Alla publikationer

Jamie I. Morrison, Alex Petrovic, Nicole G. Metzendorf, Fadi Rofo, Canan U. Yilmaz, Sofia Stenler, Hanna Laudon, and Greta Hultqvist. Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways. Published 2023-02-21 in Molecular Pharmaceutics.

Morrison, J.*, Metzendorf, N.* G., Rofo, F., Petrovic, A., and Hultqvist, G.* A single chain fragment constant (scFc) design enables easy production of a monovalent BBB transporter and provides an improved brain uptake at elevated doses. Accepted 2023-01-17 in Journal of Neurochemistry.

De la Rosa, A., Metzendorf, N., Morrison, J., Faresjö, R.  Rofo, F., Petrovic, A., and O´Callgahan, P., Syvänen, S. and Hultqvist, G*. Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3. Accepted 2022-12-04. Scientific reports 

Rofo, F. #, Metzendorf, N. #, Saubi, C, .Suominen, L., Godec, A., Sehlin, D., Syvänen, S., Hultqvist, G.* Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease. Accepted 2022-11-25 in Alzheimer’s research and therapy.

Rofo.F, Meier, S., Metzendorf, N., Morrison, J., Petrovic, A., Syvänen, S., Sehlin, D., Hultqvist, G.*.  A brain-targeting bispecific-multivalent antibody clears soluble amyloid-beta aggregates in Alzheimer’s disease mice. Neurotherapeutics. 2022 

Roshanbin S, Xiong M, Hultqvist G, Söderberg L, Zachrisson O, Meier S, Ekmark-Lewén S, Bergström J, Ingelsson M, Sehlin D, Syvänen S. In vivo imaging of alpha-synuclein with antibody-based PET. Neuropharmacology. Published 2021

Rofo,F., Buijs, J., Falk, R., Honek, K., Lannfelt, L., Lilja, A. M., Metzendorf, N., Gustavsson, T., Sehlin, D., Söderberg, L. and Hultqvist, G.* Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta. Translational neurodegeneration. Published September 2021

Napoleone, A., Laurén, I., Linkgreim, T., Dahllund, L., Persson,   Fig. 1                       H., Andersson, O., Olsson, A., Hultqvist, G., Frank, P.,Hall, M., Morrisson, A., Andersson, A., Lord, M. and Mangsbo, S. Fed-batch production assessment of a tetravalent bispecific antibody: a case study on piggyBac stably transfected HEK293 cells. Journal of new biotechnology. 2021

Rofo, F ; Sandbaumhuter, F.; Chourlia, A.; Metzendorf, N., Morrison,                                  J.; Syväenen, S., Andren, P.; Jansson, E. and HultqvistG.*. Wide-ranging effects on the brain proteome in a transgenic mouse model of Alzheimer’s disease following treatment with a brain-targeting somatostatin peptide. ACS Chemical Neuroscience. Accepted in June 2021

Meier, S., Sehlin, D., Hultqvist, G. and Syvänen, S.,                                              Pinpointing brain TREM2 levels in two mouse models of Alzheimers disease. Molecular imaging and biology (2021)

Rofo,F.,  Ugur Yilmaz1,  C., MetzendorfN., Gustavsson, T., Beretta,Graphic abstract                                         C., Erlandsson, A.,  Sehlin, D., Syvänen, S.,  Nilsson, P.,  and Hultqvist, G.* Enhanced neprilysin-mediated degradation of hippocampal Ab42 with a somatostatin peptide that enters the brain. 2020. Theranostics

Sehlin D, Stocki P, Gustavsson T, Hultqvist G, Walsh FS, Rutkoimagewski JL, Syvänen S. Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle. (2020) FASEB J. 

20.   Fang, X.T., Hultqvist, G., Meier, S. R., Antoni, G., Sehlin, D. and Syvänen, S. High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain. (2018). NeuroImage

19. Jemth, P., Karlsson, E., Vögeli, B., Guzovsky, B., Andersson, E., Hultqvist, G., Dogan, J., Güntert, P., Riek, R., and Celestine N Chi. Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins. (2018).  Science Advances.

18. Gustafsson, S., Gustavsson, T., Roshanbin, S., Hultqvist, G.,Hammarlund-Udenaes, M., Sehlin, D., and Syvänen, S. Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer's Disease With or Without Acute 3D6 Immunotherapy. (2018). Neuropharmacology

17.  Syvänen, S., Hultqvist, G., Gustavsson, T., Gumucio, A., Laudon, H., Söderberg, L., Ingelsson, M., Lannfelt, L. and Sehlin, D. Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain penetrating bifunctional antibody. (2018). Alzheimer's Research & Therapy

16. Meier, S. R., Syvänen, S., Hultqvist, G., Fang, X. T., Roshanbin, S., Lannfelt, L., Neumann, U. and Sehlin, D. Antibody-based in vivo PET imaging detects amyloid-β reduction in Alzheimer transgenic mice after BACE-1 inhibition. (2018). Journal of Nuclear Medicine.

15.  Fang, X.T., Sehlin, D., Lannfelt, L., Syvänen, S. and Hultqvist, G*. Efficient and inexpensive transient expression of multispecific multivalent antibodies in expi293 cells. (2017). Biological Procedures Online. 19. 1480-9222

14. Åberg, E., Saccoccia, F., Grabherr, M., Ore, W.Y.J., Jemth, P. and Hultqvist, G*. Evolution of the p53-MDM2 pathway. (2017). BMC Evol Biol 3;17(1):177

13. Hultqvist, G.*, Åberg, E., Camilloni, C., Celestine, C., Sundell, G., Andersson, E., Dogan, J., Vendruscolo, M. and Jemth, P.*. Emergence and evolution of a protein-protein interaction between intrinsically disordered domains. (2017).eLife.;6:e16059  

12. Hultqvist, G.*, Syvänen, S., Fang, X.T., Lannfelt, L., and                                       Sehlin, D.   Bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor. (2017). Theranostics

11.  Syvänen, S., Fang, X.T., Hultqvist, G., Meier, S.R., Lannfelt. L., and Sehlin, D. A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils-a new concept for neuroimaging. (2017).  NeuroImage

10.  Pedersen, S. W., Hultqvist, G., Strømgaard, K. & Jemth, P. The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain. (2014). PLoS ONE 9, e95619

9.    Pedersen, S.W., Pedersen, S.B., Anker, L., Hultqvist, G., Kristensen, A.S., Jemth, P., and Strømgaard, K. Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations. (2014).  Nat Commun 5.

8.    Hultqvist, G., Haq, S.R., Punekar, A.S., Chi, C.N., Engström, Å., Bach, A., Strømgaard, K., Selmer, M., Gianni, S., and Jemth, P. Energetic pathway sampling in a protein interaction domain. (2013).  Structure 21, 1193–1202.

7.    Eildal, J.N.N., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, K., and Jemth, P. Probing the role of backbone hydrogen bonds in protein–peptide interactions by amide-to-ester mutations. (2013). J. Am. Chem. Soc. 135, 12998–13007.

6.    Hultqvist, G., Punekar, A.S., Morrone, A., Chi, C.N., Engström,                                       Å., Selmer, M., Gianni, S., and Jemth, P. Tolerance of protein folding to a circular permutation in a PDZ domain. (2012). PLoS ONE 7, e50055.

5.    Hultqvist, G., Pedersen, S.W., Chi, C.N., Strømgaard, K., Gianni, S., and Jemth, P. An expanded view of the protein folding landscape of PDZ domains. (2012). Biochem. Biophys. Res. Commun. 421, 550–553.

4.    Haq, S.R., Chi, C.N., Bach, A., Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O.A., Lundström, P., Montemiglio, L.C., Strømgaard, K., et al. Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. (2012). J Am Chem Soc 134, 599–605.

3.    Hultqvist, G.*, Ocampo Daza, D., Larhammar, D., and Kilimann, M.W. Evolution of the vertebrate Paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. (2012). PLoS ONE 7, e41850.

2.    Limbach, C., Laue, M.M., Wang, X., Hu, B., Thiede, N., Hultqvist, G., and Kilimann, M.W. Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site. (2011). Proc. Natl. Acad. Sci. 108, E392–E401.

1.    Wang, X., Hu, B., Zieba, A., Neumann, N.G., Kasper-Sonnenberg, M., Honsbein, A., Hultqvist, G., Conze, T., Witt, W., Limbach, C., et al. A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1. (2009). J. Neurosci. Off. J. Soc. Neurosci. 29, 12584–12596.

Senast uppdaterad: 2023-03-09