 9-19, 2021.
DOI för Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells Ladda ner fulltext (pdf) av Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells
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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
Ingår i Translational Neurodegeneration, 2021.
DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta Ladda ner fulltext (pdf) av Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
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Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
Ingår i Theranostics, s. 789-804, 2021.
DOI för Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain Ladda ner fulltext (pdf) av Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
Ingår i ACS Chemical Neuroscience, s. 2529-2541, 2021.
DOI för Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide Ladda ner fulltext (pdf) av Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
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Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
Ingår i Molecular Imaging and Biology, s. 665-675, 2021.
DOI för Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease Ladda ner fulltext (pdf) av Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
Ingår i The FASEB Journal, s. 13272-13283, 2020.
DOI för Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle. Ladda ner fulltext (pdf) av Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
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[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta
Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. S643-S643, 2018.
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Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
Ingår i Alzheimer's Research & Therapy, 2018.
DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
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Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018.
DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition Ladda ner fulltext (pdf) av Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
Ingår i Neuropharmacology, s. 1-9, 2018.
DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy Ladda ner fulltext (pdf) av Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
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Antibody-based PET radioligands for imaging of amyloid-beta protofibrils
Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 84-84, 2017.
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Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
Ingår i Theranostics, s. 308-318, 2017.
DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor Ladda ner fulltext (pdf) av Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
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A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
Ingår i NeuroImage, s. 55-63, 2017.
DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging Ladda ner fulltext (pdf) av A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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Evolution of the p53-MDM2 pathway
Ingår i BMC Evolutionary Biology, 2017.
DOI för Evolution of the p53-MDM2 pathway Ladda ner fulltext (pdf) av Evolution of the p53-MDM2 pathway
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Emergence and evolution of an interaction between intrinsically disordered proteins
Ingår i eLIFE, 2017.
DOI för Emergence and evolution of an interaction between intrinsically disordered proteins Ladda ner fulltext (pdf) av Emergence and evolution of an interaction between intrinsically disordered proteins
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Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody
Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017.
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A small bispecific antibody-based construct based on bapineuzumab as a PET tracer for amyloid beta pathology in brain
Ingår i Meeting abstract, 2017.
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
Ingår i Biological Procedures Online, 2017.
DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells Ladda ner fulltext (pdf) av Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
Ingår i PLOS ONE, s. e95619-, 2014.
DOI för The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain Ladda ner fulltext (pdf) av The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
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Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
Ingår i Nature Communications, s. 3215-, 2014.
DOI för Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations Ladda ner fulltext (pdf) av Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
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Hultqvist, Greta
Protein Folding, Binding and Evolution: PDZ domains and paralemmins as model systems
2013.
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Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations
Ingår i Journal of the American Chemical Society, s. 12998-13007, 2013.
DOI för Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations Ladda ner fulltext (pdf) av Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations
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An expanded view of the protein folding landscape of PDZ domains
Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 550-553, 2012.
DOI för An expanded view of the protein folding landscape of PDZ domains Ladda ner fulltext (pdf) av An expanded view of the protein folding landscape of PDZ domains
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Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains
Ingår i Journal of the American Chemical Society, s. 599-605, 2012.
DOI för Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains Ladda ner fulltext (pdf) av Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains
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Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
Ingår i PLOS ONE, s. e41850-, 2012.
DOI för Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions Ladda ner fulltext (pdf) av Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions
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Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. E392-E401, 2011.
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A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
Ingår i Journal of Neuroscience, s. 12584-12596, 2009.