Department of Pharmacy
We teach, research and collaborate with society on issues related to the development, manufacture and the use of drugs. Pharmacy is a broad area with boundaries to natural, social and engineering sciences.
SweDeliver
New competence center
Academia and industry shaping the future of drug delivery
UDOPP
Research platform
Uppsala University Drug Optimization and Pharmaceutical Profiling platform
Alumn
Alumni association
News
- 16.68 million to research at the pharmaceutical faculty. 2020-11-16
- Professor Per Artursson: Giant of Pharmaceutical Sciences 2020-11-11
- PhD-student position for project regarding the impact of drug exposure in the human colon 2020-11-11
- PhD-student position for project regarding importance of diffusion, dissolution and release mechanisms for dosage forms delivering drugs to the colonic environment 2020-11-02
- Maria Karlgren receives the 2020 IQ Consortium and AAALAC International Global 3Rs Award 2020-10-30
Calendar
Publications
-
Schmidt-Mende, Katharina; Andersen, Morten; Wettermark, Björn; Hasselstrom, Jan
Drug-disease interactions in Swedish senior primary care patients were dominated by non-steroid anti-inflammatory drugs and hypertension - a population-based registry study
2020
-
Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran; Soderhall, Arvid; Hellström, Per M.; Lennernäs, Hans
Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
2020
-
Ravandeh, M.; Kahlert, H.; Jablonowski, H.; Lackmann, J. -W; Striesow, J.; Agmo Hernández, Víctor; Wende, K.
A combination of electrochemistry and mass spectrometry to monitor the interaction of reactive species with supported lipid bilayers
2020
-
Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik
Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling
2020
-
Hansson, Per
Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins
2020
-
Ekheden, Isabella; Ebrahim, Fereshte; olafsdottir, Halla; Raaschou, Pauline; Wettermark, Björn; Henriksson, Roger; Ye, Weimin
Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort
2020
-
Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria
Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
2020
-
Bergström, Christel; Llinas, Antonio
Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds
2020
-
Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per
Cell-type-resolved proteomic analysis of the human liver
2020
-
Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik
Investigating drug permeation across a lipid membrane supported on mesoporous silica.
2020
-
Sou, Tomás; Bergström, Christel A S
Contemporary formulation development for inhaled pharmaceuticals.
2020
-
Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver; Höök, Fredrik; Larsson, Per; Bergström, Christel A S
Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers.
2020
-
Wright, Leah; Joyce, Paul; Barnes, Timothy J; Lundmark, Richard; Bergström, Christel A S; Hubert, Madlen; Prestidge, Clive A
A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics.
2020
-
El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.
Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs
2020
-
Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.
Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization
2020
-
An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael; Frenning, Göran
Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles
2020
-
Teleki, Alexandra; Nylander, Olivia; Bergström, Christel
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
2020
-
Norinder, Ulf; Spjuth, Ola; Svensson, Fredrik
Using Predicted Bioactivity Profiles to Improve Predictive Modeling
2020
-
Sinko, Patrick D.; Harris, Sarah; Salehi, Niloufar; Meyer, Pamela J.; Amidon, Gordon L.; Amidon, Gregory E.
Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies
2020
-
Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik
MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.
2020
-
Dahlgren, David; Lennernäs, Hans
Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
2020
-
Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P.; Butler, J.; Holm, R.; Langguth, P.; Lindahl, A.; Muellertz, A.; Pepin, X.; Rostami-Hodjegan, A.; Sjögren, Erik; Berntsson, M.; Lennernäs, Hans
Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project
2020
-
Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran
Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling
2020
-
Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Haggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
2020
-
Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina; Brown, Christopher J.; Lane, David P.; Edwards, Katarina; Nestor, Marika
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
2020
-
Van Wijk, Rob C; van der Sar, Astrid M; Krekels, Elke H J; Verboom, Theo; Spaink, Herman P; Simonsson, Ulrika S H; Van der Graaf, Piet H
Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translationa lAntituberculosis Drug Development
2020
-
Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H
Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
2020
-
Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert
CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A
2020
-
Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N.; Richardson, William; Lucanto, Simone; Oton, Eduard Vico; Qudus, Naim Ruhul; Mashabi, Alaa; Grossman, Scott; Ali, Sadiqur; Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Halliday, Nigel; Mistry, Shailesh N.; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Camara, Miguel; Stocks, Michael J.
Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa
2020
-
Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
2020
-
Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean; Strömme, Maria; Gogoll, A; Prestidge, Clive A; Bergström, Christel A. S.
In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
2020
-
Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena
Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
2020
-
Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena; Bergström, Christel
Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections
2020
-
Nakai, Daisuke; Miyake, Masateru; Hashimoto, Ayako
Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis
2020
-
Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael; Sjöblom, Markus; Lennernäs, Hans
Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
2020
-
Borro, Bruno C.; Nordström, Randi; Malmsten, Martin
Microgels and hydrogels as delivery systems for antimicrobial peptides
2020
-
Al-Tikriti, Yassir; Hansson, Per
Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline
2020
-
Hedge, Oliver; Bergström, Christel A. S.
Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations
2020
-
Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean; Strömme, Maria; Bergström, Christel
An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
2020
-
Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans
The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
2020
-
Hubert, Madlen; Larsson, Elin; Lundmark, Richard
Keeping in touch with the membrane: protein- and lipid-mediated confinement of caveolae to the cell surface
2020
-
Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E.; Bergström, Christel
Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties
2020
-
Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian; He, Handan; Ju, Rob; Kanodia, Jitendra; Lennernäs, Hans; Lindley, David; Polli, James E.; Wenning, Larissa; Wu, Yunhui
ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium
2020
-
Artursson, Per; Lundquist, Patrik
A new opening for orally taken peptide drugs
2020
-
Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo; Hjelmesaeth, Jöran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity
2020
-
Kishani, Saina; Vilaplana, Francisco; Ruda, Marcus; Hansson, Per; Wågberg, Lars
Influence of Solubility on the Adsorption of Different Xyloglucan Fractions at Cellulose–Water Interfaces
2020
-
Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per
Global variability analysis of mRNA and protein concentrations across and within human tissues
2020
-
Nordström, Randi; Browning, Kathryn L.; Parra-Ortiz, Elisa; Dangaard, Liv Sofia Elinor; Malekkhaiat-Häffner, Sara; Maestro, Armando; Campbell, Richard A.; Cooper, Joshaniel F. K.; Malmsten, Martin
Membrane Interactions of Antimicrobial Peptide-Loaded Microgels
2020
-
Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; O'Brien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
2020
-
Pazesh, Samaneh; Persson, Ann-Sofie; Alderborn, Göran
Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern
2019
-
Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michael; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato
Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
2019
-
Lenhart, Vincent; Quodbach, Julian; Kleinebudde, Peter
Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films
2019
-
Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim; Lindgren, Anders E. G.; Wede, Emma; Singh, Pardeep; Vielfort, Katarina; Bahnan, Wael; Good, James A. D.; Svensson, Richard; Bergström, Sven; Gylfe, Åsa; Almqvist, Fredrik
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
2019
-
Malekkhaiat Häffner, Sara; Nyström, Lina; Strömstedt, Adam A.; Li, Li; van der Plas, Mariena J A; Malmsten, Martin
Nanoclay-induced bacterial flocculation for infection confinement
2019
-
Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär; Artursson, Per
A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
2019
-
Sjögren, Erik; Stahle, Lars; Quiding, Hans; Jonzon, Bror; Halldin, Magnus M.; Sundgren, Anna K.
The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers
2019
-
Ilyas, Humaira; Kim, JaeWoong; Lee, DongKuk; Malmsten, Martin; Bhunia, Anirban
Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism
2019
-
Norling, Karin; Bernasconi, Valentina; Agmo Hernandez, Victor; Parveen, Nagma; Edwards, Katarina; Lycke, Nils Y; Höök, Fredrik; Bally, Marta
Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major Histocompatibility Complex Class II and Costimulatory Molecule Display by Dendritic Cells in Vitro
2019
-
Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans
Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations
2019
-
Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans
Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions
2019
-
Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A.; Tannergren, C.; Sjögren, Erik; Sjöblom, Markus; Lennernäs, Hans
Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model
2019
-
Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans
Rat intestinal drug permeability: A status report and summary of repeated determinations
2019
-
Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik; Lennernäs, Hans
Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
2019
-
Reis, Pedro; Malmsten, Martin; Nydén, Magnus; Folmer, Britta; Holmberg, Krister
Interactions between Lipases and Amphiphiles at Interfaces
2019
-
Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik; Hansson, Per; Lennernäs, Hans
Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
2019
-
Dahlgren, David; Lennernäs, Hans
Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
2019
-
Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A.; Lai, Yurong; Smith, Philip C.; Barber, Jill; Wisniewski, Jacek R.; Spellman, Daniel; Uchida, Yasuo; Zientek, Michael A.; Unadkat, Jashvant D.; Rostami-Hodjegan, Amin
Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper
2019
-
Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel; Nielsen, Carsten Uhd; Steffansen, Bente
The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach
2019
-
Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin; Brouwers, Joachim; Augustijns, Patrick; Brandl, Martin; Bernkop-Schnürch, Andreas; Shrestha, Neha; Preat, Veronique; Müllertz, Anette; Bauer-Brandl, Annette; Jannin, Vincent
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
2019
-
Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.
Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?
2019