Senaste publikationer

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023.

DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Morrison, Jamie I.; Metzendorf, Nicole G.; Rofo, Fadi; Petrovic, Alex et al.

Ingår i Journal of Neurochemistry, s. 413-425, 2023.

DOI för A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses Ladda ner fulltext (pdf) av A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

Petersen, Inga; Ali, Muhammad Ilyas; Petrovic, Alex; Ytterberg, Anders Jimmy et al.

Ingår i mAbs, 2023.

DOI för Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates Ladda ner fulltext (pdf) av Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022.

DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody Ladda ner fulltext (pdf) av Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Ingår i NEUROTHERAPEUTICS, s. 1588-1602, 2022.

DOI för A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice Ladda ner fulltext (pdf) av A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Ingår i Alzheimer's Research & Therapy, 2022.

DOI för Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease Ladda ner fulltext (pdf) av Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Ingår i Neuropharmacology, 2022.

DOI för In vivo imaging of alpha-synuclein with antibody-based PET Ladda ner fulltext (pdf) av In vivo imaging of alpha-synuclein with antibody-based PET

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Ingår i Scientific Reports, 2022.

DOI för Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 Ladda ner fulltext (pdf) av Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells

Napoleone, Antonino; Laurén, Ida; Linkgreim, Triinu; Dahllund, Leif et al.

Ingår i New Biotechnology, s. 9-19, 2021.

DOI för Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells Ladda ner fulltext (pdf) av Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Ingår i Translational Neurodegeneration, 2021.

DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta Ladda ner fulltext (pdf) av Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Ingår i Theranostics, s. 789-804, 2021.

DOI för Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain Ladda ner fulltext (pdf) av Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Ingår i ACS Chemical Neuroscience, s. 2529-2541, 2021.

DOI för Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide Ladda ner fulltext (pdf) av Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Meier, Silvio R.; Sehlin, Dag; Hultqvist, Greta; Syvänen, Stina

Ingår i Molecular Imaging and Biology, s. 665-675, 2021.

DOI för Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease Ladda ner fulltext (pdf) av Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta et al.

Ingår i The FASEB Journal, s. 13272-13283, 2020.

DOI för Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle. Ladda ner fulltext (pdf) av Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

Ingår i NeuroImage, s. 881-888, 2019.

DOI för High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta

Eriksson, Jonas; Fang, Xiaotian T.; Hultqvist, Greta; Olberg, D. E. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. S643-S643, 2018.

Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018.

DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018.

DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition Ladda ner fulltext (pdf) av Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Ingår i Neuropharmacology, s. 1-9, 2018.

DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy Ladda ner fulltext (pdf) av Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

Jemth, Per; Karlsson, Elin; Vogeli, Beat; Guzovsky, Brenda et al.

Ingår i Science Advances, 2018.

DOI för Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

Antibody-based PET radioligands for imaging of amyloid-beta protofibrils

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Falting, J. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 84-84, 2017.

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017.

DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor Ladda ner fulltext (pdf) av Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Ingår i NeuroImage, s. 55-63, 2017.

DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging Ladda ner fulltext (pdf) av A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Evolution of the p53-MDM2 pathway

Åberg, Emma; Saccoccia, Fulvio; Grabherr, Manfred; Ore, Wai Ying Josefin et al.

Ingår i BMC Evolutionary Biology, 2017.

DOI för Evolution of the p53-MDM2 pathway Ladda ner fulltext (pdf) av Evolution of the p53-MDM2 pathway

Emergence and evolution of an interaction between intrinsically disordered proteins

Hultqvist, Greta; Åberg, Emma; Camilloni, Carlo; Sundell, Gustav et al.

Ingår i eLIFE, 2017.

DOI för Emergence and evolution of an interaction between intrinsically disordered proteins Ladda ner fulltext (pdf) av Emergence and evolution of an interaction between intrinsically disordered proteins

Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017.

A small bispecific antibody-based construct based on bapineuzumab as a PET tracer for amyloid beta pathology in brain

Fang, Xiaotian; Hultqvist, Greta; Meier, Silvio; Sehlin, Dag et al.

Ingår i Meeting abstract, 2017.

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Ingår i Biological Procedures Online, 2017.

DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells Ladda ner fulltext (pdf) av Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain

Pedersen, Soren W.; Hultqvist, Greta; Stromgaard, Kristian; Jemth, Per

Ingår i PLOS ONE, s. e95619-, 2014.

DOI för The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain Ladda ner fulltext (pdf) av The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

Pedersen, Soren W.; Pedersen, Stine B.; Anker, Louise; Hultqvist, Greta et al.

Ingår i Nature Communications, s. 3215-, 2014.

DOI för Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations Ladda ner fulltext (pdf) av Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

Hultqvist, Greta

Protein Folding, Binding and Evolution: PDZ domains and paralemmins as model systems

2013.

Ladda ner fulltext (pdf) av Hultqvist, Greta

Energetic pathway sampling in a protein interaction domain

Hultqvist, Greta; Haq, Raza; Punekar, Avinash; Chi, Celestine et al.

Ingår i Structure, s. 1193-1202, 2013.

DOI för Energetic pathway sampling in a protein interaction domain Ladda ner fulltext (pdf) av Energetic pathway sampling in a protein interaction domain

Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations

Eildal, Jonas N. N.; Hultqvist, Greta; Balle, Thomas; Stuhr-Hansen, Nicolai et al.

Ingår i Journal of the American Chemical Society, s. 12998-13007, 2013.

DOI för Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations Ladda ner fulltext (pdf) av Probing the Role of Backbone Hydrogen Bonds in Protein-Peptide Interactions by Amide-to-Ester Mutations

An expanded view of the protein folding landscape of PDZ domains

Hultqvist, Greta; Pedersen, Søren; Strømgaard, Kristian; Chi, Celestine et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 550-553, 2012.

DOI för An expanded view of the protein folding landscape of PDZ domains Ladda ner fulltext (pdf) av An expanded view of the protein folding landscape of PDZ domains

Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains

Haq, S. Raza; Chi, Celestine N.; Bach, Anders; Dogan, Jakob et al.

Ingår i Journal of the American Chemical Society, s. 599-605, 2012.

DOI för Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains Ladda ner fulltext (pdf) av Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains

Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Hultqvist, Greta; Punekar, Avinash; Morrone, Angela; Chi, Celestine et al.

Ingår i PLOS ONE, s. e50055-, 2012.

DOI för Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain Ladda ner fulltext (pdf) av Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions

Hultqvist, Greta; Ocampo Daza, Daniel; Larhammar, Dan; Kilimann, Manfred W.

Ingår i PLOS ONE, s. e41850-, 2012.

DOI för Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions Ladda ner fulltext (pdf) av Evolution of the Vertebrate Paralemmin Gene Family: Ancient Origin of Gene Duplicates Suggests Distinct Functions

Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site

Limbach, Christoph; Laue, Michael M.; Wang, Xiaolu; Hu, Bin et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. E392-E401, 2011.

DOI för Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

Wang, Xiaolu; Hu, Bin; Zieba, Agata; Neumann, Nicole G et al.

Ingår i Journal of Neuroscience, s. 12584-12596, 2009.

DOI för A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1